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Protein

60S ribosome subunit biogenesis protein NIP7 homolog

Gene

Nip7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly.By similarity

GO - Molecular functioni

GO - Biological processi

  • ribosomal large subunit biogenesis Source: GO_Central
  • ribosome assembly Source: InterPro

Keywordsi

Molecular functionRNA-binding
Biological processRibosome biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosome subunit biogenesis protein NIP7 homolog
Alternative name(s):
PEachy
kDa93
Gene namesi
Name:Nip7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1913414 Nip7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002187741 – 18060S ribosome subunit biogenesis protein NIP7 homologAdd BLAST180

Proteomic databases

EPDiQ9CXK8
MaxQBiQ9CXK8
PaxDbiQ9CXK8
PeptideAtlasiQ9CXK8
PRIDEiQ9CXK8

PTM databases

iPTMnetiQ9CXK8
PhosphoSitePlusiQ9CXK8

Expressioni

Gene expression databases

BgeeiENSMUSG00000031917 Expressed in 301 organ(s), highest expression level in embryo
CleanExiMM_NIP7
ExpressionAtlasiQ9CXK8 baseline and differential
GenevisibleiQ9CXK8 MM

Interactioni

Subunit structurei

Monomer. Interacts with pre-ribosome complex. May bind to RNA. Interacts with NOL8. Interacts with FTSJ3 (By similarity).By similarity

Protein-protein interaction databases

BioGridi211262, 3 interactors
IntActiQ9CXK8, 2 interactors
MINTiQ9CXK8
STRINGi10090.ENSMUSP00000034392

Structurei

3D structure databases

ProteinModelPortaliQ9CXK8
SMRiQ9CXK8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini94 – 170PUAPROSITE-ProRule annotationAdd BLAST77

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 92N-terminal domainBy similarityAdd BLAST92
Regioni93 – 180C-terminal domainBy similarityAdd BLAST88

Sequence similaritiesi

Belongs to the NIP7 family.Curated

Phylogenomic databases

eggNOGiKOG3492 Eukaryota
COG1374 LUCA
GeneTreeiENSGT00390000003591
HOGENOMiHOG000168475
HOVERGENiHBG052625
InParanoidiQ9CXK8
KOiK07565
OMAiYKIWVKP
OrthoDBiEOG091G0NVA
PhylomeDBiQ9CXK8
TreeFamiTF300081

Family and domain databases

Gene3Di2.30.130.10, 1 hit
InterProiView protein in InterPro
IPR002478 PUA
IPR015947 PUA-like_sf
IPR036974 PUA_sf
IPR005155 Rbsml_synth_fac_NIP7-like
IPR016686 Ribosomal_synth_fac_NIP7
PfamiView protein in Pfam
PF03657 UPF0113, 1 hit
PIRSFiPIRSF017190 Rbsml_synth_fac_NIP7, 1 hit
SMARTiView protein in SMART
SM00359 PUA, 1 hit
SUPFAMiSSF88697 SSF88697, 1 hit
PROSITEiView protein in PROSITE
PS50890 PUA, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9CXK8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRPLTEEETR VMFEKIAKYI GENLQLLVDR PDGTYCFRLH NDRVYYVSEM
60 70 80 90 100
MLKLAANISG DKLVSLGTCF GKFTKTHKFR LHVTALDYLA PYAKYKVWVK
110 120 130 140 150
PGAEQSFLYG NHVLKSGLGR ITENTSQYQG VVVYSMADIP LGFGVAAKST
160 170 180
QDCRKVDPMA IVVFHQADIG EYVRHEETLT
Length:180
Mass (Da):20,452
Last modified:June 1, 2001 - v1
Checksum:i4F1256165370F2AF
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q109E9Q109_MOUSE
60S ribosome subunit biogenesis pro...
Nip7
133Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10R → P in BAB22972 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003739 mRNA Translation: BAB22972.1
AK014290 mRNA Translation: BAB29247.1
BC003972 mRNA Translation: AAH03972.1
CCDSiCCDS22644.1
RefSeqiNP_079667.2, NM_025391.2
UniGeneiMm.334789

Genome annotation databases

EnsembliENSMUST00000034392; ENSMUSP00000034392; ENSMUSG00000031917
GeneIDi66164
KEGGimmu:66164
UCSCiuc009ngz.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003739 mRNA Translation: BAB22972.1
AK014290 mRNA Translation: BAB29247.1
BC003972 mRNA Translation: AAH03972.1
CCDSiCCDS22644.1
RefSeqiNP_079667.2, NM_025391.2
UniGeneiMm.334789

3D structure databases

ProteinModelPortaliQ9CXK8
SMRiQ9CXK8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211262, 3 interactors
IntActiQ9CXK8, 2 interactors
MINTiQ9CXK8
STRINGi10090.ENSMUSP00000034392

PTM databases

iPTMnetiQ9CXK8
PhosphoSitePlusiQ9CXK8

Proteomic databases

EPDiQ9CXK8
MaxQBiQ9CXK8
PaxDbiQ9CXK8
PeptideAtlasiQ9CXK8
PRIDEiQ9CXK8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034392; ENSMUSP00000034392; ENSMUSG00000031917
GeneIDi66164
KEGGimmu:66164
UCSCiuc009ngz.2 mouse

Organism-specific databases

CTDi51388
MGIiMGI:1913414 Nip7

Phylogenomic databases

eggNOGiKOG3492 Eukaryota
COG1374 LUCA
GeneTreeiENSGT00390000003591
HOGENOMiHOG000168475
HOVERGENiHBG052625
InParanoidiQ9CXK8
KOiK07565
OMAiYKIWVKP
OrthoDBiEOG091G0NVA
PhylomeDBiQ9CXK8
TreeFamiTF300081

Miscellaneous databases

PROiPR:Q9CXK8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031917 Expressed in 301 organ(s), highest expression level in embryo
CleanExiMM_NIP7
ExpressionAtlasiQ9CXK8 baseline and differential
GenevisibleiQ9CXK8 MM

Family and domain databases

Gene3Di2.30.130.10, 1 hit
InterProiView protein in InterPro
IPR002478 PUA
IPR015947 PUA-like_sf
IPR036974 PUA_sf
IPR005155 Rbsml_synth_fac_NIP7-like
IPR016686 Ribosomal_synth_fac_NIP7
PfamiView protein in Pfam
PF03657 UPF0113, 1 hit
PIRSFiPIRSF017190 Rbsml_synth_fac_NIP7, 1 hit
SMARTiView protein in SMART
SM00359 PUA, 1 hit
SUPFAMiSSF88697 SSF88697, 1 hit
PROSITEiView protein in PROSITE
PS50890 PUA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNIP7_MOUSE
AccessioniPrimary (citable) accession number: Q9CXK8
Secondary accession number(s): Q9D1B4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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