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Protein

Leucine-rich repeat-containing protein 17

Gene

Lrrc17

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in bone homeostasis. Acts as a negative regulator of RANKL-induced osteoclast precursor differentiation from bone marrow precursors.1 Publication

GO - Biological processi

Keywordsi

Biological processOsteogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 17
Gene namesi
Name:Lrrc17
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1921761 Lrrc17

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Sequence analysisAdd BLAST15
ChainiPRO_000002160916 – 443Leucine-rich repeat-containing protein 17Add BLAST428

Proteomic databases

MaxQBiQ9CXD9
PaxDbiQ9CXD9
PRIDEiQ9CXD9

PTM databases

PhosphoSitePlusiQ9CXD9

Expressioni

Tissue specificityi

Expressed in osteoblasts, spleen, lung and heart.1 Publication

Inductioni

Down-regulated in osteoblasts in response to pro-osteoclastogenic factors.1 Publication

Gene expression databases

BgeeiENSMUSG00000039883 Expressed in 155 organ(s), highest expression level in humerus cartilage element
CleanExiMM_LRRC17
GenevisibleiQ9CXD9 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038569

Structurei

3D structure databases

ProteinModelPortaliQ9CXD9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati84 – 105LRR 1Add BLAST22
Repeati108 – 129LRR 2Add BLAST22
Repeati132 – 153LRR 3Add BLAST22
Domaini165 – 216LRRCT 1Add BLAST52
Domaini229 – 270LRRNTAdd BLAST42
Repeati271 – 292LRR 4Add BLAST22
Repeati295 – 316LRR 5Add BLAST22
Repeati319 – 342LRR 6Add BLAST24
Domaini352 – 404LRRCT 2Add BLAST53

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00930000150809
HOGENOMiHOG000113365
HOVERGENiHBG052344
InParanoidiQ9CXD9
OMAiEEYKGWF
OrthoDBiEOG091G06KH
PhylomeDBiQ9CXD9

Family and domain databases

Gene3Di3.80.10.10, 3 hits
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF13855 LRR_8, 2 hits
SMARTiView protein in SMART
SM00369 LRR_TYP, 5 hits
SM00082 LRRCT, 2 hits
PROSITEiView protein in PROSITE
PS51450 LRR, 6 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CXD9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRIVAILLLF CLCRAAEPRK SSPGVLRSQG NPSRSHGRGG RRGSSPVKRY
60 70 80 90 100
APGLPCDVYT YLHEKYLDCQ ERKLVYVLPD WPQDLLHMLL ARNKIRVLKN
110 120 130 140 150
NMFAKFKRLK SLDLQQNEIS KIESEAFFGL NKLTTLLLQH NQIKVLTEEA
160 170 180 190 200
FIYTPLLSYL RLYDNPWHCT CELETLISML QIPRNRNLGN YAKCGSPPAL
210 220 230 240 250
RNKKLLQLKP QELCDEEEKE QLDPKPQVSG IPAVIRPEAD STLCHNYVFP
260 270 280 290 300
IQTLDCKRKE LKKVPSNIPP DIVKLDLSSN KIRQLRPKEF EDVHELKKLN
310 320 330 340 350
LSSNGIEFID PAAFLGLIHL EELDLSNNSL QNFDYGVLED LYFLKLLWLR
360 370 380 390 400
DNPWRCDYSI HYLYYWLKHH YNVHYNGLEC KTPEEYKGWS VGKYVRSYYE
410 420 430 440
ECPKDKLPAY PETFDQDTED DEWQKIHRDH PAKKHRVRIT IVG
Length:443
Mass (Da):51,852
Last modified:June 1, 2001 - v1
Checksum:iCF5C962262BB555E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018071 mRNA Translation: BAB31060.1
BC030317 mRNA Translation: AAH30317.1
CCDSiCCDS51428.1
RefSeqiNP_083253.1, NM_028977.1
UniGeneiMm.439963

Genome annotation databases

EnsembliENSMUST00000035651; ENSMUSP00000038569; ENSMUSG00000039883
GeneIDi74511
KEGGimmu:74511
UCSCiuc008wor.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018071 mRNA Translation: BAB31060.1
BC030317 mRNA Translation: AAH30317.1
CCDSiCCDS51428.1
RefSeqiNP_083253.1, NM_028977.1
UniGeneiMm.439963

3D structure databases

ProteinModelPortaliQ9CXD9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038569

PTM databases

PhosphoSitePlusiQ9CXD9

Proteomic databases

MaxQBiQ9CXD9
PaxDbiQ9CXD9
PRIDEiQ9CXD9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035651; ENSMUSP00000038569; ENSMUSG00000039883
GeneIDi74511
KEGGimmu:74511
UCSCiuc008wor.2 mouse

Organism-specific databases

CTDi10234
MGIiMGI:1921761 Lrrc17

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00930000150809
HOGENOMiHOG000113365
HOVERGENiHBG052344
InParanoidiQ9CXD9
OMAiEEYKGWF
OrthoDBiEOG091G06KH
PhylomeDBiQ9CXD9

Miscellaneous databases

PROiPR:Q9CXD9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039883 Expressed in 155 organ(s), highest expression level in humerus cartilage element
CleanExiMM_LRRC17
GenevisibleiQ9CXD9 MM

Family and domain databases

Gene3Di3.80.10.10, 3 hits
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF13855 LRR_8, 2 hits
SMARTiView protein in SMART
SM00369 LRR_TYP, 5 hits
SM00082 LRRCT, 2 hits
PROSITEiView protein in PROSITE
PS51450 LRR, 6 hits
ProtoNetiSearch...

Entry informationi

Entry nameiLRC17_MOUSE
AccessioniPrimary (citable) accession number: Q9CXD9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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