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Protein

WD repeat-containing protein 55

Gene

Wdr55

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis.1 Publication

GO - Biological processi

  • ribosomal large subunit biogenesis Source: GO_Central
  • rRNA processing Source: UniProtKB

Keywordsi

Biological processrRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 55
Gene namesi
Name:Wdr55
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1915186 Wdr55

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Death before implantation of the embryo.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002375991 – 388WD repeat-containing protein 55Add BLAST388

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei355PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9CX97
MaxQBiQ9CX97
PaxDbiQ9CX97
PeptideAtlasiQ9CX97
PRIDEiQ9CX97

PTM databases

iPTMnetiQ9CX97
PhosphoSitePlusiQ9CX97

Expressioni

Gene expression databases

BgeeiENSMUSG00000042660
CleanExiMM_WDR55
GenevisibleiQ9CX97 MM

Interactioni

Protein-protein interaction databases

IntActiQ9CX97, 2 interactors
MINTiQ9CX97
STRINGi10090.ENSMUSP00000039010

Structurei

3D structure databases

ProteinModelPortaliQ9CX97
SMRiQ9CX97
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati37 – 76WD 1Add BLAST40
Repeati83 – 122WD 2Add BLAST40
Repeati126 – 164WD 3Add BLAST39
Repeati167 – 206WD 4Add BLAST40
Repeati209 – 248WD 5Add BLAST40
Repeati251 – 290WD 6Add BLAST40
Repeati293 – 333WD 7Add BLAST41

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi381 – 388Poly-Asp8

Sequence similaritiesi

Belongs to the WD repeat WDR55 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG2444 Eukaryota
ENOG410ZHU5 LUCA
GeneTreeiENSGT00530000064256
HOGENOMiHOG000242496
HOVERGENiHBG054778
InParanoidiQ9CX97
OMAiQSEPYEE
OrthoDBiEOG091G0BYA
PhylomeDBiQ9CX97
TreeFamiTF315175

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR024977 Apc4_WD40_dom
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
IPR017422 WDR55
PfamiView protein in Pfam
PF12894 ANAPC4_WD40, 1 hit
PF00400 WD40, 1 hit
PIRSFiPIRSF038169 WD_repeat_p55, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 6 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CX97-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPTCEESPA EDSNNEEEDL DSTKAAPRIR DTPEDIVLEA PASGLAFHPT
60 70 80 90 100
RDLLAAGDVD GDVFVFAYSC QEGETKELWS SGHHLKSCRA VVFSEDGQKL
110 120 130 140 150
VTVSKDKAIH ILDVEQGQLE RRISKAHSAP INSVLLVDEN ALVTGDDTGG
160 170 180 190 200
IRLWDQRKEG PLMDMRQHEE YIADMALDPA KKLLLTASGD GCLGVFNIKR
210 220 230 240 250
RRFELLSEPQ SGDLTSVALM KYGKKVACGS SEGTIYLFNW NGFGATSDRF
260 270 280 290 300
ALRAESIDCI VPVTENLLCT GSTDGIIRAV NILPNRVVGT VGQHAGEPVE
310 320 330 340 350
ALALSHCGHF LASSGHDQRL KFWDMTQLRT VVVDDYRRRK KKGGPLRALS
360 370 380
SKAWSTDDFF AGLREDEEDA KAPEEVVRES DDDDDDSD
Length:388
Mass (Da):42,611
Last modified:March 1, 2003 - v2
Checksum:iED6B412A9B0DF369
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018469 mRNA Translation: BAB31225.2
AK075958 mRNA Translation: BAC36082.1
AK146093 mRNA Translation: BAE26896.1
CH466557 Genomic DNA Translation: EDK97176.1
BC131932 mRNA Translation: AAI31933.1
BC131934 mRNA Translation: AAI31935.1
CCDSiCCDS29162.1
RefSeqiNP_080740.2, NM_026464.2
UniGeneiMm.271719

Genome annotation databases

EnsembliENSMUST00000049323; ENSMUSP00000039010; ENSMUSG00000042660
GeneIDi67936
KEGGimmu:67936
UCSCiuc008eol.1 mouse

Similar proteinsi

Entry informationi

Entry nameiWDR55_MOUSE
AccessioniPrimary (citable) accession number: Q9CX97
Secondary accession number(s): A2RS10
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: March 1, 2003
Last modified: July 18, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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