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Protein

TBC1 domain family member 15

Gene

Tbc1d15

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a GTPase activating protein for RAB7A. Does not act on RAB4, RAB5 or RAB6.2 Publications

Caution

PubMed:16055087 showns that TBC1D15 can also functions as GTPase activating for RAB11 at a lower extent than for RAB7A, however this function is not confirmed by PubMed:20363736.Curated

GO - Molecular functioni

  • GTPase activator activity Source: UniProtKB
  • Rab GTPase binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

ReactomeiR-MMU-8854214 TBC/RABGAPs

Names & Taxonomyi

Protein namesi
Recommended name:
TBC1 domain family member 15
Alternative name(s):
GTPase-activating protein RAB7
Short name:
GAP for RAB7
Short name:
Rab7-GAP
Gene namesi
Name:Tbc1d15
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1913937 Tbc1d15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002080432 – 671TBC1 domain family member 15Add BLAST670

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei23PhosphoserineBy similarity1
Modified residuei32PhosphoserineCombined sources1
Modified residuei70PhosphoserineBy similarity1
Modified residuei205PhosphoserineCombined sources1
Modified residuei257PhosphoserineBy similarity1
Modified residuei623PhosphoserineBy similarity1
Modified residuei655PhosphoserineBy similarity1
Modified residuei669PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9CXF4
MaxQBiQ9CXF4
PaxDbiQ9CXF4
PRIDEiQ9CXF4

PTM databases

iPTMnetiQ9CXF4
PhosphoSitePlusiQ9CXF4
SwissPalmiQ9CXF4

Expressioni

Tissue specificityi

Ubiquitous, with highest expression in heart, liver and testis and lower expression in brain, spleen, lung, kidney and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSMUSG00000020130 Expressed in 292 organ(s), highest expression level in secondary oocyte
CleanExiMM_TBC1D15
GenevisibleiQ9CXF4 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211646, 2 interactors
IntActiQ9CXF4, 2 interactors
STRINGi10090.ENSMUSP00000020339

Structurei

3D structure databases

ProteinModelPortaliQ9CXF4
SMRiQ9CXF4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini329 – 539Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST211

Phylogenomic databases

eggNOGiKOG2197 Eukaryota
COG5210 LUCA
GeneTreeiENSGT00550000074386
HOGENOMiHOG000012710
HOVERGENiHBG057668
InParanoidiQ9CXF4
KOiK20168
OMAiFKGGLCH
OrthoDBiEOG091G04IX
PhylomeDBiQ9CXF4
TreeFamiTF314296

Family and domain databases

InterProiView protein in InterPro
IPR021935 DUF3548
IPR000195 Rab-GTPase-TBC_dom
IPR035969 Rab-GTPase_TBC_sf
PfamiView protein in Pfam
PF12068 DUF3548, 1 hit
PF00566 RabGAP-TBC, 1 hit
SMARTiView protein in SMART
SM00164 TBC, 1 hit
SUPFAMiSSF47923 SSF47923, 2 hits
PROSITEiView protein in PROSITE
PS50086 TBC_RABGAP, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CXF4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAGVVSGK IIYEQEGVYI HSSCGKANDQ DSLISGILRV LEKDAEVIVD
60 70 80 90 100
WRPLDDALDS SSILCAGKDS SSVVEWTQAP KERAHRGSDQ QSSYEAEWDM
110 120 130 140 150
VTTVSFKKKP HTNGDAPGHR NGKSKWSFLF SLADLKSVKQ SKEGMGWSYL
160 170 180 190 200
VFCLKDDVML PALHFHQGDS KLLIESLEKY VVLCESPQDS RTLLVNCQNK
210 220 230 240 250
SLSQSFENLL DEPAYGLIQK IKKDPYTATM VGFSKVTNYI FDSLRGSDPS
260 270 280 290 300
THQRPPSEMA DFLSDAIPGL KINQQEEPGF EVITRIDLGE RPVVQRREPV
310 320 330 340 350
SLEEWNKSLD PEGRLVAVES MKQKIFRGGL SHSLRKQAWK FLLGYFPWDS
360 370 380 390 400
TKEERTQLQK QKTDEYFRMK LQWKSVSEAQ EKRNSRLRDY RSLIEKDVNR
410 420 430 440 450
TDRTNKFYEG QDNPGLILLH DILMTYCMYD FDLGYVQGMS DLLSPLLYVM
460 470 480 490 500
ENEVDAFWCF ASYMDQMHQN FEEQMQGMKT QLIQLSTLLR LLDSGFCSYL
510 520 530 540 550
ESQDSGYLYF CFRWLLIRFK REFSFLDILR LWEVMWTELP CKNFHLLLCC
560 570 580 590 600
AILESEKQQI MAKHYGFNEI LKHINELSMK IDVEDILCKA EAISLQMAQC
610 620 630 640 650
KELPQAVCEI LGLQDSEITT PDSDTDENVG SPCPVSAFPS STLPILAASE
660 670
AKDDSPTQTL ASPNACRLTP A
Length:671
Mass (Da):76,527
Last modified:June 1, 2001 - v1
Checksum:iA822B14AE4268FDE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014477 mRNA Translation: BAB29380.1
AK078875 mRNA Translation: BAC37435.1
AK147085 mRNA Translation: BAE27665.1
CCDSiCCDS24176.1
RefSeqiNP_079982.3, NM_025706.3
UniGeneiMm.22252

