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Protein

ETS translocation variant 5

Gene

Etv5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds to DNA sequences containing the consensus nucleotide core sequence 5'-GGAA.-3'.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi368 – 448ETSPROSITE-ProRule annotationAdd BLAST81

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ETS translocation variant 5
Gene namesi
Name:Etv5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1096867 Etv5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002041191 – 510ETS translocation variant 5Add BLAST510

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei248PhosphoserineBy similarity1
Cross-linki350Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ9CXC9
PRIDEiQ9CXC9

PTM databases

iPTMnetiQ9CXC9
PhosphoSitePlusiQ9CXC9

Expressioni

Tissue specificityi

In the brain, expressed predominantly in the cerebral cortex, the amygdala and the hypothalamus. Within the cerebral cortex, there is conspicuously high expression in cortical layers 2, 4 and 6 while expression is almost absent from layers 1, 3 and 5. High expression is also observed in the dorsal and ventral endopiriform claustrum. Strong expression is observed in limited parts of the amygdala including the basolateral amygdaloid nucleus, the bed stria terminalis and the central amygdaloid nucleus. Low to moderate levels are found in the hypothalamus while expression is almost absent in the thalamus. Hypothalamic expression is seen in the dorsomedial hypothalamic nucleus and also the central, dorsomedial and ventrolateral parts of the ventromedial hypothalamic nucleus. Strong expression is also identified in the nigrostriatal tract. In the mesencephalon, expression is restricted to the ventral tegmental area including the parabrachial pigmented nucleus. In the hippocampus, strongly expressed in the pyramidal cell layer. Some expression is also found in the lacunosum moleculare layer. Low levels of expression in the cerebellum, including the granular, molecular and Purkinje cell layers.1 Publication

Gene expression databases

BgeeiENSMUSG00000013089 Expressed in 342 organ(s), highest expression level in left lung lobe
CleanExiMM_ETV5
ExpressionAtlasiQ9CXC9 baseline and differential
GenevisibleiQ9CXC9 MM

Interactioni

Subunit structurei

Interacts (via C-terminal) with ZMYM5 (via N-terminal 120 amino acid region).By similarity

Protein-protein interaction databases

BioGridi222408, 1 interactor
DIPiDIP-60467N
IntActiQ9CXC9, 1 interactor
STRINGi10090.ENSMUSP00000078551

Structurei

3D structure databases

ProteinModelPortaliQ9CXC9
SMRiQ9CXC9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ETS family.Curated

Phylogenomic databases

eggNOGiKOG3806 Eukaryota
ENOG410Z0ZF LUCA
GeneTreeiENSGT00760000118907
HOGENOMiHOG000230986
HOVERGENiHBG000231
InParanoidiQ9CXC9
KOiK15593
TreeFamiTF316214

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000418 Ets_dom
IPR006715 ETS_PEA3_N
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00178 Ets, 1 hit
PF04621 ETS_PEA3_N, 1 hit
PRINTSiPR00454 ETSDOMAIN
SMARTiView protein in SMART
SM00413 ETS, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00345 ETS_DOMAIN_1, 1 hit
PS00346 ETS_DOMAIN_2, 1 hit
PS50061 ETS_DOMAIN_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.iShow all

Q9CXC9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDGFCDQQVP FMVPGKSRSE DCRGRPLIDR KRKFVDTDLA HDSEELFQDL
60 70 80 90 100
SQLQEAWLAE AQVPDDEQFV PDFQSDNLVL HAPPPTKIKR ELHSPSSELS
110 120 130 140 150
SCSHEQALGA KYGEKCLYNY CAYDRKPPSG FKPLTPPATP LSPTHQNSLF
160 170 180 190 200
PPPQATLPTS GLTPGAGPVQ GVGPAPTPHS LPEPGSQQQT FAVPRPPHQP
210 220 230 240 250
LQMPKMMPES QYPSEQRFQR QLSEPSHPFP PQSGVPGDSR PSYHRQMSEP
260 270 280 290 300
IVPAAPPPLQ GFKQEYHDPL YEHGVPGMPG PPAHGFQSPM GIKQEPRDYC
310 320 330 340 350
ADSEVPNCQS SYMRGGYFSS SHEGFPYEKD PRLYFDDTCV VPERLEGKVK
360 370 380 390 400
QEPTMYREGP PYQRRGSLQL WQFLVTLLDD PANAHFIAWT GRGMEFKLIE
410 420 430 440 450
PEEVARRWGI QKNRPAMNYD KLSRSLRYYY EKGIMQKVAG ERYVYKFVCD
460 470 480 490 500
PDALFSMAFP DNQRPFLKAE SECPLNEEDT LPLTHFEDNP AYLLDMDRCS
510
SLPYTEGFAY
Length:510
Mass (Da):57,712
Last modified:June 1, 2001 - v1
Checksum:i371560F7E84A8F74
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8BJR1Q8BJR1_MOUSE
ETS translocation variant 5
Etv5
528Annotation score:
F6Q487F6Q487_MOUSE
ETS translocation variant 5
Etv5
89Annotation score:
E9Q288E9Q288_MOUSE
ETS translocation variant 5
Etv5
94Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti271Y → F in AAF85761 (PubMed:9285689).Curated1
Sequence conflicti283A → V in AAF85761 (PubMed:9285689).Curated1
Sequence conflicti396F → I in BAC27412 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY004174 mRNA Translation: AAF85761.1
AK018368 mRNA Translation: BAB31180.1
AK031452 mRNA Translation: BAC27412.1
AK168881 mRNA Translation: BAE40699.1
BC034680 mRNA Translation: AAH34680.1
CCDSiCCDS37299.1
RefSeqiNP_076283.2, NM_023794.2
XP_006521720.1, XM_006521657.3
UniGeneiMm.155708

Genome annotation databases

EnsembliENSMUST00000079601; ENSMUSP00000078551; ENSMUSG00000013089
GeneIDi104156
KEGGimmu:104156
UCSCiuc007yse.1 mouse

Similar proteinsi

Entry informationi

Entry nameiETV5_MOUSE
AccessioniPrimary (citable) accession number: Q9CXC9
Secondary accession number(s): Q3TG49, Q8C0F3, Q9JHB1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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