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Protein

Protein SGT1 homolog

Gene

Sugt1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in ubiquitination and subsequent proteasomal degradation of target proteins.

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-844456 The NLRP3 inflammasome

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SGT1 homologBy similarity
Alternative name(s):
Suppressor of G2 allele of SKP1 homologBy similarity
Gene namesi
Name:Sugt1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1915205 Sugt1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001063332 – 336Protein SGT1 homologAdd BLAST335

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei236PhosphothreonineBy similarity1
Modified residuei252PhosphoserineBy similarity1
Modified residuei255PhosphothreonineBy similarity1
Cross-linki266Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki266Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei302PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated at Ser-252 and Ser-302, dephosphorylation promotes nuclear translocation, most likely due to disruption of the SUGT1-HSP90 complex.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9CX34
MaxQBiQ9CX34
PaxDbiQ9CX34
PeptideAtlasiQ9CX34
PRIDEiQ9CX34

2D gel databases

REPRODUCTION-2DPAGEiQ9CX34

PTM databases

iPTMnetiQ9CX34
PhosphoSitePlusiQ9CX34
SwissPalmiQ9CX34

Expressioni

Gene expression databases

BgeeiENSMUSG00000022024 Expressed in 294 organ(s), highest expression level in morula
GenevisibleiQ9CX34 MM

Interactioni

Subunit structurei

Probably associates with SCF (SKP1-CUL1-F-box protein) complex through interaction with SKP1. Interacts with S100A6. Interacts with HSP90 (By similarity).By similarity

Protein-protein interaction databases

BioGridi212563, 3 interactors
IntActiQ9CX34, 2 interactors
MINTiQ9CX34
STRINGi10090.ENSMUSP00000052942

Structurei

3D structure databases

ProteinModelPortaliQ9CX34
SMRiQ9CX34
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati11 – 44TPR 1Add BLAST34
Repeati45 – 78TPR 2Add BLAST34
Repeati79 – 112TPR 3Add BLAST34
Domaini140 – 229CSPROSITE-ProRule annotationAdd BLAST90
Domaini247 – 336SGSPROSITE-ProRule annotationAdd BLAST90

Domaini

The CS domain mediates interaction with HSP90.By similarity

Sequence similaritiesi

Belongs to the SGT1 family.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG0548 Eukaryota
KOG1309 Eukaryota
COG5091 LUCA
GeneTreeiENSGT00390000013700
HOGENOMiHOG000248210
HOVERGENiHBG055080
InParanoidiQ9CX34
KOiK12795
OMAiTKVEIKM
OrthoDBiEOG091G0QQH
PhylomeDBiQ9CX34
TreeFamiTF105979

Family and domain databases

Gene3Di1.25.40.10, 1 hit
2.60.40.790, 1 hit
InterProiView protein in InterPro
IPR007052 CS_dom
IPR008978 HSP20-like_chaperone
IPR007699 SGS_dom
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF04969 CS, 1 hit
PF05002 SGS, 1 hit
PF13181 TPR_8, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 2 hits
SUPFAMiSSF48452 SSF48452, 1 hit
SSF49764 SSF49764, 1 hit
PROSITEiView protein in PROSITE
PS51203 CS, 1 hit
PS51048 SGS, 1 hit
PS50005 TPR, 3 hits
PS50293 TPR_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CX34-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAAAGPAS SQRLFQSFSD ALIDGDPQAA LEELTKALEQ NPDDAQYYCQ
60 70 80 90 100
RAYCHILLGK YRDGIADVKK SLELNPNNCT ALLRKGICEY HEKDYASALE
110 120 130 140 150
TFAEGQKLDS TDTNFDTWIK RCQEIQNGSE SEVSASQRTQ SKIKYDWYQT
160 170 180 190 200
ESHVIITLMI KSVQKNDVRV GFSERELSAL VKIPAGEDYS LKLRLLHPII
210 220 230 240 250
PEQSTFKVLS TKIEIKMKKP EAVRWEKLEG QGDEPTPKQF TADVKNMYPS
260 270 280 290 300
SSHYTRNWDK LVGEIKEEEK NEKLEGDAAL NKLFQQIYSD GSDEVKRAMN
310 320 330
KSFMESGGTV LSTNWSDVGK RKVEINPPDD MEWKQY
Length:336
Mass (Da):38,159
Last modified:January 23, 2007 - v3
Checksum:i2A06CA65E9EB6289
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti20D → N in BAB25326 (PubMed:16141072).Curated1
Sequence conflicti113T → I in BAB25326 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007881 mRNA Translation: BAB25326.1
AK020433 mRNA Translation: BAB32098.1
AK045153 mRNA Translation: BAC32241.1
AK082328 mRNA Translation: BAC38466.1
AK141416 mRNA Translation: BAE24677.1
AK148838 mRNA Translation: BAE28673.1
BC009167 mRNA Translation: AAH09167.1
CCDSiCCDS36988.1
RefSeqiNP_080750.1, NM_026474.5
UniGeneiMm.18972

Genome annotation databases

EnsembliENSMUST00000054908; ENSMUSP00000052942; ENSMUSG00000022024
GeneIDi67955
KEGGimmu:67955
UCSCiuc007ute.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007881 mRNA Translation: BAB25326.1
AK020433 mRNA Translation: BAB32098.1
AK045153 mRNA Translation: BAC32241.1
AK082328 mRNA Translation: BAC38466.1
AK141416 mRNA Translation: BAE24677.1
AK148838 mRNA Translation: BAE28673.1
BC009167 mRNA Translation: AAH09167.1
CCDSiCCDS36988.1
RefSeqiNP_080750.1, NM_026474.5
UniGeneiMm.18972

3D structure databases

ProteinModelPortaliQ9CX34
SMRiQ9CX34
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212563, 3 interactors
IntActiQ9CX34, 2 interactors
MINTiQ9CX34
STRINGi10090.ENSMUSP00000052942

PTM databases

iPTMnetiQ9CX34
PhosphoSitePlusiQ9CX34
SwissPalmiQ9CX34

2D gel databases

REPRODUCTION-2DPAGEiQ9CX34

Proteomic databases

EPDiQ9CX34
MaxQBiQ9CX34
PaxDbiQ9CX34
PeptideAtlasiQ9CX34
PRIDEiQ9CX34

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000054908; ENSMUSP00000052942; ENSMUSG00000022024
GeneIDi67955
KEGGimmu:67955
UCSCiuc007ute.1 mouse

Organism-specific databases

CTDi10910
MGIiMGI:1915205 Sugt1

Phylogenomic databases

eggNOGiKOG0548 Eukaryota
KOG1309 Eukaryota
COG5091 LUCA
GeneTreeiENSGT00390000013700
HOGENOMiHOG000248210
HOVERGENiHBG055080
InParanoidiQ9CX34
KOiK12795
OMAiTKVEIKM
OrthoDBiEOG091G0QQH
PhylomeDBiQ9CX34
TreeFamiTF105979

Enzyme and pathway databases

ReactomeiR-MMU-844456 The NLRP3 inflammasome

Miscellaneous databases

PROiPR:Q9CX34
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022024 Expressed in 294 organ(s), highest expression level in morula
GenevisibleiQ9CX34 MM

Family and domain databases

Gene3Di1.25.40.10, 1 hit
2.60.40.790, 1 hit
InterProiView protein in InterPro
IPR007052 CS_dom
IPR008978 HSP20-like_chaperone
IPR007699 SGS_dom
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF04969 CS, 1 hit
PF05002 SGS, 1 hit
PF13181 TPR_8, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 2 hits
SUPFAMiSSF48452 SSF48452, 1 hit
SSF49764 SSF49764, 1 hit
PROSITEiView protein in PROSITE
PS51203 CS, 1 hit
PS51048 SGS, 1 hit
PS50005 TPR, 3 hits
PS50293 TPR_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSGT1_MOUSE
AccessioniPrimary (citable) accession number: Q9CX34
Secondary accession number(s): Q3UF88, Q9CRE7, Q9D8M6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 142 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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