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Protein

Mitochondrial-processing peptidase subunit beta

Gene

Pmpcb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cleaves presequences (transit peptides) from mitochondrial protein precursors.By similarity

Catalytic activityi

Release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi101ZincPROSITE-ProRule annotation1
Active sitei104Proton acceptorPROSITE-ProRule annotation1
Metal bindingi105ZincPROSITE-ProRule annotation1
Metal bindingi181ZincPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-8949664 Processing of SMDT1

Protein family/group databases

MEROPSiM16.003

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial-processing peptidase subunit beta (EC:3.4.24.64)
Alternative name(s):
Beta-MPP
P-52
Gene namesi
Name:Pmpcb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1920328 Pmpcb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 45MitochondrionBy similarityAdd BLAST45
ChainiPRO_000002677846 – 489Mitochondrial-processing peptidase subunit betaAdd BLAST444

Proteomic databases

EPDiQ9CXT8
MaxQBiQ9CXT8
PaxDbiQ9CXT8
PRIDEiQ9CXT8

2D gel databases

REPRODUCTION-2DPAGEiQ9CXT8

PTM databases

iPTMnetiQ9CXT8
PhosphoSitePlusiQ9CXT8
SwissPalmiQ9CXT8

Expressioni

Gene expression databases

BgeeiENSMUSG00000029017
CleanExiMM_PMPCB
ExpressionAtlasiQ9CXT8 baseline and differential
GenevisibleiQ9CXT8 MM

Interactioni

Subunit structurei

Heterodimer of alpha and beta subunits.By similarity

Protein-protein interaction databases

IntActiQ9CXT8, 2 interactors
MINTiQ9CXT8
STRINGi10090.ENSMUSP00000030882

Structurei

3D structure databases

ProteinModelPortaliQ9CXT8
SMRiQ9CXT8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M16 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0960 Eukaryota
COG0612 LUCA
GeneTreeiENSGT00550000074701
HOGENOMiHOG000242450
HOVERGENiHBG006393
InParanoidiQ9CXT8
KOiK17732
OMAiNGSYRDM
OrthoDBiEOG091G05W9
PhylomeDBiQ9CXT8
TreeFamiTF105032

Family and domain databases

InterProiView protein in InterPro
IPR011249 Metalloenz_LuxS/M16
IPR037718 MPP_beat
IPR011765 Pept_M16_N
IPR001431 Pept_M16_Zn_BS
IPR007863 Peptidase_M16_C
PANTHERiPTHR11851:SF103 PTHR11851:SF103, 1 hit
PfamiView protein in Pfam
PF00675 Peptidase_M16, 1 hit
PF05193 Peptidase_M16_C, 1 hit
SUPFAMiSSF63411 SSF63411, 2 hits
PROSITEiView protein in PROSITE
PS00143 INSULINASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CXT8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAALSRTL LPEARRRLWG FTRRLPLRRA AAQPLYFGGD RLRSTQAAPQ
60 70 80 90 100
VVLNVPETQV TCLENGLRVA SENSGLSTCT VGLWIDAGSR YENEKNNGTA
110 120 130 140 150
HFLEHMAFKG TKKRSQLDLE LEIENMGAHL NAYTSREQTV YYAKAFSRDL
160 170 180 190 200
PRAVEILADI IQNSTLGEAE IERERGVILR EMQEVETNLQ EVVFDYLHAT
210 220 230 240 250
AYQNTALGRT ILGPTENIKS INRKDLVDYI TTHYKGPRIV LAAAGGVCHN
260 270 280 290 300
ELLELAKFHF GDSLCSHKGA IPALPPCKFT GSEIRVRDDK MPLAHLAIAV
310 320 330 340 350
EAVGWAHPDT ICLMVANTLI GNWDRSFGGG MNLSSKLAQL TCHGNLCHSF
360 370 380 390 400
QSFNTSYTDT GLWGLYMVCE QATVADMLHV VQNEWKRLCT DVTESEVARA
410 420 430 440 450
KNLLKTNMLL QLDGSTPICE DIGRQMLCYN RRIPIPELEA RIDAVDAETV
460 470 480
RRVCTKYIHD KSPAIAALGP IERLPDFNQI CSNMRWIRD
Length:489
Mass (Da):54,614
Last modified:June 1, 2001 - v1
Checksum:i1B594EE0B6FE34A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013995 mRNA Translation: BAB29105.1
CCDSiCCDS19106.1
RefSeqiNP_082707.1, NM_028431.2
UniGeneiMm.301655

Genome annotation databases

EnsembliENSMUST00000030882; ENSMUSP00000030882; ENSMUSG00000029017
GeneIDi73078
KEGGimmu:73078
UCSCiuc008wox.1 mouse

Similar proteinsi

Entry informationi

Entry nameiMPPB_MOUSE
AccessioniPrimary (citable) accession number: Q9CXT8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: June 1, 2001
Last modified: June 20, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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