Zdhhc13

Functionⁱ

Palmitoyltransferase for HTT and GAD2 (PubMed:19299482). May play a role in Mg²⁺ transport (PubMed:18794299).2 Publications

Catalytic activityⁱ

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Active siteⁱ	456	S-palmitoyl cysteine intermediateBy similarity		1

GO - Molecular functionⁱ

magnesium ion transmembrane transporter activity
Source: UniProtKB
Inferred from direct assayⁱ
- 18794299
palmitoyltransferase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 18794299
protein-cysteine S-palmitoyltransferase activity Source: UniProtKB-EC

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Acyltransferase, Transferase

Molecular function

Acyltransferase, Transferase

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Palmitoyltransferase ZDHHC13Curated (EC:2.3.1.2251 Publication) Alternative name(s): Huntingtin-interacting protein 14-related protein1 Publication Short name: HIP14-related protein1 Publication Zinc finger DHHC domain-containing protein 13Imported Short name: DHHC-131 Publication
Gene namesⁱ	Name:Zdhhc13Imported Synonyms:Hip14l
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 7

Organism-specific databases

MGIⁱ	MGI:1919227 Zdhhc13

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	292 – 312	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	321 – 341	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	348 – 368	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	372 – 392	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	471 – 491	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	519 – 539	HelicalSequence analysisAdd BLAST	21

Keywords - Cellular componentⁱ

Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000212889	1 – 622	Palmitoyltransferase ZDHHC13Add BLAST		622

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	1	N-acetylmethionineBy similarity		1

Keywords - PTMⁱ

Acetylation, Lipoprotein, Palmitate

Proteomic databases

EPDⁱ	Q9CWU2
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9CWU2
PaxDbⁱ	Q9CWU2
PeptideAtlas More...PeptideAtlasⁱ	Q9CWU2
PRIDEⁱ	Q9CWU2

PTM databases

iPTMnetⁱ	Q9CWU2
PhosphoSitePlusⁱ	Q9CWU2
SwissPalmⁱ	Q9CWU2

Expressionⁱ

Inductionⁱ

Up-regulated by low extracellular Mg²⁺.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000030471 Expressed in 253 organ(s), highest expression level in decidua
CleanExⁱ	MM_ZDHHC13
ExpressionAtlasⁱ	Q9CWU2 baseline and differential
Genevisibleⁱ	Q9CWU2 MM

Interactionⁱ

Subunit structureⁱ

Interacts (via ANK repeats) with CLIP3 (PubMed:26198635). Interacts (via ANK repeats) with DNAJC5 (via C-terminus) (PubMed:25253725, PubMed:26198635). Interacts (via ANK repeats) with HTT (PubMed:26198635). Interacts (via ANK repeats) with MAP6 (PubMed:26198635). Interacts (via ANK repeats) with SNAP23 (PubMed:26198635). Interacts (via ANK repeats) with SNAP25 (PubMed:25253725, PubMed:26198635). May interact (via ANK repeats) with SPRED2 (PubMed:28882895).3 Publications

Protein-protein interaction databases

BioGridⁱ	232597, 4 interactors
IntActⁱ	Q9CWU2, 1 interactor
Molecular INTeraction database More...MINTⁱ	Q9CWU2
STRINGⁱ	10090.ENSMUSP00000112498

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9CWU2
SMRⁱ	Q9CWU2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	43 – 78	ANK 1By similarityAdd BLAST	36
Repeatⁱ	81 – 110	ANK 2Sequence analysisAdd BLAST	30
Repeatⁱ	115 – 144	ANK 3Sequence analysisAdd BLAST	30
Repeatⁱ	148 – 177	ANK 4Sequence analysisAdd BLAST	30
Repeatⁱ	181 – 211	ANK 5Sequence analysisAdd BLAST	31
Repeatⁱ	216 – 245	ANK 6Sequence analysisAdd BLAST	30
Repeatⁱ	249 – 277	ANK 7Sequence analysisAdd BLAST	29
Domainⁱ	426 – 476	DHHCPROSITE-ProRule annotationAdd BLAST	51

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	328 – 391	Phe-richAdd BLAST		64

Domainⁱ

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesⁱ

Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.Curated

Keywords - Domainⁱ

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0509 Eukaryota COG0666 LUCA COG5273 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063074
HOGENOMⁱ	HOG000290181
HOVERGENⁱ	HBG051907
InParanoidⁱ	Q9CWU2
KEGG Orthology (KO) More...KOⁱ	K20032
OMAⁱ	QCRNHSH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G056H
PhylomeDBⁱ	Q9CWU2
TreeFamⁱ	TF317342

