UniProtKB - Q9CXD6 (MCUR1_MOUSE)
Protein
Mitochondrial calcium uniporter regulator 1
Gene
Mcur1
Organism
Mus musculus (Mouse)
Status
Functioni
Key regulator of mitochondrial calcium uniporter (MCU) required for calcium entry into mitochondrion. Plays a direct role in uniporter-mediated calcium uptake via a direct interaction with MCU. Probably involved in the assembly of the membrane components of the uniporter complex (uniplex).By similarity
GO - Biological processi
- calcium import into the mitochondrion Source: UniProtKB
- calcium ion import Source: UniProtKB
- mitochondrial calcium ion transmembrane transport Source: UniProtKB
- positive regulation of mitochondrial calcium ion concentration Source: UniProtKB
Keywordsi
Biological process | Calcium transport, Ion transport, Transport |
Ligand | Calcium |
Names & Taxonomyi
Protein namesi | Recommended name: Mitochondrial calcium uniporter regulator 1By similarityShort name: MCU regulator 1By similarity Alternative name(s): Coiled-coil domain-containing protein 90A, mitochondrialCurated |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1923387, Mcur1 |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane By similarity; Multi-pass membrane protein By similarity
Mitochondrion
- integral component of mitochondrial inner membrane Source: UniProtKB
- mitochondrion Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 54 | Mitochondrial intermembraneBy similarityAdd BLAST | 54 | |
Transmembranei | 55 – 74 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 75 – 316 | Mitochondrial matrixBy similarityAdd BLAST | 242 | |
Transmembranei | 317 – 339 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 340 | Mitochondrial intermembraneBy similarity | 1 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePathology & Biotechi
Disruption phenotypei
Conditional knockout mice lacking Mcur1 in cardiomyocytes and endothelial cells are viable and are born at the expected Mendelian. They however show impaired mitochondrial calcium uptake and mitochondrial calcium uniporter (MCU) current.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000295693 | 1 – 340 | Mitochondrial calcium uniporter regulator 1Add BLAST | 340 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 204 | N6-acetyllysineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q9CXD6 |
jPOSTi | Q9CXD6 |
PaxDbi | Q9CXD6 |
PeptideAtlasi | Q9CXD6 |
PRIDEi | Q9CXD6 |
PTM databases
iPTMneti | Q9CXD6 |
PhosphoSitePlusi | Q9CXD6 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000021371, Expressed in adult mammalian kidney and 256 other tissues |
Genevisiblei | Q9CXD6, MM |
Interactioni
Subunit structurei
Interacts (via coiled coil regions) with MCU; the interaction is direct.
Interacts with SMDT1/EMRE; the interaction is direct.
Interacts with PPIF.
By similarityProtein-protein interaction databases
STRINGi | 10090.ENSMUSP00000021800 |
Miscellaneous databases
RNActi | Q9CXD6, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 197 – 291 | Sequence analysisAdd BLAST | 95 |
Sequence similaritiesi
Belongs to the CCDC90 family.Curated
Keywords - Domaini
Coiled coil, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3156, Eukaryota |
GeneTreei | ENSGT00940000158957 |
HOGENOMi | CLU_791208_0_0_1 |
InParanoidi | Q9CXD6 |
OMAi | MSHITAV |
OrthoDBi | 1252164at2759 |
PhylomeDBi | Q9CXD6 |
TreeFami | TF331442 |
Family and domain databases
InterProi | View protein in InterPro IPR024461, DUF1640 IPR012439, MCUR1 |
PANTHERi | PTHR14360, PTHR14360, 1 hit PTHR14360:SF11, PTHR14360:SF11, 1 hit |
