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Protein

Ubiquinol-cytochrome-c reductase complex assembly factor 1

Gene

Uqcc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex). Involved in cytochrome b translation and/or stability.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquinol-cytochrome-c reductase complex assembly factor 1
Alternative name(s):
Basic FGF-repressed Zic-binding protein
Short name:
mbFZb
Ubiquinol-cytochrome c reductase complex chaperone CBP3 homolog
Gene namesi
Name:Uqcc1
Synonyms:Bfzb, Uqcc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1929472 Uqcc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002065611 – 295Ubiquinol-cytochrome-c reductase complex assembly factor 1Add BLAST295

Proteomic databases

EPDiQ9CWU6
PaxDbiQ9CWU6
PeptideAtlasiQ9CWU6
PRIDEiQ9CWU6

PTM databases

iPTMnetiQ9CWU6
PhosphoSitePlusiQ9CWU6

Expressioni

Tissue specificityi

In the brain it is restricted to the olfactory bulb, the hippocampus, the piriform cortex and the Purkinje cells.1 Publication

Developmental stagei

Expressed mainly in the developing nervous system from 9.5 dpc onwards. Also detected in the developing eye and the brown fat.1 Publication

Inductioni

Repressed by bFGF; in embryonic stem cells.1 Publication

Gene expression databases

BgeeiENSMUSG00000005882 Expressed in 295 organ(s), highest expression level in brown adipose tissue
ExpressionAtlasiQ9CWU6 baseline and differential
GenevisibleiQ9CWU6 MM

Interactioni

Subunit structurei

Interacts with UQCC2.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000105264

Family & Domainsi

Sequence similaritiesi

Belongs to the CBP3 family.Curated

Phylogenomic databases

eggNOGiKOG2873 Eukaryota
ENOG4111QVY LUCA
GeneTreeiENSGT00390000018118
HOGENOMiHOG000231832
HOVERGENiHBG036492
InParanoidiQ9CWU6
KOiK17662
OMAiCEDPRHL
OrthoDBiEOG091G0H92
PhylomeDBiQ9CWU6
TreeFamiTF313220

Family and domain databases

InterProiView protein in InterPro
IPR021150 Ubiq_cyt_c_chap/UPF0174
IPR007129 Ubiqinol_cyt_c_chaperone_CPB3
PANTHERiPTHR12184 PTHR12184, 1 hit
PfamiView protein in Pfam
PF03981 Ubiq_cyt_C_chap, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9CWU6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALLVRVLRN QTSISQWVPV CSQLVSVSPT QRQWSSTSQW LQKNQSRVCL
60 70 80 90 100
GSEQTVGADT AQNRKYHNTS KLLTTQDFPQ PVEEKVGPFT KIIEAMGFTG
110 120 130 140 150
PLKYSKWKIK IAALRMYTSC VEKTDFEEFF LRCQMPDTFN SWFLITLLHV
160 170 180 190 200
WMCLVRMKQE GRTGKYMCRI IVHFMWEDVE QRGRVMGVNS YILKKNMALM
210 220 230 240 250
TNNFYAAILG YDEGILSDDH GLAAALWRTF FNQKCEDPRQ LELLVEYVRK
260 270 280 290
QMQYLDSMNG EDLLLTGEVR WRPLVEKNPQ SILKPHAPTY NDEGL
Length:295
Mass (Da):34,300
Last modified:June 1, 2001 - v1
Checksum:iAB7D0C9BF6F7B00A
GO
Isoform 2 (identifier: Q9CWU6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     70-70: S → T
     71-207: Missing.

Note: No experimental confirmation available.
Show »
Length:158
Mass (Da):18,104
Checksum:i8C5E5EDA1CA90B64
GO

Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6PWX5A6PWX5_MOUSE
Ubiquinol-cytochrome-c reductase co...
Uqcc1 Uqcc
215Annotation score:
A6PWX9A6PWX9_MOUSE
Ubiquinol-cytochrome-c reductase co...
Uqcc1 Uqcc
269Annotation score:
A6PWX7A6PWX7_MOUSE
Ubiquinol-cytochrome-c reductase co...
Uqcc1 Uqcc
227Annotation score:
A6PWX8A6PWX8_MOUSE
Ubiquinol-cytochrome-c reductase co...
Uqcc1 Uqcc
262Annotation score:
D6RJ83D6RJ83_MOUSE
Ubiquinol-cytochrome-c reductase co...
Uqcc1 Uqcc
120Annotation score:
F6V305F6V305_MOUSE
Ubiquinol-cytochrome-c reductase co...
Uqcc1 Uqcc
243Annotation score:
D6RJ23D6RJ23_MOUSE
Ubiquinol-cytochrome-c reductase co...
Uqcc1 Uqcc
33Annotation score:
D6RDC3D6RDC3_MOUSE
Ubiquinol-cytochrome-c reductase co...
Uqcc1 Uqcc
52Annotation score:
E0CXL8E0CXL8_MOUSE
Ubiquinol-cytochrome-c reductase co...
Uqcc1 Uqcc
45Annotation score:
D6RHP7D6RHP7_MOUSE
Ubiquinol-cytochrome-c reductase co...
Uqcc1 Uqcc
71Annotation score:

