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Protein

N-lysine methyltransferase SETD6

Gene

Setd6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protein-lysine N-methyltransferase. Monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF-kappa-B transcription factor activity. Monomethylates 'Lys-8' of H2AZ (H2AZK8me1) (By similarity). Required for the maintenance of embryonic stem cell self-renewal (PubMed:23324626).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

ReactomeiR-MMU-3214841 PKMTs methylate histone lysines

Names & Taxonomyi

Protein namesi
Recommended name:
N-lysine methyltransferase SETD6 (EC:2.1.1.-)
Alternative name(s):
SET domain-containing protein 6
Gene namesi
Name:Setd6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1913333 Setd6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002818901 – 473N-lysine methyltransferase SETD6Add BLAST473

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphoserineCombined sources1
Modified residuei22PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9CWY3
MaxQBiQ9CWY3
PaxDbiQ9CWY3
PeptideAtlasiQ9CWY3
PRIDEiQ9CWY3

PTM databases

iPTMnetiQ9CWY3
PhosphoSitePlusiQ9CWY3

Expressioni

Gene expression databases

BgeeiENSMUSG00000031671 Expressed in 270 organ(s), highest expression level in ear vesicle
CleanExiMM_SETD6
ExpressionAtlasiQ9CWY3 baseline and differential
GenevisibleiQ9CWY3 MM

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GTF2IRD1Q9UHL93EBI-10768425,EBI-372530From Homo sapiens.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi426098, 1 interactor
IntActiQ9CWY3, 2 interactors
MINTiQ9CWY3
STRINGi10090.ENSMUSP00000034096

Structurei

3D structure databases

ProteinModelPortaliQ9CWY3
SMRiQ9CWY3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini62 – 286SETPROSITE-ProRule annotationAdd BLAST225

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1338 Eukaryota
ENOG410ZN0H LUCA
GeneTreeiENSGT00910000144298
HOGENOMiHOG000264234
HOVERGENiHBG108475
InParanoidiQ9CWY3
KOiK05302
OMAiTCSIGGL
OrthoDBiEOG091G068E
PhylomeDBiQ9CWY3
TreeFamiTF106399

Family and domain databases

Gene3Di3.90.1420.10, 1 hit
InterProiView protein in InterPro
IPR011383 N-lys_methylase_SETD6
IPR015353 Rubisco_LSMT_subst-bd
IPR036464 Rubisco_LSMT_subst-bd_sf
IPR001214 SET_dom
PfamiView protein in Pfam
PF09273 Rubis-subs-bind, 1 hit
PF00856 SET, 1 hit
PIRSFiPIRSF011771 RMS1_SET, 1 hit
SUPFAMiSSF81822 SSF81822, 1 hit
PROSITEiView protein in PROSITE
PS50280 SET, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9CWY3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAPAKRARV SGGSPLVAPC PSPRAARAPL PLPAGSSGGE PEGDAVAGFL
60 70 80 90 100
RWCRRVGLEL SPKVTVSRQG TVAGYGMVAR ESVRAGELLF AVPRSALLSP
110 120 130 140 150
HTCSISGLLE RERGALQSLS GWVPLLLALL HELQAPASPW SPYFALWPEL
160 170 180 190 200
GRLEHPMFWP EEERLRLLKG TGVPEAVEKD LVNIRSEYYS IVLPFMEAHS
210 220 230 240 250
DLFSPSVRSL ELYQQLVALV MAYSFQEPLE EDDDEKEPNS PLMVPAADIL
260 270 280 290 300
NHIANHNANL EYSADYLRMV ATQPILEGHE IFNTYGQMAN WQLIHMYGFA
310 320 330 340 350
EPYPNNTDDT ADIQMVTVRD AALQGTKDET EKLLVCERWD FLCKQEMVGE
360 370 380 390 400
EGAFVIGCEE VLTEEELATT LKVLCMPAEE FRDYKERAGW GEEETEDDSL
410 420 430 440 450
AITDIPKLQE SWKRLLRNSV LLTLQTYTTD LKTDQDLLSN KEAYATLSWR
460 470
EQQALQVRYG QKMILHRVLE LTN
Length:473
Mass (Da):52,960
Last modified:June 1, 2001 - v1
Checksum:i36B10A092DF43ECF
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1D5RMH9A0A1D5RMH9_MOUSE
N-lysine methyltransferase SETD6
Setd6
128Annotation score:
A0A1D5RLQ7A0A1D5RLQ7_MOUSE
N-lysine methyltransferase SETD6
Setd6
67Annotation score:

Sequence cautioni

The sequence BAC35846 differs from that shown. Reason: Frameshift at position 449.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti87E → T in BAC35846 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010304 mRNA Translation: BAB26837.1
AK075597 mRNA Translation: BAC35846.1 Frameshift.
AK167753 mRNA Translation: BAE39788.1
CH466525 Genomic DNA Translation: EDL11181.1
BC139198 mRNA Translation: AAI39199.1
BC139199 mRNA Translation: AAI39200.1
CCDSiCCDS22566.1
RefSeqiNP_001030295.1, NM_001035123.3
UniGeneiMm.261321

Genome annotation databases

EnsembliENSMUST00000034096; ENSMUSP00000034096; ENSMUSG00000031671
GeneIDi66083
KEGGimmu:66083
UCSCiuc009myv.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010304 mRNA Translation: BAB26837.1
AK075597 mRNA Translation: BAC35846.1 Frameshift.
AK167753 mRNA Translation: BAE39788.1
CH466525 Genomic DNA Translation: EDL11181.1
BC139198 mRNA Translation: AAI39199.1
BC139199 mRNA Translation: AAI39200.1
CCDSiCCDS22566.1
RefSeqiNP_001030295.1, NM_001035123.3
UniGeneiMm.261321

3D structure databases

ProteinModelPortaliQ9CWY3
SMRiQ9CWY3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi426098, 1 interactor
IntActiQ9CWY3, 2 interactors
MINTiQ9CWY3
STRINGi10090.ENSMUSP00000034096

PTM databases

iPTMnetiQ9CWY3
PhosphoSitePlusiQ9CWY3

Proteomic databases

EPDiQ9CWY3
MaxQBiQ9CWY3
PaxDbiQ9CWY3
PeptideAtlasiQ9CWY3
PRIDEiQ9CWY3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034096; ENSMUSP00000034096; ENSMUSG00000031671
GeneIDi66083
KEGGimmu:66083
UCSCiuc009myv.1 mouse

Organism-specific databases

CTDi79918
MGIiMGI:1913333 Setd6

Phylogenomic databases

eggNOGiKOG1338 Eukaryota
ENOG410ZN0H LUCA
GeneTreeiENSGT00910000144298
HOGENOMiHOG000264234
HOVERGENiHBG108475
InParanoidiQ9CWY3
KOiK05302
OMAiTCSIGGL
OrthoDBiEOG091G068E
PhylomeDBiQ9CWY3
TreeFamiTF106399

Enzyme and pathway databases

ReactomeiR-MMU-3214841 PKMTs methylate histone lysines

Miscellaneous databases

PROiPR:Q9CWY3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031671 Expressed in 270 organ(s), highest expression level in ear vesicle
CleanExiMM_SETD6
ExpressionAtlasiQ9CWY3 baseline and differential
GenevisibleiQ9CWY3 MM

Family and domain databases

Gene3Di3.90.1420.10, 1 hit
InterProiView protein in InterPro
IPR011383 N-lys_methylase_SETD6
IPR015353 Rubisco_LSMT_subst-bd
IPR036464 Rubisco_LSMT_subst-bd_sf
IPR001214 SET_dom
PfamiView protein in Pfam
PF09273 Rubis-subs-bind, 1 hit
PF00856 SET, 1 hit
PIRSFiPIRSF011771 RMS1_SET, 1 hit
SUPFAMiSSF81822 SSF81822, 1 hit
PROSITEiView protein in PROSITE
PS50280 SET, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSETD6_MOUSE
AccessioniPrimary (citable) accession number: Q9CWY3
Secondary accession number(s): B2RTA7, Q8C6I1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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