UniProtKB - Q9CXT7 (TM192_MOUSE)
Protein
Transmembrane protein 192
Gene
Tmem192
Organism
Mus musculus (Mouse)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Transmembrane protein 192 |
Gene namesi | Name:Tmem192 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1920317, Tmem192 |
Subcellular locationi
Endosome
- Late endosome By similarity
Lysosome
- Lysosome membrane By similarity; Multi-pass membrane protein By similarity
Endosome
- endosome Source: MGI
- late endosome Source: MGI
Lysosome
- lysosomal membrane Source: MGI
- lysosome Source: MGI
Nucleus
- nucleoplasm Source: MGI
Other locations
- integral component of membrane Source: UniProtKB-KW
- perinuclear region of cytoplasm Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 46 | CytoplasmicSequence analysisAdd BLAST | 46 | |
Transmembranei | 47 – 67 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 68 – 89 | LumenalSequence analysisAdd BLAST | 22 | |
Transmembranei | 90 – 110 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 111 – 137 | CytoplasmicSequence analysisAdd BLAST | 27 | |
Transmembranei | 138 – 158 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 159 – 171 | LumenalSequence analysisAdd BLAST | 13 | |
Transmembranei | 172 – 192 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 193 – 266 | CytoplasmicSequence analysisAdd BLAST | 74 |
Keywords - Cellular componenti
Endosome, Lysosome, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000311268 | 1 – 266 | Transmembrane protein 192Add BLAST | 266 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 17 | PhosphoserineCombined sources | 1 | |
Modified residuei | 213 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 229 | PhosphoserineBy similarity | 1 | |
Modified residuei | 230 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q9CXT7 |
PeptideAtlasi | Q9CXT7 |
PRIDEi | Q9CXT7 |
PTM databases
iPTMneti | Q9CXT7 |
PhosphoSitePlusi | Q9CXT7 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000025521, Expressed in ear and 266 other tissues |
ExpressionAtlasi | Q9CXT7, baseline and differential |
Genevisiblei | Q9CXT7, MM |
Interactioni
Subunit structurei
Homodimer.
By similarityGO - Molecular functioni
- protein homodimerization activity Source: MGI
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000026595 |
Miscellaneous databases
RNActi | Q9CXT7, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the TMEM192 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QWR8, Eukaryota |
GeneTreei | ENSGT00390000013749 |
HOGENOMi | CLU_086771_0_0_1 |
InParanoidi | Q9CXT7 |
OMAi | TVIIIAK |
OrthoDBi | 1249559at2759 |
PhylomeDBi | Q9CXT7 |
TreeFami | TF323773 |
Family and domain databases
InterProi | View protein in InterPro IPR029399, TMEM192 |
PANTHERi | PTHR31592, PTHR31592, 1 hit |
Pfami | View protein in Pfam PF14802, TMEM192, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9CXT7-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAAGRLEDS SLDILQSMDD DPLLDTQPLP HHSLQAQFRP RFHPLPTVII
60 70 80 90 100
ANLLLLIHVV FVVLAFLTGV PCLYPNPTED KCPENYTSPL KVQTAIILGK
110 120 130 140 150
LILWILHLLF ERYVQYHHRK VRSRGYSQIY RSTRHLKTLA LTIHSSGNTA
160 170 180 190 200
LLLLLCVQHS FPEPSKLYLE LILAVLALEL ICSLSCLILY IVKIRRFNRA
210 220 230 240 250
KPLPDVLEEE KIYAYPSNTA SETGFRTVSS LEEIVEKQED IIVYLKRHNA
260
LLSKRLLELA TQPART
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1B0GS44 | A0A1B0GS44_MOUSE | Transmembrane protein 192 | Tmem192 | 258 | Annotation score: | ||
A0A1B0GRM5 | A0A1B0GRM5_MOUSE | Transmembrane protein 192 | Tmem192 | 108 | Annotation score: | ||
A0A1B0GT30 | A0A1B0GT30_MOUSE | Transmembrane protein 192 | Tmem192 | 68 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 111 | E → K in BAE40111 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_029503 | 147 – 191 | Missing in isoform 2. 1 PublicationAdd BLAST | 45 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK013998 mRNA Translation: BAB29107.1 AK046181 mRNA Translation: BAC32622.1 AK168146 mRNA Translation: BAE40111.1 BC020157 mRNA Translation: AAH20157.1 |
CCDSi | CCDS22329.1 [Q9CXT7-1] CCDS52559.1 [Q9CXT7-2] |
RefSeqi | NP_001157219.1, NM_001163747.1 [Q9CXT7-2] NP_082703.1, NM_028427.3 [Q9CXT7-1] |
Genome annotation databases
Ensembli | ENSMUST00000026595; ENSMUSP00000026595; ENSMUSG00000025521 [Q9CXT7-1] ENSMUST00000079896; ENSMUSP00000078819; ENSMUSG00000025521 [Q9CXT7-2] |
GeneIDi | 73067 |
KEGGi | mmu:73067 |
UCSCi | uc009lvb.3, mouse [Q9CXT7-1] uc009lvc.3, mouse [Q9CXT7-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK013998 mRNA Translation: BAB29107.1 AK046181 mRNA Translation: BAC32622.1 AK168146 mRNA Translation: BAE40111.1 BC020157 mRNA Translation: AAH20157.1 |
CCDSi | CCDS22329.1 [Q9CXT7-1] CCDS52559.1 [Q9CXT7-2] |
RefSeqi | NP_001157219.1, NM_001163747.1 [Q9CXT7-2] NP_082703.1, NM_028427.3 [Q9CXT7-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000026595 |
PTM databases
iPTMneti | Q9CXT7 |
PhosphoSitePlusi | Q9CXT7 |
Proteomic databases
PaxDbi | Q9CXT7 |
PeptideAtlasi | Q9CXT7 |
PRIDEi | Q9CXT7 |
Protocols and materials databases
Antibodypediai | 7685, 80 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000026595; ENSMUSP00000026595; ENSMUSG00000025521 [Q9CXT7-1] ENSMUST00000079896; ENSMUSP00000078819; ENSMUSG00000025521 [Q9CXT7-2] |
GeneIDi | 73067 |
KEGGi | mmu:73067 |
UCSCi | uc009lvb.3, mouse [Q9CXT7-1] uc009lvc.3, mouse [Q9CXT7-2] |
Organism-specific databases
CTDi | 201931 |
MGIi | MGI:1920317, Tmem192 |
Phylogenomic databases
eggNOGi | ENOG502QWR8, Eukaryota |
GeneTreei | ENSGT00390000013749 |
HOGENOMi | CLU_086771_0_0_1 |
InParanoidi | Q9CXT7 |
OMAi | TVIIIAK |
OrthoDBi | 1249559at2759 |
PhylomeDBi | Q9CXT7 |
TreeFami | TF323773 |
Miscellaneous databases
BioGRID-ORCSi | 73067, 1 hit in 17 CRISPR screens |
PROi | PR:Q9CXT7 |
RNActi | Q9CXT7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000025521, Expressed in ear and 266 other tissues |
ExpressionAtlasi | Q9CXT7, baseline and differential |
Genevisiblei | Q9CXT7, MM |
Family and domain databases
InterProi | View protein in InterPro IPR029399, TMEM192 |
PANTHERi | PTHR31592, PTHR31592, 1 hit |
Pfami | View protein in Pfam PF14802, TMEM192, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TM192_MOUSE | |
Accessioni | Q9CXT7Primary (citable) accession number: Q9CXT7 Secondary accession number(s): Q3THT5, Q8VDU8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 13, 2007 |
Last sequence update: | June 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 114 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families