Sequence cautioni

The sequence AAF64519 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB27433 differs from that shown. Reason: Erroneous termination at position 72. Translated as Leu.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti97G → V in BAC36749 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00085870S → T in isoform 2. Curated1
Alternative sequenceiVSP_00085971 – 207Missing in isoform 2. CuratedAdd BLAST137

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010376 mRNA Translation: BAB26894.1
AK011152 mRNA Translation: BAB27433.1 Sequence problems.
AK019425 mRNA No translation available.
AK077323 mRNA Translation: BAC36749.1
AK139488 mRNA Translation: BAE24034.1
AK169413 mRNA Translation: BAE41159.1
AL845445 Genomic DNA No translation available.
BC050884 mRNA Translation: AAH50884.1
BC057570 mRNA Translation: AAH57570.1
AF253516 mRNA Translation: AAF64519.1 Different initiation.
CCDSiCCDS16957.2 [Q9CWU6-1]
RefSeqiNP_061376.2, NM_018888.4 [Q9CWU6-1]
UniGeneiMm.158827

Genome annotation databases

EnsembliENSMUST00000109636; ENSMUSP00000105264; ENSMUSG00000005882 [Q9CWU6-1]
GeneIDi56046
KEGGimmu:56046
UCSCiuc008nlo.2 mouse [Q9CWU6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010376 mRNA Translation: BAB26894.1
AK011152 mRNA Translation: BAB27433.1 Sequence problems.
AK019425 mRNA No translation available.
AK077323 mRNA Translation: BAC36749.1
AK139488 mRNA Translation: BAE24034.1
AK169413 mRNA Translation: BAE41159.1
AL845445 Genomic DNA No translation available.
BC050884 mRNA Translation: AAH50884.1
BC057570 mRNA Translation: AAH57570.1
AF253516 mRNA Translation: AAF64519.1 Different initiation.
CCDSiCCDS16957.2 [Q9CWU6-1]
RefSeqiNP_061376.2, NM_018888.4 [Q9CWU6-1]
UniGeneiMm.158827

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000105264

PTM databases

iPTMnetiQ9CWU6
PhosphoSitePlusiQ9CWU6

Proteomic databases

EPDiQ9CWU6
PaxDbiQ9CWU6
PeptideAtlasiQ9CWU6
PRIDEiQ9CWU6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000109636; ENSMUSP00000105264; ENSMUSG00000005882 [Q9CWU6-1]
GeneIDi56046
KEGGimmu:56046
UCSCiuc008nlo.2 mouse [Q9CWU6-1]

Organism-specific databases

CTDi55245
MGIiMGI:1929472 Uqcc1

Phylogenomic databases

eggNOGiKOG2873 Eukaryota
ENOG4111QVY LUCA
GeneTreeiENSGT00390000018118
HOGENOMiHOG000231832
HOVERGENiHBG036492
InParanoidiQ9CWU6
KOiK17662
OMAiCEDPRHL
OrthoDBiEOG091G0H92
PhylomeDBiQ9CWU6
TreeFamiTF313220

Miscellaneous databases

ChiTaRSiUqcc1 mouse
PROiPR:Q9CWU6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000005882 Expressed in 295 organ(s), highest expression level in brown adipose tissue
ExpressionAtlasiQ9CWU6 baseline and differential
GenevisibleiQ9CWU6 MM

Family and domain databases

InterProiView protein in InterPro
IPR021150 Ubiq_cyt_c_chap/UPF0174
IPR007129 Ubiqinol_cyt_c_chaperone_CPB3
PANTHERiPTHR12184 PTHR12184, 1 hit
PfamiView protein in Pfam
PF03981 Ubiq_cyt_C_chap, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUQCC1_MOUSE
AccessioniPrimary (citable) accession number: Q9CWU6
Secondary accession number(s): A2ARK1
, Q3TET9, Q9CRP2, Q9JK78
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 22, 2003
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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