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Protein

B-cell CLL/lymphoma 7 protein family member A

Gene

Bcl7a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
B-cell CLL/lymphoma 7 protein family member A
Gene namesi
Name:Bcl7a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1924295 Bcl7a

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002398241 – 210B-cell CLL/lymphoma 7 protein family member AAdd BLAST210

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki199Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei203PhosphoserineBy similarity1
Modified residuei207PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9CXE2
PaxDbiQ9CXE2
PeptideAtlasiQ9CXE2
PRIDEiQ9CXE2

PTM databases

iPTMnetiQ9CXE2
PhosphoSitePlusiQ9CXE2

Expressioni

Gene expression databases

BgeeiENSMUSG00000029438 Expressed in 251 organ(s), highest expression level in manus
CleanExiMM_BCL7A
GenevisibleiQ9CXE2 MM

Interactioni

Protein-protein interaction databases

BioGridi218481, 3 interactors
ComplexPortaliCPX-1251 Embryonic stem cell-specific SWI/SNF ATP-dependent chromatin remodeling complex
STRINGi10090.ENSMUSP00000031391

Structurei

3D structure databases

ProteinModelPortaliQ9CXE2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BCL7 family.Curated

Phylogenomic databases

eggNOGiKOG4095 Eukaryota
ENOG4111TES LUCA
GeneTreeiENSGT00390000002172
HOGENOMiHOG000232196
HOVERGENiHBG008481
InParanoidiQ9CXE2
OMAiTISQVPR
OrthoDBiEOG091G0T7O
PhylomeDBiQ9CXE2
TreeFamiTF317441

Family and domain databases

InterProiView protein in InterPro
IPR006804 BCL7
PANTHERiPTHR12767 PTHR12767, 1 hit
PfamiView protein in Pfam
PF04714 BCL_N, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9CXE2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGRSVRAET RSRAKDDIKR VMAAIEKVRK WEKKWVTVGD TSLRIYKWVP
60 70 80 90 100
VTEPKVDDKN KNKKKGKDEK CGSEVTTPEN SSSPGMMDMH DDNSNQSSIA
110 120 130 140 150
DASPIKQENS SNSSPAPETN PPVPSDGTEA KADEAQADGK EHPGAEDASE
160 170 180 190 200
EQNSQSSMEN SVNSSEKAER QPSAESGLAA ETSAVSQDLE GVPPSKKMKL
210
EASQQNSEEM
Length:210
Mass (Da):22,781
Last modified:June 1, 2001 - v1
Checksum:i9AEB5745EE0E42F7
GO
Isoform 2 (identifier: Q9CXE2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     91-112: DDNSNQSSIADASPIKQENSSN → GEPRPSRSPCLGLSCVFVSLTG
     113-210: Missing.

Note: May be due to an intron retention.
Show »
Length:112
Mass (Da):12,554
Checksum:iD39A296E6B5A4BFB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti108E → V in BAC32088 (PubMed:16141072).Curated1
Sequence conflicti170R → L in BAC39745 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01927291 – 112DDNSN…ENSSN → GEPRPSRSPCLGLSCVFVSL TG in isoform 2. 2 PublicationsAdd BLAST22
Alternative sequenceiVSP_019273113 – 210Missing in isoform 2. 2 PublicationsAdd BLAST98

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014498 mRNA Translation: BAB29397.1
AK044782 mRNA Translation: BAC32088.1
AK086803 mRNA Translation: BAC39745.1
AK157720 mRNA Translation: BAE34167.1
BC017640 mRNA Translation: AAH17640.1
BC038481 mRNA Translation: AAH38481.1
BC046777 mRNA Translation: AAH46777.1
CCDSiCCDS19661.1 [Q9CXE2-1]
RefSeqiNP_084126.1, NM_029850.3 [Q9CXE2-1]
UniGeneiMm.151960

Genome annotation databases

EnsembliENSMUST00000031391; ENSMUSP00000031391; ENSMUSG00000029438 [Q9CXE2-1]
ENSMUST00000117971; ENSMUSP00000113264; ENSMUSG00000029438 [Q9CXE2-2]
GeneIDi77045
KEGGimmu:77045
UCSCiuc008znn.2 mouse [Q9CXE2-2]
uc008zno.2 mouse [Q9CXE2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014498 mRNA Translation: BAB29397.1
AK044782 mRNA Translation: BAC32088.1
AK086803 mRNA Translation: BAC39745.1
AK157720 mRNA Translation: BAE34167.1
BC017640 mRNA Translation: AAH17640.1
BC038481 mRNA Translation: AAH38481.1
BC046777 mRNA Translation: AAH46777.1
CCDSiCCDS19661.1 [Q9CXE2-1]
RefSeqiNP_084126.1, NM_029850.3 [Q9CXE2-1]
UniGeneiMm.151960

3D structure databases

ProteinModelPortaliQ9CXE2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi218481, 3 interactors
ComplexPortaliCPX-1251 Embryonic stem cell-specific SWI/SNF ATP-dependent chromatin remodeling complex
STRINGi10090.ENSMUSP00000031391

PTM databases

iPTMnetiQ9CXE2
PhosphoSitePlusiQ9CXE2

Proteomic databases

EPDiQ9CXE2
PaxDbiQ9CXE2
PeptideAtlasiQ9CXE2
PRIDEiQ9CXE2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031391; ENSMUSP00000031391; ENSMUSG00000029438 [Q9CXE2-1]
ENSMUST00000117971; ENSMUSP00000113264; ENSMUSG00000029438 [Q9CXE2-2]
GeneIDi77045
KEGGimmu:77045
UCSCiuc008znn.2 mouse [Q9CXE2-2]
uc008zno.2 mouse [Q9CXE2-1]

Organism-specific databases

CTDi605
MGIiMGI:1924295 Bcl7a

Phylogenomic databases

eggNOGiKOG4095 Eukaryota
ENOG4111TES LUCA
GeneTreeiENSGT00390000002172
HOGENOMiHOG000232196
HOVERGENiHBG008481
InParanoidiQ9CXE2
OMAiTISQVPR
OrthoDBiEOG091G0T7O
PhylomeDBiQ9CXE2
TreeFamiTF317441

Miscellaneous databases

ChiTaRSiBcl7a mouse
PROiPR:Q9CXE2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029438 Expressed in 251 organ(s), highest expression level in manus
CleanExiMM_BCL7A
GenevisibleiQ9CXE2 MM

Family and domain databases

InterProiView protein in InterPro
IPR006804 BCL7
PANTHERiPTHR12767 PTHR12767, 1 hit
PfamiView protein in Pfam
PF04714 BCL_N, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBCL7A_MOUSE
AccessioniPrimary (citable) accession number: Q9CXE2
Secondary accession number(s): Q8C361, Q8C8M8, Q8VD15
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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