UniProtKB - Q9CXF4 (TBC15_MOUSE)
Protein
TBC1 domain family member 15
Gene
Tbc1d15
Organism
Mus musculus (Mouse)
Status
Functioni
Acts as a GTPase activating protein for RAB7A. Does not act on RAB4, RAB5 or RAB6.2 Publications
Caution
PubMed:16055087 showns that TBC1D15 can also functions as GTPase activating for RAB11 at a lower extent than for RAB7A, however this function is not confirmed by PubMed:20363736.Curated
GO - Molecular functioni
- GTPase activator activity Source: UniProtKB
- Rab GTPase binding Source: GO_Central
GO - Biological processi
- activation of GTPase activity Source: GO_Central
- intracellular protein transport Source: GO_Central
- regulation of GTPase activity Source: UniProtKB
Keywordsi
Molecular function | GTPase activation |
Enzyme and pathway databases
Reactomei | R-MMU-8854214 TBC/RABGAPs |
Names & Taxonomyi
Protein namesi | Recommended name: TBC1 domain family member 15Alternative name(s): GTPase-activating protein RAB7 Short name: GAP for RAB7 Short name: Rab7-GAP |
Gene namesi | Name:Tbc1d15 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1913937 Tbc1d15 |
Subcellular locationi
Other locations
- Cytoplasm 1 Publication
Extracellular region or secreted
- extracellular region Source: MGI
Mitochondrion
- mitochondrion Source: MGI
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000208043 | 2 – 671 | TBC1 domain family member 15Add BLAST | 670 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 | |
Modified residuei | 23 | PhosphoserineBy similarity | 1 | |
Modified residuei | 32 | PhosphoserineCombined sources | 1 | |
Modified residuei | 70 | PhosphoserineBy similarity | 1 | |
Modified residuei | 205 | PhosphoserineCombined sources | 1 | |
Modified residuei | 257 | PhosphoserineBy similarity | 1 | |
Modified residuei | 623 | PhosphoserineBy similarity | 1 | |
Modified residuei | 655 | PhosphoserineBy similarity | 1 | |
Modified residuei | 669 | PhosphothreonineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q9CXF4 |
jPOSTi | Q9CXF4 |
MaxQBi | Q9CXF4 |
PaxDbi | Q9CXF4 |
PRIDEi | Q9CXF4 |
PTM databases
iPTMneti | Q9CXF4 |
PhosphoSitePlusi | Q9CXF4 |
SwissPalmi | Q9CXF4 |
Expressioni
Tissue specificityi
Ubiquitous, with highest expression in heart, liver and testis and lower expression in brain, spleen, lung, kidney and skeletal muscle.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000020130 Expressed in 292 organ(s), highest expression level in secondary oocyte |
Genevisiblei | Q9CXF4 MM |
Interactioni
Subunit structurei
Interacts with non-phosphorylated form of RAB8A; phosphorylation of RAB8A at 'Thr-72' disrupts this interaction.
By similarityGO - Molecular functioni
- Rab GTPase binding Source: GO_Central
Protein-protein interaction databases
BioGridi | 211646, 2 interactors |
IntActi | Q9CXF4, 2 interactors |
STRINGi | 10090.ENSMUSP00000020339 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 329 – 539 | Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST | 211 |
Phylogenomic databases
eggNOGi | KOG2197 Eukaryota COG5210 LUCA |
GeneTreei | ENSGT00940000156429 |
HOGENOMi | HOG000012710 |
InParanoidi | Q9CXF4 |
KOi | K20168 |
OMAi | AISMQMM |
OrthoDBi | 1495285at2759 |
PhylomeDBi | Q9CXF4 |
TreeFami | TF314296 |
Family and domain databases
InterProi | View protein in InterPro IPR000195 Rab-GTPase-TBC_dom IPR035969 Rab-GTPase_TBC_sf IPR021935 SGSM1/2_RBD |
Pfami | View protein in Pfam PF12068 PH_RBD, 1 hit PF00566 RabGAP-TBC, 1 hit |
SMARTi | View protein in SMART SM00164 TBC, 1 hit |
SUPFAMi | SSF47923 SSF47923, 2 hits |
