UniProtKB - Q9CWU2 (ZDH13_MOUSE)
Palmitoyltransferase ZDHHC13
Zdhhc13
Functioni
Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates (PubMed:18794299, PubMed:19299482).
Palmitoyltransferase for HTT and GAD2 (PubMed:19299482, PubMed:20548961).
May play a role in Mg2+ transport (PubMed:18794299).
2 PublicationsCatalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 456 | S-palmitoyl cysteine intermediatePROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- magnesium ion transmembrane transporter activity Source: UniProtKB
- palmitoyltransferase activity Source: UniProtKB
- protein-cysteine S-palmitoyltransferase activity Source: UniProtKB-EC
GO - Biological processi
- protein palmitoylation Source: GO_Central
Keywordsi
Molecular function | Acyltransferase, Transferase |
Names & Taxonomyi
Protein namesi | Recommended name: Palmitoyltransferase ZDHHC13Curated (EC:2.3.1.2252 Publications)Alternative name(s): Huntingtin-interacting protein 14-related protein1 Publication Short name: HIP14-related protein1 Publication Zinc finger DHHC domain-containing protein 13Imported Short name: DHHC-131 Publication |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1919227, Zdhhc13 |
VEuPathDBi | HostDB:ENSMUSG00000030471 |
Subcellular locationi
Golgi apparatus
- Golgi apparatus membrane 3 Publications; Multi-pass membrane protein Sequence analysis
Other locations
- Cytoplasmic vesicle membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Note: Low extracellular Mg2+ induces increase in Golgi and in post-Golgi vesicles.1 Publication
Endoplasmic reticulum
- endoplasmic reticulum Source: MGI
Golgi apparatus
- Golgi apparatus Source: UniProtKB
- Golgi membrane Source: UniProtKB
Other locations
- Golgi-associated vesicle membrane Source: UniProtKB
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 291 | CytoplasmicCuratedAdd BLAST | 291 | |
Transmembranei | 292 – 312 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 313 – 320 | LumenalCurated | 8 | |
Transmembranei | 321 – 341 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 342 – 347 | CytoplasmicCurated | 6 | |
Transmembranei | 348 – 368 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 369 – 371 | LumenalCurated | 3 | |
Transmembranei | 372 – 392 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 393 – 470 | CytoplasmicCuratedAdd BLAST | 78 | |
Transmembranei | 471 – 491 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 492 – 518 | LumenalCuratedAdd BLAST | 27 | |
Transmembranei | 519 – 539 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 540 – 622 | CytoplasmicCuratedAdd BLAST | 83 |
Keywords - Cellular componenti
Cytoplasmic vesicle, Golgi apparatus, MembranePathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000212889 | 1 – 622 | Palmitoyltransferase ZDHHC13Add BLAST | 622 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 |
Keywords - PTMi
Acetylation, Lipoprotein, PalmitateProteomic databases
EPDi | Q9CWU2 |
MaxQBi | Q9CWU2 |
PaxDbi | Q9CWU2 |
PeptideAtlasi | Q9CWU2 |
PRIDEi | Q9CWU2 |
ProteomicsDBi | 298513 |
PTM databases
iPTMneti | Q9CWU2 |
PhosphoSitePlusi | Q9CWU2 |
SwissPalmi | Q9CWU2 |
Expressioni
Tissue specificityi
Developmental stagei
Inductioni
Gene expression databases
Bgeei | ENSMUSG00000030471, Expressed in decidua and 277 other tissues |
Genevisiblei | Q9CWU2, MM |
Interactioni
Subunit structurei
Interacts (via ANK repeats) with CLIP3 (PubMed:26198635).
Interacts (via ANK repeats) with DNAJC5 (via C-terminus) (PubMed:25253725, PubMed:26198635).
Interacts (via ANK repeats) with HTT (PubMed:26198635).
Interacts (via ANK repeats) with MAP6 (PubMed:26198635).
Interacts (via ANK repeats) with SNAP23 (PubMed:26198635).
Interacts (via ANK repeats) with SNAP25 (PubMed:25253725, PubMed:26198635). May interact (via ANK repeats) with SPRED2 (PubMed:28882895).
