Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phosphatidylinositol N-acetylglucosaminyltransferase subunit C

Gene

Pigc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in GPI anchor biosynthesis. Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.By similarity

Catalytic activityi

UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol.

Pathwayi: glycosylphosphatidylinositol-anchor biosynthesis

This protein is involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis, which is part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis and in Glycolipid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processGPI-anchor biosynthesis

Enzyme and pathway databases

ReactomeiR-MMU-162710 Synthesis of glycosylphosphatidylinositol (GPI)
UniPathwayiUPA00196

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol N-acetylglucosaminyltransferase subunit C (EC:2.4.1.198)
Alternative name(s):
Phosphatidylinositol-glycan biosynthesis class C protein
Short name:
PIG-C
Gene namesi
Name:Pigc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1914542 Pigc

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei67 – 87HelicalSequence analysisAdd BLAST21
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Transmembranei153 – 173HelicalSequence analysisAdd BLAST21
Transmembranei239 – 259HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000584321 – 297Phosphatidylinositol N-acetylglucosaminyltransferase subunit CAdd BLAST297

Proteomic databases

PaxDbiQ9CXR4
PRIDEiQ9CXR4

PTM databases

PhosphoSitePlusiQ9CXR4

Expressioni

Gene expression databases

BgeeiENSMUSG00000026698
ExpressionAtlasiQ9CXR4 baseline and differential
GenevisibleiQ9CXR4 MM

Interactioni

Subunit structurei

Associates with PIGA, PIGH, PIGP, PIGQ and DPM2. The latter is not essential for activity (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028021

Structurei

3D structure databases

ProteinModelPortaliQ9CXR4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PIGC family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3059 Eukaryota
ENOG41112YY LUCA
GeneTreeiENSGT00390000005496
HOGENOMiHOG000194668
HOVERGENiHBG009071
InParanoidiQ9CXR4
KOiK03859
OMAiSYHAFVL
OrthoDBiEOG091G0M0J
PhylomeDBiQ9CXR4
TreeFamiTF314325

Family and domain databases

InterProiView protein in InterPro
IPR009450 Plno_GlcNAc_GPI2
PANTHERiPTHR12982 PTHR12982, 1 hit
PfamiView protein in Pfam
PF06432 GPI2, 1 hit
PIRSFiPIRSF016104 GPI2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CXR4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCAQRVTDTP EVKWQKVLYE RQPFPDNYVD QRFLEELRKN IYARKYQYWA
60 70 80 90 100
VVFESSVVIQ QLCSVCVFVV IWWYMDEGLL APQWLFGTGL ASSLVGYVLF
110 120 130 140 150
DLIDGGDGRK KSGRTRWADL KSTLVFITFT YGFSPVLKTL TESVSTDTIY
160 170 180 190 200
AMAVFMLLGH LIFFDYGANA AIVSSTLSLN MAIFASVCLA SRLPRSLHAF
210 220 230 240 250
IMVTFAIQIF ALWPMLQKKL KAYTPRSYVG VTLLFAFSAF GGLLSISAVG
260 270 280 290
AILFALLLFS ISCLCPYYLI HLQLFKENIH GPWDEAEIKE DLSRFLS
Length:297
Mass (Da):33,724
Last modified:June 1, 2001 - v1
Checksum:i3116EF0B412E58BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014096 mRNA Translation: BAB29152.1
AK152660 mRNA Translation: BAE31396.1
BC006938 mRNA Translation: AAH06938.1
CCDSiCCDS15419.1
RefSeqiNP_001034134.1, NM_001039045.1
NP_080354.1, NM_026078.2
XP_006497022.1, XM_006496959.2
UniGeneiMm.45106

Genome annotation databases

EnsembliENSMUST00000028021; ENSMUSP00000028021; ENSMUSG00000026698
ENSMUST00000111594; ENSMUSP00000107221; ENSMUSG00000026698
ENSMUST00000193784; ENSMUSP00000141646; ENSMUSG00000026698
GeneIDi67292
KEGGimmu:67292
UCSCiuc007dfx.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPIGC_MOUSE
AccessioniPrimary (citable) accession number: Q9CXR4
Secondary accession number(s): Q3U7H3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: June 1, 2001
Last modified: July 18, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health