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Protein

GRB2-related adapter protein

Gene

Grap

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway.By similarity

Enzyme and pathway databases

ReactomeiR-MMU-1433557 Signaling by SCF-KIT

Names & Taxonomyi

Protein namesi
Recommended name:
GRB2-related adapter protein
Gene namesi
Name:Grap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1918770 Grap

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000882071 – 217GRB2-related adapter proteinAdd BLAST217

Proteomic databases

EPDiQ9CX99
MaxQBiQ9CX99
PaxDbiQ9CX99
PRIDEiQ9CX99

PTM databases

iPTMnetiQ9CX99
PhosphoSitePlusiQ9CX99

Expressioni

Gene expression databases

BgeeiENSMUSG00000004837 Expressed in 124 organ(s), highest expression level in mesenteric lymph node
CleanExiMM_GRAP
GenevisibleiQ9CX99 MM

Interactioni

Subunit structurei

Associates through its SH2 domain with ligand-activated receptors for stem cell factor (KIT) and erythropoietin (EPOR). Also forms a stable complex with the Bcr-Abl oncoprotein. GRAP is associated with the Ras guanine nucleotide exchange factor SOS1, primarily through its N-terminal SH3 domain. Interacts with phosphorylated LAT upon TCR activation. Interacts with SHB (By similarity).By similarity

Protein-protein interaction databases

IntActiQ9CX99, 4 interactors
STRINGi10090.ENSMUSP00000004959

Structurei

3D structure databases

ProteinModelPortaliQ9CX99
SMRiQ9CX99
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 58SH3 1PROSITE-ProRule annotationAdd BLAST58
Domaini60 – 152SH2PROSITE-ProRule annotationAdd BLAST93
Domaini158 – 217SH3 2PROSITE-ProRule annotationAdd BLAST60

Sequence similaritiesi

Belongs to the GRB2/sem-5/DRK family.Curated

Keywords - Domaini

Repeat, SH2 domain, SH3 domain

Phylogenomic databases

eggNOGiKOG3601 Eukaryota
ENOG410XR1G LUCA
GeneTreeiENSGT00820000126999
HOGENOMiHOG000251625
HOVERGENiHBG005404
InParanoidiQ9CX99
OMAiRACFAQA
OrthoDBiEOG091G0HWS
PhylomeDBiQ9CX99
TreeFamiTF354288

Family and domain databases

CDDicd11948 SH3_GRAP_N, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR035645 GRAP_N_SH3
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PF00018 SH3_1, 1 hit
PF07653 SH3_2, 1 hit
PRINTSiPR00401 SH2DOMAIN
PR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00326 SH3, 2 hits
SUPFAMiSSF50044 SSF50044, 2 hits
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit
PS50002 SH3, 2 hits

Sequencei

Sequence statusi: Complete.

Q9CX99-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESVALYSFQ ATESDELAFN KGDTLKILNM EDDQNWYKAE LRGAEGFVPK
60 70 80 90 100
NYIRVKPHPW YSGRISRQLA EETLMKRNHL GAFLIRESES SPGEFSVSVN
110 120 130 140 150
YGDQVQHFKV LREASGKYFL WEEKFNSLNE LVDFYRTTTI AKRRQIFLCD
160 170 180 190 200
EQPLIKPSRA CFAQAQFDFS AQDPSQLSLR RGDIVEVVER EDPHWWRGRA
210
GGRLGFFPRS YVQPVHL
Length:217
Mass (Da):25,277
Last modified:June 1, 2001 - v1
Checksum:i1AF124C3D2773DD2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018457 mRNA Translation: BAB31222.1
AK153888 mRNA Translation: BAE32235.1
AL596209 Genomic DNA No translation available.
BC120674 mRNA Translation: AAI20675.1
BC120676 mRNA Translation: AAI20677.1
CCDSiCCDS24817.1
RefSeqiNP_082093.1, NM_027817.3
UniGeneiMm.202760

Genome annotation databases

EnsembliENSMUST00000004959; ENSMUSP00000004959; ENSMUSG00000004837
GeneIDi71520
KEGGimmu:71520
UCSCiuc007jhz.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018457 mRNA Translation: BAB31222.1
AK153888 mRNA Translation: BAE32235.1
AL596209 Genomic DNA No translation available.
BC120674 mRNA Translation: AAI20675.1
BC120676 mRNA Translation: AAI20677.1
CCDSiCCDS24817.1
RefSeqiNP_082093.1, NM_027817.3
UniGeneiMm.202760

3D structure databases

ProteinModelPortaliQ9CX99
SMRiQ9CX99
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9CX99, 4 interactors
STRINGi10090.ENSMUSP00000004959

PTM databases

iPTMnetiQ9CX99
PhosphoSitePlusiQ9CX99

Proteomic databases

EPDiQ9CX99
MaxQBiQ9CX99
PaxDbiQ9CX99
PRIDEiQ9CX99

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000004959; ENSMUSP00000004959; ENSMUSG00000004837
GeneIDi71520
KEGGimmu:71520
UCSCiuc007jhz.1 mouse

Organism-specific databases

CTDi10750
MGIiMGI:1918770 Grap

Phylogenomic databases

eggNOGiKOG3601 Eukaryota
ENOG410XR1G LUCA
GeneTreeiENSGT00820000126999
HOGENOMiHOG000251625
HOVERGENiHBG005404
InParanoidiQ9CX99
OMAiRACFAQA
OrthoDBiEOG091G0HWS
PhylomeDBiQ9CX99
TreeFamiTF354288

Enzyme and pathway databases

ReactomeiR-MMU-1433557 Signaling by SCF-KIT

Miscellaneous databases

ChiTaRSiGrap mouse
PROiPR:Q9CX99
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000004837 Expressed in 124 organ(s), highest expression level in mesenteric lymph node
CleanExiMM_GRAP
GenevisibleiQ9CX99 MM

Family and domain databases

CDDicd11948 SH3_GRAP_N, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR035645 GRAP_N_SH3
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PF00018 SH3_1, 1 hit
PF07653 SH3_2, 1 hit
PRINTSiPR00401 SH2DOMAIN
PR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00326 SH3, 2 hits
SUPFAMiSSF50044 SSF50044, 2 hits
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit
PS50002 SH3, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiGRAP_MOUSE
AccessioniPrimary (citable) accession number: Q9CX99
Secondary accession number(s): Q0VBE3, Q3U545
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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