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Protein

Sugar transporter SWEET1

Gene

Slc50a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mediates sugar transport across membranes (By similarity). May regulate the expression of RAG1 a gene involved in V(D)J recombination.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • positive regulation of gene expression, epigenetic Source: HGNC

Keywordsi

Biological processSugar transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-189200 Cellular hexose transport

Protein family/group databases

TCDBi2.A.123.1.8 the sweet, pq-loop, saliva, mtn3 (sweet) family

Names & Taxonomyi

Protein namesi
Recommended name:
Sugar transporter SWEET1
Short name:
MmSWEET1
Alternative name(s):
RAG1-activating protein 1
Solute carrier family 50 member 1
Gene namesi
Name:Slc50a1
Synonyms:Rag1ap1, Rga
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:107417 Slc50a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei3 – 23Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei43 – 63Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei68 – 88Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei102 – 122Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei129 – 149Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei160 – 180Helical; Name=6Sequence analysisAdd BLAST21
Transmembranei186 – 206Helical; Name=7Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003451171 – 221Sugar transporter SWEET1Add BLAST221

Proteomic databases

PaxDbiQ9CXK4
PRIDEiQ9CXK4

PTM databases

PhosphoSitePlusiQ9CXK4
SwissPalmiQ9CXK4

Expressioni

Tissue specificityi

Expressed at high levels in lung, placenta, spleen and thymus, at intermediate levels in brain, heart, kidney and testis, and at low levels in bone marrow, liver and lymph node. Within the thymus expression is highest in non-lymphoid cells.1 Publication

Inductioni

Up-regulated in mammary gland during lactation.1 Publication

Gene expression databases

BgeeiENSMUSG00000027953 Expressed in 267 organ(s), highest expression level in spleen
ExpressionAtlasiQ9CXK4 baseline and differential
GenevisibleiQ9CXK4 MM

Interactioni

Subunit structurei

Interacts with TRPV2; the interaction probably occurs intracellularly and depends on TRPV2 N-glycosylation.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029565

Structurei

3D structure databases

ProteinModelPortaliQ9CXK4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 94MtN3/slv 1Add BLAST85
Domaini127 – 212MtN3/slv 2Add BLAST86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni149 – 221Mediates interaction with TRPV2By similarityAdd BLAST73

Sequence similaritiesi

Belongs to the SWEET sugar transporter family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1623 Eukaryota
ENOG4111M4R LUCA
GeneTreeiENSGT00390000007801
HOVERGENiHBG055287
InParanoidiQ9CXK4
KOiK15382
OMAiVSMYLSP
OrthoDBiEOG091G0J82
PhylomeDBiQ9CXK4
TreeFamiTF313635

Family and domain databases

InterProiView protein in InterPro
IPR004316 SWEET_sugar_transpr
PfamiView protein in Pfam
PF03083 MtN3_slv, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9CXK4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAGGVADSF LSSACVLFTL GMFSTGLSDL RHMQRTRSVD NIQFLPFLTT
60 70 80 90 100
DVNNLSWLSY GVLKGDGTLI IVNSVGAVLQ TLYILAYLHY SPQKHGVLLQ
110 120 130 140 150
TATLLAVLLL GYGYFWLLVP DLEARLQQLG LFCSVFTISM YLSPLADLAK
160 170 180 190 200
IVQTKSTQRL SFSLTIATLF CSASWSIYGF RLRDPYITVP NLPGILTSLI
210 220
RLGLFCKYPP EQDRKYRLLQ T
Length:221
Mass (Da):24,649
Last modified:June 1, 2001 - v1
Checksum:i60FA342447ABA45C
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YXA7D3YXA7_MOUSE
Sugar transporter SWEET1
Slc50a1
167Annotation score:
D3Z071D3Z071_MOUSE
Sugar transporter SWEET1
Slc50a1
109Annotation score:
V9GXF7V9GXF7_MOUSE
Sugar transporter SWEET1
Slc50a1
87Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti188T → A in CAA65438 (PubMed:8630032).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96618 mRNA Translation: CAA65438.1
AK014305 mRNA Translation: BAB29259.1
AK170162 mRNA Translation: BAE41608.1
BC014292 mRNA Translation: AAH14292.1
CCDSiCCDS17500.1
PIRiJC4761
RefSeqiNP_033083.2, NM_009057.3
UniGeneiMm.17958

Genome annotation databases

EnsembliENSMUST00000029565; ENSMUSP00000029565; ENSMUSG00000027953
GeneIDi19729
KEGGimmu:19729
UCSCiuc008pyn.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96618 mRNA Translation: CAA65438.1
AK014305 mRNA Translation: BAB29259.1
AK170162 mRNA Translation: BAE41608.1
BC014292 mRNA Translation: AAH14292.1
CCDSiCCDS17500.1
PIRiJC4761
RefSeqiNP_033083.2, NM_009057.3
UniGeneiMm.17958

3D structure databases

ProteinModelPortaliQ9CXK4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029565

Protein family/group databases

TCDBi2.A.123.1.8 the sweet, pq-loop, saliva, mtn3 (sweet) family

PTM databases

PhosphoSitePlusiQ9CXK4
SwissPalmiQ9CXK4

Proteomic databases

PaxDbiQ9CXK4
PRIDEiQ9CXK4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029565; ENSMUSP00000029565; ENSMUSG00000027953
GeneIDi19729
KEGGimmu:19729
UCSCiuc008pyn.2 mouse

Organism-specific databases

CTDi55974
MGIiMGI:107417 Slc50a1

Phylogenomic databases

eggNOGiKOG1623 Eukaryota
ENOG4111M4R LUCA
GeneTreeiENSGT00390000007801
HOVERGENiHBG055287
InParanoidiQ9CXK4
KOiK15382
OMAiVSMYLSP
OrthoDBiEOG091G0J82
PhylomeDBiQ9CXK4
TreeFamiTF313635

Enzyme and pathway databases

ReactomeiR-MMU-189200 Cellular hexose transport

Miscellaneous databases

PROiPR:Q9CXK4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027953 Expressed in 267 organ(s), highest expression level in spleen
ExpressionAtlasiQ9CXK4 baseline and differential
GenevisibleiQ9CXK4 MM

Family and domain databases

InterProiView protein in InterPro
IPR004316 SWEET_sugar_transpr
PfamiView protein in Pfam
PF03083 MtN3_slv, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSWET1_MOUSE
AccessioniPrimary (citable) accession number: Q9CXK4
Secondary accession number(s): Q62275
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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