Genome annotation databases

EnsembliENSMUST00000020339; ENSMUSP00000020339; ENSMUSG00000020130
GeneIDi66687
KEGGimmu:66687
UCSCiuc007hax.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014477 mRNA Translation: BAB29380.1
AK078875 mRNA Translation: BAC37435.1
AK147085 mRNA Translation: BAE27665.1
CCDSiCCDS24176.1
RefSeqiNP_079982.3, NM_025706.3
UniGeneiMm.22252

3D structure databases

ProteinModelPortaliQ9CXF4
SMRiQ9CXF4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211646, 2 interactors
IntActiQ9CXF4, 2 interactors
STRINGi10090.ENSMUSP00000020339

PTM databases

iPTMnetiQ9CXF4
PhosphoSitePlusiQ9CXF4
SwissPalmiQ9CXF4

Proteomic databases

EPDiQ9CXF4
MaxQBiQ9CXF4
PaxDbiQ9CXF4
PRIDEiQ9CXF4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020339; ENSMUSP00000020339; ENSMUSG00000020130
GeneIDi66687
KEGGimmu:66687
UCSCiuc007hax.2 mouse

Organism-specific databases

CTDi64786
MGIiMGI:1913937 Tbc1d15

Phylogenomic databases

eggNOGiKOG2197 Eukaryota
COG5210 LUCA
GeneTreeiENSGT00550000074386
HOGENOMiHOG000012710
HOVERGENiHBG057668
InParanoidiQ9CXF4
KOiK20168
OMAiFKGGLCH
OrthoDBiEOG091G04IX
PhylomeDBiQ9CXF4
TreeFamiTF314296

Enzyme and pathway databases

ReactomeiR-MMU-8854214 TBC/RABGAPs

Miscellaneous databases

ChiTaRSiTbc1d15 mouse
PROiPR:Q9CXF4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020130 Expressed in 292 organ(s), highest expression level in secondary oocyte
CleanExiMM_TBC1D15
GenevisibleiQ9CXF4 MM

Family and domain databases

InterProiView protein in InterPro
IPR021935 DUF3548
IPR000195 Rab-GTPase-TBC_dom
IPR035969 Rab-GTPase_TBC_sf
PfamiView protein in Pfam
PF12068 DUF3548, 1 hit
PF00566 RabGAP-TBC, 1 hit
SMARTiView protein in SMART
SM00164 TBC, 1 hit
SUPFAMiSSF47923 SSF47923, 2 hits
PROSITEiView protein in PROSITE
PS50086 TBC_RABGAP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTBC15_MOUSE
AccessioniPrimary (citable) accession number: Q9CXF4
Secondary accession number(s): Q3UI41
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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