PROSITEi | View protein in PROSITE PS50086 TBC_RABGAP, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9CXF4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAAGVVSGK IIYEQEGVYI HSSCGKANDQ DSLISGILRV LEKDAEVIVD
60 70 80 90 100
WRPLDDALDS SSILCAGKDS SSVVEWTQAP KERAHRGSDQ QSSYEAEWDM
110 120 130 140 150
VTTVSFKKKP HTNGDAPGHR NGKSKWSFLF SLADLKSVKQ SKEGMGWSYL
160 170 180 190 200
VFCLKDDVML PALHFHQGDS KLLIESLEKY VVLCESPQDS RTLLVNCQNK
210 220 230 240 250
SLSQSFENLL DEPAYGLIQK IKKDPYTATM VGFSKVTNYI FDSLRGSDPS
260 270 280 290 300
THQRPPSEMA DFLSDAIPGL KINQQEEPGF EVITRIDLGE RPVVQRREPV
310 320 330 340 350
SLEEWNKSLD PEGRLVAVES MKQKIFRGGL SHSLRKQAWK FLLGYFPWDS
360 370 380 390 400
TKEERTQLQK QKTDEYFRMK LQWKSVSEAQ EKRNSRLRDY RSLIEKDVNR
410 420 430 440 450
TDRTNKFYEG QDNPGLILLH DILMTYCMYD FDLGYVQGMS DLLSPLLYVM
460 470 480 490 500
ENEVDAFWCF ASYMDQMHQN FEEQMQGMKT QLIQLSTLLR LLDSGFCSYL
510 520 530 540 550
ESQDSGYLYF CFRWLLIRFK REFSFLDILR LWEVMWTELP CKNFHLLLCC
560 570 580 590 600
AILESEKQQI MAKHYGFNEI LKHINELSMK IDVEDILCKA EAISLQMAQC
610 620 630 640 650
KELPQAVCEI LGLQDSEITT PDSDTDENVG SPCPVSAFPS STLPILAASE
660 670
AKDDSPTQTL ASPNACRLTP A
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK014477 mRNA Translation: BAB29380.1 AK078875 mRNA Translation: BAC37435.1 AK147085 mRNA Translation: BAE27665.1 |
CCDSi | CCDS24176.1 |
RefSeqi | NP_079982.3, NM_025706.3 |
Genome annotation databases
Ensembli | ENSMUST00000020339; ENSMUSP00000020339; ENSMUSG00000020130 |
GeneIDi | 66687 |
KEGGi | mmu:66687 |
UCSCi | uc007hax.2 mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK014477 mRNA Translation: BAB29380.1 AK078875 mRNA Translation: BAC37435.1 AK147085 mRNA Translation: BAE27665.1 |
CCDSi | CCDS24176.1 |
RefSeqi | NP_079982.3, NM_025706.3 |
3D structure databases
SMRi | Q9CXF4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGridi | 211646, 2 interactors |
IntActi | Q9CXF4, 2 interactors |
STRINGi | 10090.ENSMUSP00000020339 |
PTM databases
iPTMneti | Q9CXF4 |
PhosphoSitePlusi | Q9CXF4 |
SwissPalmi | Q9CXF4 |
Proteomic databases
EPDi | Q9CXF4 |
jPOSTi | Q9CXF4 |
MaxQBi | Q9CXF4 |
PaxDbi | Q9CXF4 |
PRIDEi | Q9CXF4 |
Genome annotation databases
Ensembli | ENSMUST00000020339; ENSMUSP00000020339; ENSMUSG00000020130 |
GeneIDi | 66687 |
KEGGi | mmu:66687 |
UCSCi | uc007hax.2 mouse |
Organism-specific databases
CTDi | 64786 |
MGIi | MGI:1913937 Tbc1d15 |
Phylogenomic databases
eggNOGi | KOG2197 Eukaryota COG5210 LUCA |
GeneTreei | ENSGT00940000156429 |
HOGENOMi | HOG000012710 |
InParanoidi | Q9CXF4 |
KOi | K20168 |
OMAi | AISMQMM |
OrthoDBi | 1495285at2759 |
PhylomeDBi | Q9CXF4 |
TreeFami | TF314296 |
Enzyme and pathway databases
Reactomei | R-MMU-8854214 TBC/RABGAPs |
Miscellaneous databases
ChiTaRSi | Tbc1d15 mouse |
PROi | PR:Q9CXF4 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000020130 Expressed in 292 organ(s), highest expression level in secondary oocyte |
Genevisiblei | Q9CXF4 MM |
Family and domain databases
InterProi | View protein in InterPro IPR000195 Rab-GTPase-TBC_dom IPR035969 Rab-GTPase_TBC_sf IPR021935 SGSM1/2_RBD |
Pfami | View protein in Pfam PF12068 PH_RBD, 1 hit PF00566 RabGAP-TBC, 1 hit |
SMARTi | View protein in SMART SM00164 TBC, 1 hit |
SUPFAMi | SSF47923 SSF47923, 2 hits |
PROSITEi | View protein in PROSITE PS50086 TBC_RABGAP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TBC15_MOUSE | |
Accessioni | Q9CXF4Primary (citable) accession number: Q9CXF4 Secondary accession number(s): Q3UI41 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 15, 2005 |
Last sequence update: | June 1, 2001 | |
Last modified: | October 16, 2019 | |
This is version 127 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot