Tbc1d15

Functionⁱ

Acts as a GTPase activating protein for RAB7A. Does not act on RAB4, RAB5 or RAB6.2 Publications

Caution

PubMed:16055087 showns that TBC1D15 can also functions as GTPase activating for RAB11 at a lower extent than for RAB7A, however this function is not confirmed by PubMed:20363736.Curated

GO - Molecular functionⁱ

GTPase activator activity
Source: UniProtKB
Inferred from direct assayⁱ
- 16055087
Rab GTPase binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of GTPase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
intracellular protein transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of GTPase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 16055087

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	GTPase activation

Molecular function

GTPase activation

Enzyme and pathway databases

Reactomeⁱ	R-MMU-8854214 TBC/RABGAPs

Reactomeⁱ

R-MMU-8854214 TBC/RABGAPs

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: TBC1 domain family member 15 Alternative name(s): GTPase-activating protein RAB7 Short name: GAP for RAB7 Short name: Rab7-GAP
Gene namesⁱ	Name:Tbc1d15
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 10

Organism-specific databases

MGIⁱ	MGI:1913937 Tbc1d15

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedBy similarity
ChainⁱPRO_0000208043	2 – 671	TBC1 domain family member 15Add BLAST		670

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineBy similarity	1
Modified residueⁱ	23	PhosphoserineBy similarity	1
Modified residueⁱ	32	PhosphoserineCombined sources	1
Modified residueⁱ	70	PhosphoserineBy similarity	1
Modified residueⁱ	205	PhosphoserineCombined sources	1
Modified residueⁱ	257	PhosphoserineBy similarity	1
Modified residueⁱ	623	PhosphoserineBy similarity	1
Modified residueⁱ	655	PhosphoserineBy similarity	1
Modified residueⁱ	669	PhosphothreonineBy similarity	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q9CXF4
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9CXF4
PaxDbⁱ	Q9CXF4
PRIDEⁱ	Q9CXF4

PTM databases

iPTMnetⁱ	Q9CXF4
PhosphoSitePlusⁱ	Q9CXF4
SwissPalmⁱ	Q9CXF4

Expressionⁱ

Tissue specificityⁱ

Ubiquitous, with highest expression in heart, liver and testis and lower expression in brain, spleen, lung, kidney and skeletal muscle.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000020130 Expressed in 292 organ(s), highest expression level in secondary oocyte
CleanExⁱ	MM_TBC1D15
Genevisibleⁱ	Q9CXF4 MM

Interactionⁱ

GO - Molecular functionⁱ

Rab GTPase binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	211646, 2 interactors
IntActⁱ	Q9CXF4, 2 interactors
STRINGⁱ	10090.ENSMUSP00000020339

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9CXF4
SMRⁱ	Q9CXF4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	329 – 539	Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST		211

Phylogenomic databases

eggNOGⁱ	KOG2197 Eukaryota COG5210 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074386
HOGENOMⁱ	HOG000012710
HOVERGENⁱ	HBG057668
InParanoidⁱ	Q9CXF4
KEGG Orthology (KO) More...KOⁱ	K20168
OMAⁱ	FKGGLCH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G04IX
PhylomeDBⁱ	Q9CXF4
TreeFamⁱ	TF314296

Family and domain databases

InterProⁱ	View protein in InterPro IPR021935 DUF3548 IPR000195 Rab-GTPase-TBC_dom IPR035969 Rab-GTPase_TBC_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12068 DUF3548, 1 hit PF00566 RabGAP-TBC, 1 hit
SMARTⁱ	View protein in SMART SM00164 TBC, 1 hit
SUPFAMⁱ	SSF47923 SSF47923, 2 hits
PROSITEⁱ	View protein in PROSITE PS50086 TBC_RABGAP, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q9CXF4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAAAGVVSGK IIYEQEGVYI HSSCGKANDQ DSLISGILRV LEKDAEVIVD 
        60         70         80         90        100
WRPLDDALDS SSILCAGKDS SSVVEWTQAP KERAHRGSDQ QSSYEAEWDM 
       110        120        130        140        150
VTTVSFKKKP HTNGDAPGHR NGKSKWSFLF SLADLKSVKQ SKEGMGWSYL 
       160        170        180        190        200
VFCLKDDVML PALHFHQGDS KLLIESLEKY VVLCESPQDS RTLLVNCQNK 
       210        220        230        240        250
SLSQSFENLL DEPAYGLIQK IKKDPYTATM VGFSKVTNYI FDSLRGSDPS 
       260        270        280        290        300
THQRPPSEMA DFLSDAIPGL KINQQEEPGF EVITRIDLGE RPVVQRREPV 
       310        320        330        340        350
SLEEWNKSLD PEGRLVAVES MKQKIFRGGL SHSLRKQAWK FLLGYFPWDS 
       360        370        380        390        400
TKEERTQLQK QKTDEYFRMK LQWKSVSEAQ EKRNSRLRDY RSLIEKDVNR 
       410        420        430        440        450
TDRTNKFYEG QDNPGLILLH DILMTYCMYD FDLGYVQGMS DLLSPLLYVM 
       460        470        480        490        500
ENEVDAFWCF ASYMDQMHQN FEEQMQGMKT QLIQLSTLLR LLDSGFCSYL 
       510        520        530        540        550
ESQDSGYLYF CFRWLLIRFK REFSFLDILR LWEVMWTELP CKNFHLLLCC 
       560        570        580        590        600
AILESEKQQI MAKHYGFNEI LKHINELSMK IDVEDILCKA EAISLQMAQC 
       610        620        630        640        650
KELPQAVCEI LGLQDSEITT PDSDTDENVG SPCPVSAFPS STLPILAASE 
       660        670 
AKDDSPTQTL ASPNACRLTP A

Length:671

Mass (Da):76,527

Last modified:June 1, 2001 - v1

Checksum:ⁱA822B14AE4268FDE

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK014477 mRNA Translation: BAB29380.1 AK078875 mRNA Translation: BAC37435.1 AK147085 mRNA Translation: BAE27665.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS24176.1
NCBI Reference Sequences More...RefSeqⁱ	NP_079982.3, NM_025706.3
UniGeneⁱ	Mm.22252

Genome annotation databases

Ensemblⁱ	ENSMUST00000020339; ENSMUSP00000020339; ENSMUSG00000020130
GeneIDⁱ	66687
KEGGⁱ	mmu:66687
UCSC genome browser More...UCSCⁱ	uc007hax.2 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9CXF4	TBC1 domain family, member 15		MOUSE		671	UniRef90_Q9CXF4
TBC1 domain family member 15		CRIGR		139
UPI000A311510		MUSPA		671
UPI000A315FB4		MUSCR		670
TBC1 domain family member 15		MOUSE		671
+1

Protein	Similar proteins		Species	Score	Length	Source
Q9CXF4	TBC1 domain family member 15		HUMAN		691	UniRef50_Q8TC07
Uncharacterized protein		CALJA		720
Uncharacterized protein		RHIRO		71
TBC1 domain family member 15		PANTR		713
Uncharacterized protein		AOTNA		713
+435

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK014477 mRNA Translation: BAB29380.1 AK078875 mRNA Translation: BAC37435.1 AK147085 mRNA Translation: BAE27665.1
CCDSⁱ	CCDS24176.1
RefSeqⁱ	NP_079982.3, NM_025706.3
UniGeneⁱ	Mm.22252

3D structure databases

ProteinModelPortalⁱ	Q9CXF4
SMRⁱ	Q9CXF4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	211646, 2 interactors
IntActⁱ	Q9CXF4, 2 interactors
STRINGⁱ	10090.ENSMUSP00000020339

PTM databases

iPTMnetⁱ	Q9CXF4
PhosphoSitePlusⁱ	Q9CXF4
SwissPalmⁱ	Q9CXF4

Proteomic databases

EPDⁱ	Q9CXF4
MaxQBⁱ	Q9CXF4
PaxDbⁱ	Q9CXF4
PRIDEⁱ	Q9CXF4

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000020339; ENSMUSP00000020339; ENSMUSG00000020130
GeneIDⁱ	66687
KEGGⁱ	mmu:66687
UCSCⁱ	uc007hax.2 mouse

Organism-specific databases

CTDⁱ	64786
MGIⁱ	MGI:1913937 Tbc1d15

Phylogenomic databases

eggNOGⁱ	KOG2197 Eukaryota COG5210 LUCA
GeneTreeⁱ	ENSGT00550000074386
HOGENOMⁱ	HOG000012710
HOVERGENⁱ	HBG057668
InParanoidⁱ	Q9CXF4
KOⁱ	K20168
OMAⁱ	FKGGLCH
OrthoDBⁱ	EOG091G04IX
PhylomeDBⁱ	Q9CXF4
TreeFamⁱ	TF314296

Enzyme and pathway databases

Reactomeⁱ	R-MMU-8854214 TBC/RABGAPs

Reactomeⁱ

R-MMU-8854214 TBC/RABGAPs

Miscellaneous databases

ChiTaRSⁱ	Tbc1d15 mouse
Protein Ontology More...PROⁱ	PR:Q9CXF4
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000020130 Expressed in 292 organ(s), highest expression level in secondary oocyte
CleanExⁱ	MM_TBC1D15
Genevisibleⁱ	Q9CXF4 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR021935 DUF3548 IPR000195 Rab-GTPase-TBC_dom IPR035969 Rab-GTPase_TBC_sf
Pfamⁱ	View protein in Pfam PF12068 DUF3548, 1 hit PF00566 RabGAP-TBC, 1 hit
SMARTⁱ	View protein in SMART SM00164 TBC, 1 hit
SUPFAMⁱ	SSF47923 SSF47923, 2 hits
PROSITEⁱ	View protein in PROSITE PS50086 TBC_RABGAP, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TBC15_MOUSE
Accessionⁱ	Q9CXF4Primary (citable) accession number: Q9CXF4 Secondary accession number(s): Q3UI41
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 15, 2005
	Last sequence update:	June 1, 2001
	Last modified:	November 7, 2018
	This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9CXF4 (TBC15_MOUSE)

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TBC1 domain family member 15

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Extracellular region or secreted

Mitochondrion

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