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Protein

Gamma-soluble NSF attachment protein

Gene

Napg

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.By similarity

GO - Molecular functioni

  • soluble NSF attachment protein activity Source: GO_Central
  • syntaxin binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-204005 COPII-mediated vesicle transport
R-MMU-6807878 COPI-mediated anterograde transport
R-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-MMU-6811438 Intra-Golgi traffic
R-MMU-6811440 Retrograde transport at the Trans-Golgi-Network

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-soluble NSF attachment protein
Short name:
SNAP-gamma
Alternative name(s):
N-ethylmaleimide-sensitive factor attachment protein gamma
Gene namesi
Name:Napg
Synonyms:Snapg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:104561 Napg

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002190641 – 312Gamma-soluble NSF attachment proteinAdd BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei284PhosphoserineCombined sources1
Modified residuei287PhosphothreonineCombined sources1
Modified residuei308PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9CWZ7
MaxQBiQ9CWZ7
PaxDbiQ9CWZ7
PeptideAtlasiQ9CWZ7
PRIDEiQ9CWZ7

PTM databases

iPTMnetiQ9CWZ7
PhosphoSitePlusiQ9CWZ7
SwissPalmiQ9CWZ7

Expressioni

Gene expression databases

BgeeiENSMUSG00000024581 Expressed in 271 organ(s), highest expression level in Ammon's horn
ExpressionAtlasiQ9CWZ7 baseline and differential
GenevisibleiQ9CWZ7 MM

Interactioni

Subunit structurei

Binds RIP11 (By similarity). Interacts with VTI1A.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi223846, 2 interactors
IntActiQ9CWZ7, 3 interactors
MINTiQ9CWZ7
STRINGi10090.ENSMUSP00000025474

Structurei

3D structure databases

ProteinModelPortaliQ9CWZ7
SMRiQ9CWZ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SNAP family.Curated

Phylogenomic databases

eggNOGiKOG1585 Eukaryota
ENOG410ZYD7 LUCA
GeneTreeiENSGT00390000010109
HOGENOMiHOG000007747
HOVERGENiHBG001648
InParanoidiQ9CWZ7
KOiK21198
OMAiPYEQAGM
PhylomeDBiQ9CWZ7
TreeFamiTF312872

Family and domain databases

CDDicd15832 SNAP, 1 hit
Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR000744 NSF_attach
IPR011990 TPR-like_helical_dom_sf
PANTHERiPTHR13768 PTHR13768, 1 hit
SUPFAMiSSF48452 SSF48452, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9CWZ7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAQKINEGL EHLAKAEKYL KTGFLKWKPD YDSAASEYGK AAVAFKNAKQ
60 70 80 90 100
FEQAKDACLR EAVAHENNRA LFHAAKAYEQ AGMMLKEMQK LPEAVQLIEK
110 120 130 140 150
ASMMYLENGT PDTAAMALER AGKLIENVDP EKAVQLYQQT ANVFENEERL
160 170 180 190 200
RQAVELLGKA SRLLVRGRRF DEAALSIQKE KNIYKEIENY PTCYKKTIAQ
210 220 230 240 250
VLVHLHRNDY VAAERCVRES YSIPGFNGSE DCAALEQLLE GYDQQDQDQV
260 270 280 290 300
SEVCNSPLFK YMDNDYAKLG LSLVVPGGGI KKKSPATPQA KPDGAAGMAA
310
EEEEDEYSGG LC
Length:312
Mass (Da):34,732
Last modified:June 1, 2001 - v1
Checksum:i12F47490EAFC57F3
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z4B2D3Z4B2_MOUSE
Gamma-soluble NSF attachment protei...
Napg
353Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010275 mRNA Translation: BAB26812.1
AK154573 mRNA Translation: BAE32685.1
AK164149 mRNA Translation: BAE37651.1
AK167372 mRNA Translation: BAE39468.1
BC026977 mRNA Translation: AAH26977.1
CCDSiCCDS29295.1
RefSeqiNP_082293.1, NM_028017.1
UniGeneiMm.292687

Genome annotation databases

EnsembliENSMUST00000025474; ENSMUSP00000025474; ENSMUSG00000024581
GeneIDi108123
KEGGimmu:108123
UCSCiuc008fdp.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010275 mRNA Translation: BAB26812.1
AK154573 mRNA Translation: BAE32685.1
AK164149 mRNA Translation: BAE37651.1
AK167372 mRNA Translation: BAE39468.1
BC026977 mRNA Translation: AAH26977.1
CCDSiCCDS29295.1
RefSeqiNP_082293.1, NM_028017.1
UniGeneiMm.292687

3D structure databases

ProteinModelPortaliQ9CWZ7
SMRiQ9CWZ7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi223846, 2 interactors
IntActiQ9CWZ7, 3 interactors
MINTiQ9CWZ7
STRINGi10090.ENSMUSP00000025474

PTM databases

iPTMnetiQ9CWZ7
PhosphoSitePlusiQ9CWZ7
SwissPalmiQ9CWZ7

Proteomic databases

EPDiQ9CWZ7
MaxQBiQ9CWZ7
PaxDbiQ9CWZ7
PeptideAtlasiQ9CWZ7
PRIDEiQ9CWZ7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025474; ENSMUSP00000025474; ENSMUSG00000024581
GeneIDi108123
KEGGimmu:108123
UCSCiuc008fdp.2 mouse

Organism-specific databases

CTDi8774
MGIiMGI:104561 Napg

Phylogenomic databases

eggNOGiKOG1585 Eukaryota
ENOG410ZYD7 LUCA
GeneTreeiENSGT00390000010109
HOGENOMiHOG000007747
HOVERGENiHBG001648
InParanoidiQ9CWZ7
KOiK21198
OMAiPYEQAGM
PhylomeDBiQ9CWZ7
TreeFamiTF312872

Enzyme and pathway databases

ReactomeiR-MMU-204005 COPII-mediated vesicle transport
R-MMU-6807878 COPI-mediated anterograde transport
R-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-MMU-6811438 Intra-Golgi traffic
R-MMU-6811440 Retrograde transport at the Trans-Golgi-Network

Miscellaneous databases

ChiTaRSiNapg mouse
PROiPR:Q9CWZ7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024581 Expressed in 271 organ(s), highest expression level in Ammon's horn
ExpressionAtlasiQ9CWZ7 baseline and differential
GenevisibleiQ9CWZ7 MM

Family and domain databases

CDDicd15832 SNAP, 1 hit
Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR000744 NSF_attach
IPR011990 TPR-like_helical_dom_sf
PANTHERiPTHR13768 PTHR13768, 1 hit
SUPFAMiSSF48452 SSF48452, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSNAG_MOUSE
AccessioniPrimary (citable) accession number: Q9CWZ7
Secondary accession number(s): Q3TPT4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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