Pfami | View protein in Pfam PF07798, DUF1640, 1 hit |
s (3)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q9CXD6-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDSGSVAAER PRRTPSRQRL PSSGCGVPAR PGVSTLPGGR SWLRPRGRAA
60 70 80 90 100
RASPLLFLLL VPSPRLAATA TATAPRRTLA ERSRPGLVLP AAALGAGRNA
110 120 130 140 150
LGRLRLGARR VAALASSRRE LSLSAKCHQL EHRKENLPLS VSRQLYFDTH
160 170 180 190 200
ALVCLLEANG FTIQQAEIIV SALVKITETN MNIIYKDMVS KMQQEIALQQ
210 220 230 240 250
VLSKIANVKK DMVILEKSEF SALRAENEKI KLELHQLKQQ VMDEVTKVRT
260 270 280 290 300
DTKLNFNLEK SRVKELYSLN EKKMLELRTE IVSLHAQQDR ALTQTDRKIE
310 320 330 340
TEVAGLKTML EAHKLDTIKY LAGSVFTCLT VALGFYRLWI
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 52 | A → G in BAE20607 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_027000 | 1 – 180 | Missing in isoform 3. 1 PublicationAdd BLAST | 180 | |
Alternative sequenceiVSP_027001 | 267 – 286 | YSLNE…VSLHA → VCSFIKSKSLIYFFLDWNAC in isoform 2. 1 PublicationAdd BLAST | 20 | |
Alternative sequenceiVSP_027002 | 287 – 340 | Missing in isoform 2. 1 PublicationAdd BLAST | 54 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK018089 mRNA Translation: BAB31065.1 AK041849 mRNA Translation: BAE20607.1 BC113195 mRNA Translation: AAI13196.1 |
CCDSi | CCDS36645.1 [Q9CXD6-1] |
RefSeqi | NP_001074528.1, NM_001081059.3 [Q9CXD6-1] |
Genome annotation databases
Ensembli | ENSMUST00000021800; ENSMUSP00000021800; ENSMUSG00000021371 [Q9CXD6-1] |
GeneIDi | 76137 |
KEGGi | mmu:76137 |
UCSCi | uc007qgf.2, mouse [Q9CXD6-1] uc007qgg.2, mouse [Q9CXD6-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK018089 mRNA Translation: BAB31065.1 AK041849 mRNA Translation: BAE20607.1 BC113195 mRNA Translation: AAI13196.1 |
CCDSi | CCDS36645.1 [Q9CXD6-1] |
RefSeqi | NP_001074528.1, NM_001081059.3 [Q9CXD6-1] |
3D structure databases
SMRi | Q9CXD6 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000021800 |
PTM databases
iPTMneti | Q9CXD6 |
PhosphoSitePlusi | Q9CXD6 |
Proteomic databases
EPDi | Q9CXD6 |
jPOSTi | Q9CXD6 |
PaxDbi | Q9CXD6 |
PeptideAtlasi | Q9CXD6 |
PRIDEi | Q9CXD6 |
Protocols and materials databases
Antibodypediai | 25007, 74 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000021800; ENSMUSP00000021800; ENSMUSG00000021371 [Q9CXD6-1] |
GeneIDi | 76137 |
KEGGi | mmu:76137 |
UCSCi | uc007qgf.2, mouse [Q9CXD6-1] uc007qgg.2, mouse [Q9CXD6-2] |
Organism-specific databases
CTDi | 63933 |
MGIi | MGI:1923387, Mcur1 |
Phylogenomic databases
eggNOGi | KOG3156, Eukaryota |
GeneTreei | ENSGT00940000158957 |
HOGENOMi | CLU_791208_0_0_1 |
InParanoidi | Q9CXD6 |
OMAi | MSHITAV |
OrthoDBi | 1252164at2759 |
PhylomeDBi | Q9CXD6 |
TreeFami | TF331442 |
Miscellaneous databases
BioGRID-ORCSi | 76137, 0 hits in 17 CRISPR screens |
ChiTaRSi | Mcur1, mouse |
PROi | PR:Q9CXD6 |
RNActi | Q9CXD6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000021371, Expressed in adult mammalian kidney and 256 other tissues |
Genevisiblei | Q9CXD6, MM |
Family and domain databases
InterProi | View protein in InterPro IPR024461, DUF1640 IPR012439, MCUR1 |
PANTHERi | PTHR14360, PTHR14360, 1 hit PTHR14360:SF11, PTHR14360:SF11, 1 hit |
Pfami | View protein in Pfam PF07798, DUF1640, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MCUR1_MOUSE | |
Accessioni | Q9CXD6Primary (citable) accession number: Q9CXD6 Secondary accession number(s): Q14DH8, Q3V3D3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 24, 2007 |
Last sequence update: | June 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 120 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families