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Protein

Nucleoporin Nup37

Gene

Nup37

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Chromosome partition, Mitosis, mRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-MMU-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-MMU-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-MMU-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-MMU-191859 snRNP Assembly
R-MMU-2467813 Separation of Sister Chromatids
R-MMU-2500257 Resolution of Sister Chromatid Cohesion
R-MMU-3108214 SUMOylation of DNA damage response and repair proteins
R-MMU-3232142 SUMOylation of ubiquitinylation proteins
R-MMU-3301854 Nuclear Pore Complex (NPC) Disassembly
R-MMU-3371453 Regulation of HSF1-mediated heat shock response
R-MMU-4085377 SUMOylation of SUMOylation proteins
R-MMU-4551638 SUMOylation of chromatin organization proteins
R-MMU-4570464 SUMOylation of RNA binding proteins
R-MMU-4615885 SUMOylation of DNA replication proteins
R-MMU-5578749 Transcriptional regulation by small RNAs
R-MMU-5663220 RHO GTPases Activate Formins
R-MMU-68877 Mitotic Prometaphase

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoporin Nup37
Alternative name(s):
Nup107-160 subcomplex subunit Nup37
Gene namesi
Name:Nup37
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1919964 Nup37

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000511101 – 326Nucleoporin Nup37Add BLAST326

Proteomic databases

EPDiQ9CWU9
MaxQBiQ9CWU9
PaxDbiQ9CWU9
PeptideAtlasiQ9CWU9
PRIDEiQ9CWU9

PTM databases

iPTMnetiQ9CWU9
PhosphoSitePlusiQ9CWU9

Expressioni

Gene expression databases

BgeeiENSMUSG00000035351 Expressed in 254 organ(s), highest expression level in embryo
CleanExiMM_NUP37
ExpressionAtlasiQ9CWU9 baseline and differential
GenevisibleiQ9CWU9 MM

Interactioni

Subunit structurei

Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex includes NUP160, NUP133, NUP107, NUP98, NUP85, NUP43, NUP37, SEH1 and SEC13 (By similarity).By similarity

Protein-protein interaction databases

BioGridi213645, 1 interactor
STRINGi10090.ENSMUSP00000059880

Structurei

3D structure databases

ProteinModelPortaliQ9CWU9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati70 – 117WD 1Add BLAST48
Repeati122 – 162WD 2Add BLAST41
Repeati164 – 203WD 3Add BLAST40
Repeati294 – 325WD 4Add BLAST32

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410IQ10 Eukaryota
ENOG410XSZQ LUCA
GeneTreeiENSGT00390000010777
HOGENOMiHOG000007266
HOVERGENiHBG052695
InParanoidiQ9CWU9
KOiK14302
OMAiCWHPEEA
OrthoDBiEOG091G0NYD
TreeFamiTF325769

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR037626 NUP37
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR22806 PTHR22806, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 3 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q9CWU9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKQDATRNAA YTVDCEDYVH VVEFNPFESG DSGNLIAYGG SNYVVVGMCT
60 70 80 90 100
FQEEETDIEG IQYKTLRTFH HGVRVDGIAW SPETKLDSLP PVIKFCTSAA
110 120 130 140 150
DLKIRLFTSD LQDKNEYKVL EGHSDFINDL VFHPKEGQEL ASVSDDHTCR
160 170 180 190 200
IWNLEGKQTA HFLLHSPGMS VCWHPEETFK LMVAEKNGTI RFYDLMAQQA
210 220 230 240 250
ILSLQSEQTP LMSAHWCLKN TFKVGAVAGN DWIIWDITRS SYPQETRPVH
260 270 280 290 300
MDRAHLFRWS AISENLFATT GYPGKMASQF QIHHLGHSQP VLIGSVAVGS
310 320
GLSWHRTLPL CAVGGDHKLL FWVTEI
Length:326
Mass (Da):36,732
Last modified:July 27, 2011 - v2
Checksum:iF620A40BC9E10CE9
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2P6V2A0A1W2P6V2_MOUSE
Nucleoporin Nup37
Nup37
67Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27F → L in BAB26888 (PubMed:16141072).Curated1
Sequence conflicti318K → R in BAB26888 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010370 mRNA Translation: BAB26888.1
AK012890 mRNA Translation: BAB28538.1
AK040463 mRNA Translation: BAC30597.1
AK165537 mRNA Translation: BAE38243.1
CH466539 Genomic DNA Translation: EDL21469.1
CH466539 Genomic DNA Translation: EDL21470.1
CH466539 Genomic DNA Translation: EDL21471.1
BC011102 mRNA Translation: AAH11102.1
BC032180 mRNA Translation: AAH32180.1
CCDSiCCDS24107.1
RefSeqiNP_081467.2, NM_027191.2
NP_082610.1, NM_028334.4
UniGeneiMm.222184

Genome annotation databases

EnsembliENSMUST00000052355; ENSMUSP00000059880; ENSMUSG00000035351
ENSMUST00000169309; ENSMUSP00000129728; ENSMUSG00000035351
GeneIDi69736
KEGGimmu:69736
UCSCiuc007gre.2 mouse

Similar proteinsi

Entry informationi

Entry nameiNUP37_MOUSE
AccessioniPrimary (citable) accession number: Q9CWU9
Secondary accession number(s): Q9CZ80
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: July 27, 2011
Last modified: September 12, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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