UniProtKB - Q9CXB2 (SOAT_MOUSE)
Protein
Solute carrier family 10 member 6
Gene
Slc10a6
Organism
Mus musculus (Mouse)
Status
Functioni
Transports sulfoconjugated steroid hormones, as well as taurolithocholic acid-3-sulfate and sulfoconjugated pyrenes in a sodium-dependent manner.By similarity
GO - Molecular functioni
- bile acid:sodium symporter activity Source: GO_Central
- sodium-dependent organic anion transmembrane transporter activity Source: MGI
GO - Biological processi
- bile acid and bile salt transport Source: GO_Central
- sodium-dependent organic anion transport Source: MGI
Keywordsi
Biological process | Ion transport, Sodium transport, Symport, Transport |
Ligand | Sodium |
Enzyme and pathway databases
Reactomei | R-MMU-425366, Transport of bile salts and organic acids, metal ions and amine compounds |
Names & Taxonomyi
Protein namesi | Recommended name: Solute carrier family 10 member 6Alternative name(s): Sodium-dependent organic anion transporter |
Gene namesi | Name:Slc10a6 Synonyms:Soat |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1923000, Slc10a6 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Plasma Membrane
- plasma membrane Source: InterPro
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 32 | ExtracellularSequence analysisAdd BLAST | 32 | |
Transmembranei | 33 – 53 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 54 – 67 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 68 – 88 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 89 – 97 | ExtracellularSequence analysis | 9 | |
Transmembranei | 98 – 118 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 119 – 126 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 127 – 147 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 148 – 157 | ExtracellularSequence analysis | 10 | |
Transmembranei | 158 – 178 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 179 – 195 | CytoplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 196 – 216 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 217 – 224 | ExtracellularSequence analysis | 8 | |
Transmembranei | 225 – 245 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 246 – 265 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 266 – 283 | HelicalSequence analysisAdd BLAST | 18 | |
Topological domaini | 284 | ExtracellularSequence analysis | 1 | |
Transmembranei | 285 – 305 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 306 – 373 | CytoplasmicSequence analysisAdd BLAST | 68 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000309216 | 1 – 373 | Solute carrier family 10 member 6Add BLAST | 373 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 8 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 14 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Glycosylated.By similarity
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | Q9CXB2 |
PRIDEi | Q9CXB2 |
PTM databases
GlyGeni | Q9CXB2, 2 sites |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000029321, Expressed in embryo and 140 other tissues |
Genevisiblei | Q9CXB2, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000031263 |
Miscellaneous databases
RNActi | Q9CXB2, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2718, Eukaryota |
GeneTreei | ENSGT00950000182808 |
HOGENOMi | CLU_034788_7_5_1 |
InParanoidi | Q9CXB2 |
OMAi | MEIGIHN |
OrthoDBi | 1148347at2759 |
PhylomeDBi | Q9CXB2 |
TreeFami | TF315811 |
Family and domain databases
Gene3Di | 1.20.1530.20, 1 hit |
InterProi | View protein in InterPro IPR002657, BilAc:Na_symport/Acr3 IPR004710, Bilac:Na_transpt IPR038770, Na+/solute_symporter_sf IPR030203, SLC10A6 |
PANTHERi | PTHR10361, PTHR10361, 1 hit PTHR10361:SF55, PTHR10361:SF55, 1 hit |
Pfami | View protein in Pfam PF01758, SBF, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9CXB2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSTDCAGNST CPVNSTEEDP PVGMEGHANL KLLFTVLSAV MVGLVMFSFG
60 70 80 90 100
CSVESQKLWL HLRRPWGIAV GLLSQFGLMP LTAYLLAIGF GLKPFQAIAV
110 120 130 140 150
LMMGSCPGGT ISNVLTFWVD GDMDLSISMT TCSTVAALGM MPLCLYIYTR
160 170 180 190 200
SWTLTQNLVI PYQSIGITLV SLVVPVASGV YVNYRWPKQA TVILKVGAIL
210 220 230 240 250
GGMLLLVVAV TGMVLAKGWN TDVTLLVISC IFPLVGHVTG FLLAFLTHQS
260 270 280 290 300
WQRCRTISIE TGAQNIQLCI AMLQLSFSAE YLVQLLNFAL AYGLFQVLHG
310 320 330 340 350
LLIVAAYQAY KRRQKSKCRR QHPDCPDVCY EKQPRETSAF LDKGDEAAVT
360 370
LGPVQPEQHH RAAELTSHIP SCE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ583504 mRNA Translation: CAE47479.1 AK018423 mRNA Translation: BAB31203.1 BC127608 mRNA Translation: AAI27609.1 BC139343 mRNA Translation: AAI39344.1 BC139346 mRNA Translation: AAI39347.1 |
CCDSi | CCDS19477.1 |
RefSeqi | NP_083691.1, NM_029415.2 |
Genome annotation databases
Ensembli | ENSMUST00000031263; ENSMUSP00000031263; ENSMUSG00000029321 |
GeneIDi | 75750 |
KEGGi | mmu:75750 |
UCSCi | uc008yjp.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ583504 mRNA Translation: CAE47479.1 AK018423 mRNA Translation: BAB31203.1 BC127608 mRNA Translation: AAI27609.1 BC139343 mRNA Translation: AAI39344.1 BC139346 mRNA Translation: AAI39347.1 |
CCDSi | CCDS19477.1 |
RefSeqi | NP_083691.1, NM_029415.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000031263 |
PTM databases
GlyGeni | Q9CXB2, 2 sites |
Proteomic databases
PaxDbi | Q9CXB2 |
PRIDEi | Q9CXB2 |
Protocols and materials databases
Antibodypediai | 14387, 41 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000031263; ENSMUSP00000031263; ENSMUSG00000029321 |
GeneIDi | 75750 |
KEGGi | mmu:75750 |
UCSCi | uc008yjp.1, mouse |
Organism-specific databases
CTDi | 345274 |
MGIi | MGI:1923000, Slc10a6 |
Phylogenomic databases
eggNOGi | KOG2718, Eukaryota |
GeneTreei | ENSGT00950000182808 |
HOGENOMi | CLU_034788_7_5_1 |
InParanoidi | Q9CXB2 |
OMAi | MEIGIHN |
OrthoDBi | 1148347at2759 |
PhylomeDBi | Q9CXB2 |
TreeFami | TF315811 |
Enzyme and pathway databases
Reactomei | R-MMU-425366, Transport of bile salts and organic acids, metal ions and amine compounds |
Miscellaneous databases
BioGRID-ORCSi | 75750, 1 hit in 17 CRISPR screens |
ChiTaRSi | Slc10a6, mouse |
PROi | PR:Q9CXB2 |
RNActi | Q9CXB2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000029321, Expressed in embryo and 140 other tissues |
Genevisiblei | Q9CXB2, MM |
Family and domain databases
Gene3Di | 1.20.1530.20, 1 hit |
InterProi | View protein in InterPro IPR002657, BilAc:Na_symport/Acr3 IPR004710, Bilac:Na_transpt IPR038770, Na+/solute_symporter_sf IPR030203, SLC10A6 |
PANTHERi | PTHR10361, PTHR10361, 1 hit PTHR10361:SF55, PTHR10361:SF55, 1 hit |
Pfami | View protein in Pfam PF01758, SBF, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SOAT_MOUSE | |
Accessioni | Q9CXB2Primary (citable) accession number: Q9CXB2 Secondary accession number(s): B2RTH4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 13, 2007 |
Last sequence update: | June 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 114 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families