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Protein

Complex I intermediate-associated protein 30, mitochondrial

Gene

Ndufaf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).By similarity

GO - Molecular functioni

  • unfolded protein binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Complex I intermediate-associated protein 30, mitochondrial
Alternative name(s):
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 1
Gene namesi
Name:Ndufaf1
Synonyms:Cia30
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1916952 Ndufaf1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 24MitochondrionSequence analysisAdd BLAST24
ChainiPRO_000000546525 – 328Complex I intermediate-associated protein 30, mitochondrialAdd BLAST304

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei319PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9CWX2
MaxQBiQ9CWX2
PaxDbiQ9CWX2
PRIDEiQ9CWX2

PTM databases

PhosphoSitePlusiQ9CWX2

Interactioni

Subunit structurei

Part of the mitochondrial complex I assembly (MCIA) complex. The complex comprises at least TMEM126B, CIA30, ECSIT, and ACAD9 (By similarity). Interacts with ECSIT (By similarity). Interacts with ACAD9 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-59193N
IntActiQ9CWX2, 1 interactor
STRINGi10090.ENSMUSP00000028768

Structurei

3D structure databases

ProteinModelPortaliQ9CWX2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CIA30 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2435 Eukaryota
ENOG410XQPB LUCA
HOGENOMiHOG000231763
HOVERGENiHBG050960
InParanoidiQ9CWX2
KOiK18159
PhylomeDBiQ9CWX2
TreeFamiTF314819

Family and domain databases

InterProiView protein in InterPro
IPR008979 Galactose-bd-like_sf
IPR013857 NADH-UbQ_OxRdtase-assoc_prot30
IPR039131 NDUFAF1
PANTHERiPTHR13194 PTHR13194, 1 hit
PfamiView protein in Pfam
PF08547 CIA30, 1 hit
SUPFAMiSSF49785 SSF49785, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9CWX2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSIHKLLTG IYIHKNFLRP RAALPPFVGN HCVDYSSSSL QKKVTSVDRA
60 70 80 90 100
SQQGKTEEGL QGHDHKEVAL DAPSPDRTPE VSFDKAIRDE AIEHFRRLKD
110 120 130 140 150
EIVAHLRGPD GRPLQEVIME QARVVWQFRE KEDLDKWIVT SDKTIGGRSE
160 170 180 190 200
IFLKMSKNNR SALLYGTLSS EPPQDGDSRQ SGYCAMISRI PRGAFERKLS
210 220 230 240 250
YDWSQFNTLY LRVRGDGRPW MVNIRQDTEF IQRKNQMYSY FMFTRGGPYW
260 270 280 290 300
QEVKIPFSKF FFSNQGRVRD VQGPLVLDKI SSIGFTLSDK VDGPFFLEID
310 320
FIGVFTDPAH TEEFAYENSP VLNPRLFR
Length:328
Mass (Da):37,810
Last modified:June 20, 2002 - v2
Checksum:i002B45C840BA6077
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J081A0A0R4J081_MOUSE
Complex I intermediate-associated p...
Ndufaf1
330Annotation score:
A2AQ17A2AQ17_MOUSE
Complex I intermediate-associated p...
Ndufaf1
328Annotation score:

Sequence cautioni

The sequence BAB26855 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC34201 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti30N → S in BAC34201 (PubMed:16141072).Curated1
Sequence conflicti30N → S in BAB26855 (PubMed:16141072).Curated1
Sequence conflicti134L → F in BAB26855 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010328 mRNA Translation: BAB26855.2 Different initiation.
AK050343 mRNA Translation: BAC34201.1 Different initiation.
BC018422 mRNA Translation: AAH18422.1
RefSeqiNP_081451.3, NM_027175.3
XP_006500211.1, XM_006500148.1
XP_006500212.1, XM_006500149.3
UniGeneiMm.5390

Genome annotation databases

GeneIDi69702
KEGGimmu:69702

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010328 mRNA Translation: BAB26855.2 Different initiation.
AK050343 mRNA Translation: BAC34201.1 Different initiation.
BC018422 mRNA Translation: AAH18422.1
RefSeqiNP_081451.3, NM_027175.3
XP_006500211.1, XM_006500148.1
XP_006500212.1, XM_006500149.3
UniGeneiMm.5390

3D structure databases

ProteinModelPortaliQ9CWX2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59193N
IntActiQ9CWX2, 1 interactor
STRINGi10090.ENSMUSP00000028768

PTM databases

PhosphoSitePlusiQ9CWX2

Proteomic databases

EPDiQ9CWX2
MaxQBiQ9CWX2
PaxDbiQ9CWX2
PRIDEiQ9CWX2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi69702
KEGGimmu:69702

Organism-specific databases

CTDi51103
MGIiMGI:1916952 Ndufaf1

Phylogenomic databases

eggNOGiKOG2435 Eukaryota
ENOG410XQPB LUCA
HOGENOMiHOG000231763
HOVERGENiHBG050960
InParanoidiQ9CWX2
KOiK18159
PhylomeDBiQ9CWX2
TreeFamiTF314819

Miscellaneous databases

PROiPR:Q9CWX2
SOURCEiSearch...

Family and domain databases

InterProiView protein in InterPro
IPR008979 Galactose-bd-like_sf
IPR013857 NADH-UbQ_OxRdtase-assoc_prot30
IPR039131 NDUFAF1
PANTHERiPTHR13194 PTHR13194, 1 hit
PfamiView protein in Pfam
PF08547 CIA30, 1 hit
SUPFAMiSSF49785 SSF49785, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCIA30_MOUSE
AccessioniPrimary (citable) accession number: Q9CWX2
Secondary accession number(s): Q8VEI8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: June 20, 2002
Last modified: November 7, 2018
This is version 104 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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