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Protein

Trans-L-3-hydroxyproline dehydratase

Gene

L3hypdh

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the dehydration of trans-3-hydroxy-L-proline to delta-1-pyrroline-2-carboxylate (Pyr2C).1 Publication

Miscellaneous

In contrast to the T.cruzi proline racemase enzyme, lacks the conserved Cys at position 273 which is replaced by a Thr residue, transforming the racemase activity into dehydratase activity.By similarity

Catalytic activityi

Trans-3-hydroxy-L-proline = 1-pyrroline 2-carboxylate + H2O.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei104Proton acceptorBy similarity1
Binding sitei269SubstrateBy similarity1

GO - Molecular functioni

  • hydro-lyase activity Source: UniProtKB
  • trans-L-3-hydroxyproline dehydratase activity Source: UniProtKB-EC

Keywordsi

Molecular functionLyase

Names & Taxonomyi

Protein namesi
Recommended name:
Trans-L-3-hydroxyproline dehydratase (EC:4.2.1.77)
Alternative name(s):
Trans-3-hydroxy-L-proline dehydratase
Gene namesi
Name:L3hypdh
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1914467 L3hypdh

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002889501 – 354Trans-L-3-hydroxyproline dehydrataseAdd BLAST354

Proteomic databases

MaxQBiQ9CXA2
PaxDbiQ9CXA2
PeptideAtlasiQ9CXA2
PRIDEiQ9CXA2

PTM databases

iPTMnetiQ9CXA2
PhosphoSitePlusiQ9CXA2

Expressioni

Gene expression databases

BgeeiENSMUSG00000019718 Expressed in 193 organ(s), highest expression level in adult mammalian kidney
CleanExiMM_2810055F11RIK
GenevisibleiQ9CXA2 MM

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiQ9CXA2, 1 interactor
MINTiQ9CXA2
STRINGi10090.ENSMUSP00000019862

Structurei

3D structure databases

ProteinModelPortaliQ9CXA2
SMRiQ9CXA2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni105 – 106Substrate bindingBy similarity2
Regioni274 – 275Substrate bindingBy similarity2

Sequence similaritiesi

Belongs to the proline racemase family.Curated

Phylogenomic databases

eggNOGiENOG410IIC6 Eukaryota
COG3938 LUCA
GeneTreeiENSGT00390000002032
HOGENOMiHOG000084336
HOVERGENiHBG057443
InParanoidiQ9CXA2
KOiK18384
OMAiRHAMAIH
OrthoDBiEOG091G0CI6
PhylomeDBiQ9CXA2
TreeFamiTF329167

Family and domain databases

InterProiView protein in InterPro
IPR008794 Pro_racemase_fam
PANTHERiPTHR33442 PTHR33442, 1 hit
PfamiView protein in Pfam
PF05544 Pro_racemase, 1 hit
PIRSFiPIRSF029792 Pro_racemase, 1 hit
SFLDiSFLDS00028 Proline_Racemase, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CXA2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAALAVTRL PPNDPRTPAL SVVDMHTGGE PLRIVHAGCP EVAGPTLLAK
60 70 80 90 100
RRYMRQHLDY IRRRLVFEPR GHRDMYGAIL VPSELPDAHL GVLFLHNEGY
110 120 130 140 150
SSMCGHAVLA LGRFALDFGL VPAPPKGARE AQVNIHCPCG LVTAFVECEG
160 170 180 190 200
GRSCGPVRFH SVPAFVLASD LTVDVPGHGK VLVDIAYGGA FYAFVSAEKL
210 220 230 240 250
GLDVCSAKTR DLVDAASALT GAVKAQFKIN HPESEDLGFL YGSILTDGKD
260 270 280 290 300
AYSEEATTNI CVFADEQVDR SPTGSGVTAR IALQYHKGLL QLNQTRAFKS
310 320 330 340 350
SATGSVFTGC AVREAKCGDF KAVIVEVAGQ AHYTGTANLT VEDGDPLRDG

FLLK
Length:354
Mass (Da):37,804
Last modified:June 1, 2001 - v1
Checksum:iB993BF8E7BFA3505
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13N → H in AAH04753 (PubMed:15489334).Curated1
Sequence conflicti15P → S in AAH04753 (PubMed:15489334).Curated1
Sequence conflicti81V → M in AAH04753 (PubMed:15489334).Curated1
Sequence conflicti126K → E in AAH04753 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018449 mRNA Translation: BAB31217.1
CR974486 Genomic DNA No translation available.
BC004753 mRNA Translation: AAH04753.1
CCDSiCCDS25966.1
RefSeqiNP_080314.1, NM_026038.2
UniGeneiMm.286120

Genome annotation databases

EnsembliENSMUST00000019862; ENSMUSP00000019862; ENSMUSG00000019718
GeneIDi67217
KEGGimmu:67217
UCSCiuc007nvd.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018449 mRNA Translation: BAB31217.1
CR974486 Genomic DNA No translation available.
BC004753 mRNA Translation: AAH04753.1
CCDSiCCDS25966.1
RefSeqiNP_080314.1, NM_026038.2
UniGeneiMm.286120

3D structure databases

ProteinModelPortaliQ9CXA2
SMRiQ9CXA2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9CXA2, 1 interactor
MINTiQ9CXA2
STRINGi10090.ENSMUSP00000019862

PTM databases

iPTMnetiQ9CXA2
PhosphoSitePlusiQ9CXA2

Proteomic databases

MaxQBiQ9CXA2
PaxDbiQ9CXA2
PeptideAtlasiQ9CXA2
PRIDEiQ9CXA2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019862; ENSMUSP00000019862; ENSMUSG00000019718
GeneIDi67217
KEGGimmu:67217
UCSCiuc007nvd.1 mouse

Organism-specific databases

CTDi112849
MGIiMGI:1914467 L3hypdh

Phylogenomic databases

eggNOGiENOG410IIC6 Eukaryota
COG3938 LUCA
GeneTreeiENSGT00390000002032
HOGENOMiHOG000084336
HOVERGENiHBG057443
InParanoidiQ9CXA2
KOiK18384
OMAiRHAMAIH
OrthoDBiEOG091G0CI6
PhylomeDBiQ9CXA2
TreeFamiTF329167

Miscellaneous databases

PROiPR:Q9CXA2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000019718 Expressed in 193 organ(s), highest expression level in adult mammalian kidney
CleanExiMM_2810055F11RIK
GenevisibleiQ9CXA2 MM

Family and domain databases

InterProiView protein in InterPro
IPR008794 Pro_racemase_fam
PANTHERiPTHR33442 PTHR33442, 1 hit
PfamiView protein in Pfam
PF05544 Pro_racemase, 1 hit
PIRSFiPIRSF029792 Pro_racemase, 1 hit
SFLDiSFLDS00028 Proline_Racemase, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiT3HPD_MOUSE
AccessioniPrimary (citable) accession number: Q9CXA2
Secondary accession number(s): B8JJ82, Q99KB5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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