Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Centromere protein V

Gene

Cenpv

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization, chromosome alignment and cytokinesis.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Centromere protein V
Short name:
CENP-V
Alternative name(s):
Proline-rich protein 6
Gene namesi
Name:Cenpv
Synonyms:Prr6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1920389 Cenpv

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002443601 – 252Centromere protein VAdd BLAST252

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18PhosphoserineCombined sources1
Modified residuei39Omega-N-methylarginineCombined sources1
Modified residuei78PhosphothreonineBy similarity1
Modified residuei234PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ9CXS4
PaxDbiQ9CXS4
PeptideAtlasiQ9CXS4
PRIDEiQ9CXS4

PTM databases

iPTMnetiQ9CXS4
PhosphoSitePlusiQ9CXS4
SwissPalmiQ9CXS4

Expressioni

Gene expression databases

BgeeiENSMUSG00000018509 Expressed in 271 organ(s), highest expression level in testis
ExpressionAtlasiQ9CXS4 baseline and differential
GenevisibleiQ9CXS4 MM

Interactioni

Protein-protein interaction databases

BioGridi215794, 3 interactors
IntActiQ9CXS4, 4 interactors
MINTiQ9CXS4
STRINGi10090.ENSMUSP00000018653

Structurei

3D structure databases

ProteinModelPortaliQ9CXS4
SMRiQ9CXS4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini148 – 221GFASequence analysisAdd BLAST74

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi41 – 47Poly-Gly7

Sequence similaritiesi

Belongs to the Gfa family.Curated

Phylogenomic databases

eggNOGiKOG4192 Eukaryota
COG3791 LUCA
GeneTreeiENSGT00390000003183
HOGENOMiHOG000090254
InParanoidiQ9CXS4
OMAiNGSNWEK
OrthoDBiEOG091G0YXV
PhylomeDBiQ9CXS4
TreeFamiTF313636

Family and domain databases

InterProiView protein in InterPro
IPR006913 GFA/CENP-V
IPR011057 Mss4-like_sf
PfamiView protein in Pfam
PF04828 GFA, 1 hit
SUPFAMiSSF51316 SSF51316, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9CXS4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRRTRSAVAT GPREQRRSGA TGGLSGGESR AQRSRSRTRA GAGGGGGAVG
60 70 80 90 100
PQPSAKPRPK PPPRAQEAAA EEPPPAVTPA ASVSALDLGE QRERWETFQK
110 120 130 140 150
RQRLSFEGAA KLLLDTFEYQ GLVKHTGGCH CGAVRFEVWA SADLHIFDCN
160 170 180 190 200
CSICKKKQNR HFIVPASRFK LLKGAESITT YTFNTHKAQH TFCKRCGVQS
210 220 230 240 250
FYTPRSNPGG FGIAPHCLDE GTVRSVVTEE FNGSDWERAM KEHKTIKNMS

KE
Length:252
Mass (Da):27,541
Last modified:June 27, 2006 - v2
Checksum:i8F63A72A21DAAE20
GO
Isoform 2 (identifier: Q9CXS4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-173: MRRTRSAVAT...VPASRFKLLK → MINVYLSLFSQ

Show »
Length:90
Mass (Da):10,180
Checksum:i3C18E14BF84D0D6E
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6SS03F6SS03_MOUSE
Centromere protein V
Cenpv
96Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti30R → P in BAB29130 (PubMed:16141072).Curated1
Sequence conflicti30R → P in AAH38868 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0195511 – 173MRRTR…FKLLK → MINVYLSLFSQ in isoform 2. 1 PublicationAdd BLAST173

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014046 mRNA Translation: BAB29130.1
AL596181 Genomic DNA Translation: CAI24673.1
CH466601 Genomic DNA Translation: EDL10349.1
BC038868 mRNA Translation: AAH38868.1
BC147794 mRNA Translation: AAI47795.1
BC147795 mRNA Translation: AAI47796.1
BC147835 mRNA Translation: AAI47836.1
BC147837 mRNA Translation: AAI47838.1
CCDSiCCDS48818.1 [Q9CXS4-1]
RefSeqiNP_082724.1, NM_028448.1 [Q9CXS4-1]
UniGeneiMm.390409
Mm.483809

Genome annotation databases

EnsembliENSMUST00000018653; ENSMUSP00000018653; ENSMUSG00000018509 [Q9CXS4-1]
GeneIDi73139
KEGGimmu:73139
UCSCiuc007jjf.2 mouse [Q9CXS4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014046 mRNA Translation: BAB29130.1
AL596181 Genomic DNA Translation: CAI24673.1
CH466601 Genomic DNA Translation: EDL10349.1
BC038868 mRNA Translation: AAH38868.1
BC147794 mRNA Translation: AAI47795.1
BC147795 mRNA Translation: AAI47796.1
BC147835 mRNA Translation: AAI47836.1
BC147837 mRNA Translation: AAI47838.1
CCDSiCCDS48818.1 [Q9CXS4-1]
RefSeqiNP_082724.1, NM_028448.1 [Q9CXS4-1]
UniGeneiMm.390409
Mm.483809

3D structure databases

ProteinModelPortaliQ9CXS4
SMRiQ9CXS4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi215794, 3 interactors
IntActiQ9CXS4, 4 interactors
MINTiQ9CXS4
STRINGi10090.ENSMUSP00000018653

PTM databases

iPTMnetiQ9CXS4
PhosphoSitePlusiQ9CXS4
SwissPalmiQ9CXS4

Proteomic databases

EPDiQ9CXS4
PaxDbiQ9CXS4
PeptideAtlasiQ9CXS4
PRIDEiQ9CXS4

Protocols and materials databases

DNASUi73139
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000018653; ENSMUSP00000018653; ENSMUSG00000018509 [Q9CXS4-1]
GeneIDi73139
KEGGimmu:73139
UCSCiuc007jjf.2 mouse [Q9CXS4-1]

Organism-specific databases

CTDi201161
MGIiMGI:1920389 Cenpv

Phylogenomic databases

eggNOGiKOG4192 Eukaryota
COG3791 LUCA
GeneTreeiENSGT00390000003183
HOGENOMiHOG000090254
InParanoidiQ9CXS4
OMAiNGSNWEK
OrthoDBiEOG091G0YXV
PhylomeDBiQ9CXS4
TreeFamiTF313636

Miscellaneous databases

ChiTaRSiCenpv mouse
PROiPR:Q9CXS4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000018509 Expressed in 271 organ(s), highest expression level in testis
ExpressionAtlasiQ9CXS4 baseline and differential
GenevisibleiQ9CXS4 MM

Family and domain databases

InterProiView protein in InterPro
IPR006913 GFA/CENP-V
IPR011057 Mss4-like_sf
PfamiView protein in Pfam
PF04828 GFA, 1 hit
SUPFAMiSSF51316 SSF51316, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCENPV_MOUSE
AccessioniPrimary (citable) accession number: Q9CXS4
Secondary accession number(s): B2RWK8
, B9EK22, Q5SX21, Q6PIA5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: October 10, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again