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00204 ANK, 2 hits
Gene3Dⁱ	1.25.40.20, 1 hit
InterProⁱ	View protein in InterPro IPR002110 Ankyrin_rpt IPR020683 Ankyrin_rpt-contain_dom IPR036770 Ankyrin_rpt-contain_sf IPR001594 Palmitoyltrfase_DHHC IPR030290 ZDHHC13
PANTHERⁱ	PTHR24161:SF16 PTHR24161:SF16, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12796 Ank_2, 1 hit PF01529 DHHC, 1 hit
SMARTⁱ	View protein in SMART SM00248 ANK, 6 hits
SUPFAMⁱ	SSF48403 SSF48403, 1 hit
PROSITEⁱ	View protein in PROSITE PS50297 ANK_REP_REGION, 1 hit PS50088 ANK_REPEAT, 4 hits PS50216 DHHC, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.ⁱShow all

Q9CWU2-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEGPGLGSQC RNHSHGSHVP GFGRHGICVH ENKELAKAKE ILPLIEDSSN 
        60         70         80         90        100
CDIVKATQYG IFERCKELVE AGYDVRQPDR ENVSLLHWAA INNRLELVKF 
       110        120        130        140        150
YISKGAVIDQ LGGDLNSTPL HWAIRQGHLP MVILLLQHGA DPTLIDGEGF 
       160        170        180        190        200
SSIHLAVLFQ HMPIIAYLIS KGQSVNMTDV NGQTPLMLSA YKVIGPEPTG 
       210        220        230        240        250
FLLKFNPSLS VVDKTHQNTP LHWAVAAGNV SAVDKLLEAG SSLDIRNAKG 
       260        270        280        290        300
ETPLDMALQS KNQLISHMLR TEAKMRANKQ FRLWRWLHKC ELFLLLILSM 
       310        320        330        340        350
ITLWAVGYIL DFNSDSWLLK GCLLVALFFL TSLFPRFLVG YKNLVYLPTV 
       360        370        380        390        400
FLLSSIFWIF MTWFILFFPD TAGSPLYFAF IFSIMAFLYF FYKTWATDPG 
       410        420        430        440        450
FTKASEEERK VNIVTLAETG SLDFRTFCTS CLIRKPLRSL HCHVCNSCVA 
       460        470        480        490        500
RFDQHCFWTG RCIGFGNHHH YIFFLLSLSM VCDWIIYGSF VYWSNHCATT 
       510        520        530        540        550
FKEDGLWTYL NQIVACSPWV LYIFMLAAFH FSWSTFLLIN QLFQIAFLGL 
       560        570        580        590        600
TSHERISLLK QSRHMKQTLS LRKTPYNLGF TQNLADFFQC GCFGLVKPCI 
       610        620 
IDWTSQYTMV FHPAKEKVLR SV

Length:622

Mass (Da):70,890

Last modified:March 1, 2003 - v2

Checksum:ⁱC34EB8AB76899E72

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation
	D3YY07	D3YY07_MOUSE		Palmitoyltransferase Palmitoyltransferase, EC 2.3.1.225	Zdhhc13	442	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	110	Q → L in BAE26700 (PubMed:16141072).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK010382 mRNA Translation: BAB26899.2 AK145855 mRNA Translation: BAE26700.1 AK146196 mRNA Translation: BAE26970.1 BC046599 mRNA Translation: AAH46599.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS52259.1
NCBI Reference Sequences More...RefSeqⁱ	NP_082307.1, NM_028031.3
UniGeneⁱ	Mm.279116

Genome annotation databases

Ensemblⁱ	ENSMUST00000118927; ENSMUSP00000112498; ENSMUSG00000030471
GeneIDⁱ	243983
KEGGⁱ	mmu:243983
UCSC genome browser More...UCSCⁱ	uc009haw.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9CWU2	Palmitoyltransferase (Fragment)		MOUSE		442	UniRef100_Q9CWU2
UPI0003D709A2		MOUSE		492

Protein	Similar proteins		Species	Score	Length	Source
Q9CWU2	Palmitoyltransferase (Fragment)		MOUSE		442	UniRef90_Q9CWU2
Palmitoyltransferase		PANTR		701
Palmitoyltransferase		ICTTR		622
Palmitoyltransferase		RABIT		622
Palmitoyltransferase		HETGA		622
+28

Protein	Similar proteins		Species	Score	Length	Source
Q9CWU2	Palmitoyltransferase ZDHHC13		HUMAN		622	UniRef50_Q8IUH4
Palmitoyltransferase ZDHHC13		PONAB		622
Palmitoyltransferase ZDHHC13		MACFA		622
Palmitoyltransferase		TURTR		729
palmitoyltransferase ZDHHC13		PHYCD		729
+378

Entry informationⁱ

Entry nameⁱ	ZDH13_MOUSE
Accessionⁱ	Q9CWU2Primary (citable) accession number: Q9CWU2 Secondary accession number(s): Q3UK32, Q3UKV1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
	Last sequence update:	March 1, 2003
	Last modified:	September 12, 2018
	This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9CWU2 (ZDH13_MOUSE)

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Palmitoyltransferase ZDHHC13

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Golgi apparatus

Other locations

Endoplasmic reticulum

Golgi apparatus

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi