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Protein

Dehydrogenase/reductase SDR family member 7

Gene

Dhrs7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei190SubstrateBy similarity1
Active sitei203Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi54 – 78NADBy similarityAdd BLAST25

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Dehydrogenase/reductase SDR family member 7 (EC:1.1.-.-)
Alternative name(s):
Retinal short-chain dehydrogenase/reductase 4
Short name:
retSDR4
Gene namesi
Name:Dhrs7
Synonyms:Retsdr4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1913625 Dhrs7

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000003196929 – 338Dehydrogenase/reductase SDR family member 7Add BLAST310

Proteomic databases

EPDiQ9CXR1
MaxQBiQ9CXR1
PaxDbiQ9CXR1
PeptideAtlasiQ9CXR1
PRIDEiQ9CXR1

PTM databases

iPTMnetiQ9CXR1
PhosphoSitePlusiQ9CXR1

Expressioni

Gene expression databases

BgeeiENSMUSG00000021094 Expressed in 256 organ(s), highest expression level in adrenal gland
CleanExiMM_DHRS7
ExpressionAtlasiQ9CXR1 baseline and differential
GenevisibleiQ9CXR1 MM

Interactioni

Protein-protein interaction databases

BioGridi211424, 1 interactor
IntActiQ9CXR1, 1 interactor
MINTiQ9CXR1
STRINGi10090.ENSMUSP00000021512

Structurei

3D structure databases

ProteinModelPortaliQ9CXR1
SMRiQ9CXR1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IUBT Eukaryota
COG0300 LUCA
GeneTreeiENSGT00930000150823
HOVERGENiHBG054346
InParanoidiQ9CXR1
KOiK11165
OrthoDBiEOG091G0N2V
PhylomeDBiQ9CXR1
TreeFamiTF354276

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9CXR1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSWELLLWLL ALCALILPLV QLLRFLRADA DLTLLWAEWQ GRRPEWELTD
60 70 80 90 100
MVVWVTGASS GIGEELAFQL SKLGVSLVLS ARRAQELERV KRRCLENGNL
110 120 130 140 150
KEKDILVLPL DLTDTSSHEA ATKAVLQEFG KIDILVNNGG RSQRSLVLET
160 170 180 190 200
NLDVFKELIN LNYIGTVSLT KCVLPHMIER KQGKIVTVNS IAGIASVSLS
210 220 230 240 250
SGYCASKHAL RGFFNALHSE LGQYPGITFC NVYPGPVQSD IVKNAFTEEV
260 270 280 290 300
TKSMRNNIDQ SYKMPTSRCV RLMLISMAND LKEVWISDHP VLLGAYIWQY
310 320 330
MPTWAAWLNC KLGKERIQNF KNNLDPDLPY KFLKAKKD
Length:338
Mass (Da):38,167
Last modified:August 29, 2003 - v2
Checksum:i5D12F0117BD1070D
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1Y7VN19A0A1Y7VN19_MOUSE
Dehydrogenase/reductase SDR family ...
Dhrs7
362Annotation score:
A0A1Y7VLS1A0A1Y7VLS1_MOUSE
Dehydrogenase/reductase SDR family ...
Dhrs7
96Annotation score:

Sequence cautioni

The sequence AAH16189 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB29156 differs from that shown. Reason: Frameshift at positions 11 and 15.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10L → R (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014100 mRNA Translation: BAB29156.1 Frameshift.
BC016189 mRNA Translation: AAH16189.1 Different initiation.
CCDSiCCDS49086.1
RefSeqiNP_079798.2, NM_025522.5
UniGeneiMm.289653

Genome annotation databases

EnsembliENSMUST00000021512; ENSMUSP00000021512; ENSMUSG00000021094
GeneIDi66375
KEGGimmu:66375
UCSCiuc007nvs.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014100 mRNA Translation: BAB29156.1 Frameshift.
BC016189 mRNA Translation: AAH16189.1 Different initiation.
CCDSiCCDS49086.1
RefSeqiNP_079798.2, NM_025522.5
UniGeneiMm.289653

3D structure databases

ProteinModelPortaliQ9CXR1
SMRiQ9CXR1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211424, 1 interactor
IntActiQ9CXR1, 1 interactor
MINTiQ9CXR1
STRINGi10090.ENSMUSP00000021512

PTM databases

iPTMnetiQ9CXR1
PhosphoSitePlusiQ9CXR1

Proteomic databases

EPDiQ9CXR1
MaxQBiQ9CXR1
PaxDbiQ9CXR1
PeptideAtlasiQ9CXR1
PRIDEiQ9CXR1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021512; ENSMUSP00000021512; ENSMUSG00000021094
GeneIDi66375
KEGGimmu:66375
UCSCiuc007nvs.2 mouse

Organism-specific databases

CTDi51635
MGIiMGI:1913625 Dhrs7

Phylogenomic databases

eggNOGiENOG410IUBT Eukaryota
COG0300 LUCA
GeneTreeiENSGT00930000150823
HOVERGENiHBG054346
InParanoidiQ9CXR1
KOiK11165
OrthoDBiEOG091G0N2V
PhylomeDBiQ9CXR1
TreeFamiTF354276

Miscellaneous databases

PROiPR:Q9CXR1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021094 Expressed in 256 organ(s), highest expression level in adrenal gland
CleanExiMM_DHRS7
ExpressionAtlasiQ9CXR1 baseline and differential
GenevisibleiQ9CXR1 MM

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDHRS7_MOUSE
AccessioniPrimary (citable) accession number: Q9CXR1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: August 29, 2003
Last modified: November 7, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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