3 PublicationsProtein-protein interaction databases
BioGRIDi | 232597, 4 interactors |
IntActi | Q9CWU2, 3 interactors |
STRINGi | 10090.ENSMUSP00000112498 |
Miscellaneous databases
RNActi | Q9CWU2, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 43 – 78 | ANK 1By similarityAdd BLAST | 36 | |
Repeati | 81 – 110 | ANK 2Sequence analysisAdd BLAST | 30 | |
Repeati | 115 – 144 | ANK 3Sequence analysisAdd BLAST | 30 | |
Repeati | 148 – 177 | ANK 4Sequence analysisAdd BLAST | 30 | |
Repeati | 181 – 211 | ANK 5Sequence analysisAdd BLAST | 31 | |
Repeati | 216 – 245 | ANK 6Sequence analysisAdd BLAST | 30 | |
Repeati | 249 – 277 | ANK 7Sequence analysisAdd BLAST | 29 | |
Domaini | 426 – 476 | DHHCPROSITE-ProRule annotationAdd BLAST | 51 |
Domaini
Sequence similaritiesi
Keywords - Domaini
ANK repeat, Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0509, Eukaryota |
GeneTreei | ENSGT00530000063074 |
HOGENOMi | CLU_012510_3_1_1 |
InParanoidi | Q9CWU2 |
OMAi | HTCWSTL |
OrthoDBi | 445686at2759 |
PhylomeDBi | Q9CWU2 |
TreeFami | TF317342 |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf IPR001594, Palmitoyltrfase_DHHC IPR030290, ZDHHC13 |
PANTHERi | PTHR24161:SF16, PTHR24161:SF16, 1 hit |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit PF13637, Ank_4, 1 hit PF13857, Ank_5, 1 hit PF01529, DHHC, 1 hit |
SMARTi | View protein in SMART SM00248, ANK, 6 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 4 hits PS50216, DHHC, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MEGPGLGSQC RNHSHGSHVP GFGRHGICVH ENKELAKAKE ILPLIEDSSN
60 70 80 90 100
CDIVKATQYG IFERCKELVE AGYDVRQPDR ENVSLLHWAA INNRLELVKF
110 120 130 140 150
YISKGAVIDQ LGGDLNSTPL HWAIRQGHLP MVILLLQHGA DPTLIDGEGF
160 170 180 190 200
SSIHLAVLFQ HMPIIAYLIS KGQSVNMTDV NGQTPLMLSA YKVIGPEPTG
210 220 230 240 250
FLLKFNPSLS VVDKTHQNTP LHWAVAAGNV SAVDKLLEAG SSLDIRNAKG
260 270 280 290 300
ETPLDMALQS KNQLISHMLR TEAKMRANKQ FRLWRWLHKC ELFLLLILSM
310 320 330 340 350
ITLWAVGYIL DFNSDSWLLK GCLLVALFFL TSLFPRFLVG YKNLVYLPTV
360 370 380 390 400
FLLSSIFWIF MTWFILFFPD TAGSPLYFAF IFSIMAFLYF FYKTWATDPG
410 420 430 440 450
FTKASEEERK VNIVTLAETG SLDFRTFCTS CLIRKPLRSL HCHVCNSCVA
460 470 480 490 500
RFDQHCFWTG RCIGFGNHHH YIFFLLSLSM VCDWIIYGSF VYWSNHCATT
510 520 530 540 550
FKEDGLWTYL NQIVACSPWV LYIFMLAAFH FSWSTFLLIN QLFQIAFLGL
560 570 580 590 600
TSHERISLLK QSRHMKQTLS LRKTPYNLGF TQNLADFFQC GCFGLVKPCI
610 620
IDWTSQYTMV FHPAKEKVLR SV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketD3YY07 | D3YY07_MOUSE | Palmitoyltransferase | Zdhhc13 | 442 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 110 | Q → L in BAE26700 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK010382 mRNA Translation: BAB26899.2 AK145855 mRNA Translation: BAE26700.1 AK146196 mRNA Translation: BAE26970.1 BC046599 mRNA Translation: AAH46599.1 |
CCDSi | CCDS52259.1 |
RefSeqi | NP_082307.1, NM_028031.3 |
Genome annotation databases
Ensembli | ENSMUST00000118927; ENSMUSP00000112498; ENSMUSG00000030471 |
GeneIDi | 243983 |
KEGGi | mmu:243983 |
UCSCi | uc009haw.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK010382 mRNA Translation: BAB26899.2 AK145855 mRNA Translation: BAE26700.1 AK146196 mRNA Translation: BAE26970.1 BC046599 mRNA Translation: AAH46599.1 |
CCDSi | CCDS52259.1 |
RefSeqi | NP_082307.1, NM_028031.3 |
3D structure databases
SMRi | Q9CWU2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 232597, 4 interactors |
IntActi | Q9CWU2, 3 interactors |
STRINGi | 10090.ENSMUSP00000112498 |
PTM databases
iPTMneti | Q9CWU2 |
PhosphoSitePlusi | Q9CWU2 |
SwissPalmi | Q9CWU2 |
Proteomic databases
EPDi | Q9CWU2 |
MaxQBi | Q9CWU2 |
PaxDbi | Q9CWU2 |
PeptideAtlasi | Q9CWU2 |
PRIDEi | Q9CWU2 |
ProteomicsDBi | 298513 |
Protocols and materials databases
Antibodypediai | 6224, 172 antibodies from 35 providers |
DNASUi | 243983 |
Genome annotation databases
Ensembli | ENSMUST00000118927; ENSMUSP00000112498; ENSMUSG00000030471 |
GeneIDi | 243983 |
KEGGi | mmu:243983 |
UCSCi | uc009haw.1, mouse |
Organism-specific databases
CTDi | 54503 |
MGIi | MGI:1919227, Zdhhc13 |
VEuPathDBi | HostDB:ENSMUSG00000030471 |
Phylogenomic databases
eggNOGi | KOG0509, Eukaryota |
GeneTreei | ENSGT00530000063074 |
HOGENOMi | CLU_012510_3_1_1 |
InParanoidi | Q9CWU2 |
OMAi | HTCWSTL |
OrthoDBi | 445686at2759 |
PhylomeDBi | Q9CWU2 |
TreeFami | TF317342 |
Miscellaneous databases
BioGRID-ORCSi | 243983, 2 hits in 64 CRISPR screens |
PROi | PR:Q9CWU2 |
RNActi | Q9CWU2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000030471, Expressed in decidua and 277 other tissues |
Genevisiblei | Q9CWU2, MM |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf IPR001594, Palmitoyltrfase_DHHC IPR030290, ZDHHC13 |
PANTHERi | PTHR24161:SF16, PTHR24161:SF16, 1 hit |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit PF13637, Ank_4, 1 hit PF13857, Ank_5, 1 hit PF01529, DHHC, 1 hit |
SMARTi | View protein in SMART SM00248, ANK, 6 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 4 hits PS50216, DHHC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ZDH13_MOUSE | |
Accessioni | Q9CWU2Primary (citable) accession number: Q9CWU2 Secondary accession number(s): Q3UK32, Q3UKV1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 13, 2004 |
Last sequence update: | March 1, 2003 | |
Last modified: | February 23, 2022 | |
This is version 150 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families