Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein cornichon homolog 4

Gene

Cnih4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in G protein-coupled receptors (GPCRs) trafficking from the endoplasmic reticulum to the cell surface; it promotes the exit of GPCRs from the early secretory pathway, likely through interaction with the COPII machinery.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Protein cornichon homolog 4
Short name:
CNIH-4
Alternative name(s):
Cornichon family AMPA receptor auxiliary protein 4
Gene namesi
Name:Cnih4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1925828 Cnih4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei5 – 25HelicalSequence analysisAdd BLAST21
Transmembranei57 – 77HelicalSequence analysisAdd BLAST21
Transmembranei118 – 138HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001222311 – 139Protein cornichon homolog 4Add BLAST139

Proteomic databases

MaxQBiQ9CX13
PaxDbiQ9CX13
PeptideAtlasiQ9CX13
PRIDEiQ9CX13

Expressioni

Gene expression databases

BgeeiENSMUSG00000062169 Expressed in 271 organ(s), highest expression level in endothelial cell of lymphatic vessel
CleanExiMM_CNIH4
ExpressionAtlasiQ9CX13 baseline and differential
GenevisibleiQ9CX13 MM

Interactioni

Subunit structurei

Interacts with Sec23/24 complex components SEC24B and SEC24D (By similarity). Interacts with CCR5 (By similarity). Interacts with ADRB2 in the early secretory pathway (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi221056, 1 interactor
IntActiQ9CX13, 1 interactor
STRINGi10090.ENSMUSP00000115772

Family & Domainsi

Sequence similaritiesi

Belongs to the cornichon family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2729 Eukaryota
ENOG4111MWH LUCA
GeneTreeiENSGT00390000015751
HOGENOMiHOG000214661
HOVERGENiHBG003814
InParanoidiQ9CX13
KOiK20368
OMAiAWNIYRY
OrthoDBiEOG091G0U69
PhylomeDBiQ9CX13
TreeFamiTF300083

Family and domain databases

InterProiView protein in InterPro
IPR003377 Cornichon
PfamiView protein in Pfam
PF03311 Cornichon, 1 hit
SMARTiView protein in SMART
SM01398 Cornichon, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9CX13-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAVVFLFSL LDCCALIFLS VYFIITLSDL ECDYINARSC CSKLNKWVIP
60 70 80 90 100
ELVGHTIVTV LMLVSLHWFI FLLNLPVATW NIYRFIMVPS GNMGVFDPTE
110 120 130
IHNRGQLKSH MKEAMIKLGF YLLCFFMYLY SMILALIND
Length:139
Mass (Da):16,089
Last modified:June 1, 2001 - v1
Checksum:iCA76B250D08EC091
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YZJ3D3YZJ3_MOUSE
Protein cornichon homolog 4
Cnih4
92Annotation score:
A0A0A6YW87A0A0A6YW87_MOUSE
Cornichon homolog 4 (Drosophila), i...
Cnih4 mCG_19851
78Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK021301 mRNA Translation: BAB32366.1
AK144157 mRNA Translation: BAE25737.1
AK165179 mRNA Translation: BAE38062.1
AK166153 mRNA Translation: BAE38600.1
BC065395 mRNA Translation: AAH65395.1
CCDSiCCDS15582.1
RefSeqiNP_084407.1, NM_030131.3
UniGeneiMm.38229

Genome annotation databases

EnsembliENSMUST00000134115; ENSMUSP00000115772; ENSMUSG00000062169
GeneIDi98417
KEGGimmu:98417
UCSCiuc007dxe.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK021301 mRNA Translation: BAB32366.1
AK144157 mRNA Translation: BAE25737.1
AK165179 mRNA Translation: BAE38062.1
AK166153 mRNA Translation: BAE38600.1
BC065395 mRNA Translation: AAH65395.1
CCDSiCCDS15582.1
RefSeqiNP_084407.1, NM_030131.3
UniGeneiMm.38229

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi221056, 1 interactor
IntActiQ9CX13, 1 interactor
STRINGi10090.ENSMUSP00000115772

Proteomic databases

MaxQBiQ9CX13
PaxDbiQ9CX13
PeptideAtlasiQ9CX13
PRIDEiQ9CX13

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000134115; ENSMUSP00000115772; ENSMUSG00000062169
GeneIDi98417
KEGGimmu:98417
UCSCiuc007dxe.2 mouse

Organism-specific databases

CTDi29097
MGIiMGI:1925828 Cnih4

Phylogenomic databases

eggNOGiKOG2729 Eukaryota
ENOG4111MWH LUCA
GeneTreeiENSGT00390000015751
HOGENOMiHOG000214661
HOVERGENiHBG003814
InParanoidiQ9CX13
KOiK20368
OMAiAWNIYRY
OrthoDBiEOG091G0U69
PhylomeDBiQ9CX13
TreeFamiTF300083

Miscellaneous databases

PROiPR:Q9CX13
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000062169 Expressed in 271 organ(s), highest expression level in endothelial cell of lymphatic vessel
CleanExiMM_CNIH4
ExpressionAtlasiQ9CX13 baseline and differential
GenevisibleiQ9CX13 MM

Family and domain databases

InterProiView protein in InterPro
IPR003377 Cornichon
PfamiView protein in Pfam
PF03311 Cornichon, 1 hit
SMARTiView protein in SMART
SM01398 Cornichon, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCNIH4_MOUSE
AccessioniPrimary (citable) accession number: Q9CX13
Secondary accession number(s): Q3TNM6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again