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Protein

Peptidyl-prolyl cis-trans isomerase-like 4

Gene

Ppil4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase, RNA-binding, Rotamase

Enzyme and pathway databases

ReactomeiR-MMU-72163 mRNA Splicing - Major Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase-like 4 (EC:5.2.1.8)
Short name:
PPIase
Alternative name(s):
Cyclophilin-like protein PPIL4
Rotamase PPIL4
Gene namesi
Name:Ppil4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1914668 Ppil4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002330531 – 492Peptidyl-prolyl cis-trans isomerase-like 4Add BLAST492

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei178PhosphoserineCombined sources1
Modified residuei182PhosphothreonineBy similarity1
Cross-linki201Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki212Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki218Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki321Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki362Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei393PhosphoserineCombined sources1
Cross-linki405Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki460Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei471PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9CXG3
MaxQBiQ9CXG3
PaxDbiQ9CXG3
PeptideAtlasiQ9CXG3
PRIDEiQ9CXG3

PTM databases

iPTMnetiQ9CXG3
PhosphoSitePlusiQ9CXG3

Expressioni

Gene expression databases

BgeeiENSMUSG00000015757
CleanExiMM_PPIL4
ExpressionAtlasiQ9CXG3 baseline and differential
GenevisibleiQ9CXG3 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000015901

Structurei

3D structure databases

ProteinModelPortaliQ9CXG3
SMRiQ9CXG3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 161PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST161
Domaini240 – 318RRMPROSITE-ProRule annotationAdd BLAST79

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi321 – 388Lys-richAdd BLAST68

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0415 Eukaryota
COG0652 LUCA
GeneTreeiENSGT00760000119072
HOGENOMiHOG000186284
HOVERGENiHBG057731
InParanoidiQ9CXG3
KOiK12735
OMAiHSVQKNF
OrthoDBiEOG091G0DCF
PhylomeDBiQ9CXG3
TreeFamiTF351865

Family and domain databases

CDDicd01921 cyclophilin_RRM, 1 hit
Gene3Di2.40.100.10, 1 hit
3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR035542 CRIP
IPR029000 Cyclophilin-like_dom_sf
IPR024936 Cyclophilin-type_PPIase
IPR002130 Cyclophilin-type_PPIase_dom
IPR035538 Cyclophilin_PPIL4
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PANTHERiPTHR11071 PTHR11071, 1 hit
PTHR11071:SF156 PTHR11071:SF156, 1 hit
PfamiView protein in Pfam
PF00160 Pro_isomerase, 1 hit
PF00076 RRM_1, 1 hit
PRINTSiPR00153 CSAPPISMRASE
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF50891 SSF50891, 1 hit
SSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50072 CSA_PPIASE_2, 1 hit
PS50102 RRM, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CXG3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVLLETTLG DVVIDLYTEE RPRACLNFLK LCKIKYYNYC LIHNVQRDFI
60 70 80 90 100
IQTGDPTGTG RGGESIFGQL YGDQASFFEA EKVPRIKHKK KGTVSMVNNG
110 120 130 140 150
SDQHGSQFLI TTGENLDYLD GVHTVFGEVT EGMDIVKKIN ETFVDKDFVP
160 170 180 190 200
YQDIRINHTV ILDDPFDDPP DLLIPDRSPE PTKEQLDSGR IGADEEIDDF
210 220 230 240 250
KGRSAEEVEE IKAEKEAKTQ AILLEMVGDL PDADIKPPEN VLFVCKLNPV
260 270 280 290 300
TTDEDLEIIF SRFGPIRSCE VIRDWKTGES LCYAFIEFEK EEDCEKAFFK
310 320 330 340 350
MDNVLIDDRR IHVDFSQSVA KVKWKGKGGK YTKSDFKEYE KEQDKPANLV
360 370 380 390 400
LKEKVKPKQD AKYDLILDEQ GEDSKSSHSH TSKKHKKKTR HCSEEKEDEE
410 420 430 440 450
YMPIKNPNQD IYREMGFGHY EEEESCWEKQ KNEKRDRRQN RSRSRSRERD
460 470 480 490
GHYSNSHKPK YQTEPYERER SRKRDRSRSP KKSKAKEKSK YR
Length:492
Mass (Da):57,230
Last modified:April 18, 2006 - v2
Checksum:i8938D66664EF640E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti234D → E in BAB29330 (PubMed:16141072).Curated1
Sequence conflicti258I → L in BAB29330 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011443 mRNA Translation: BAB27623.1
AK014406 mRNA Translation: BAB29330.1
AK167258 mRNA Translation: BAE39374.1
BC079912 mRNA Translation: AAH79912.1
CCDSiCCDS23690.1
RefSeqiNP_080417.2, NM_026141.3
UniGeneiMm.38927

Genome annotation databases

EnsembliENSMUST00000015901; ENSMUSP00000015901; ENSMUSG00000015757
GeneIDi67418
KEGGimmu:67418
UCSCiuc007eip.2 mouse

Similar proteinsi

Entry informationi

Entry nameiPPIL4_MOUSE
AccessioniPrimary (citable) accession number: Q9CXG3
Secondary accession number(s): Q3TJX1, Q68FC7, Q9CT22
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: April 18, 2006
Last modified: July 18, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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