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Entry version 130 (12 Aug 2020)
Sequence version 2 (04 Dec 2007)
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Protein

Putative ATP-dependent RNA helicase TDRD12

Gene

Tdrd12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable ATP-binding RNA helicase required during spermatogenesis to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (PubMed:24067652). Involved in the secondary piRNAs metabolic process (PubMed:24067652). Acts via the PET complex, a multiprotein complex required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs (PubMed:26669262).2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi453 – 460ATPBy similarity8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Helicase, Hydrolase
Biological processDifferentiation, Meiosis, RNA-mediated gene silencing, Spermatogenesis
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Putative ATP-dependent RNA helicase TDRD12 (EC:3.6.4.13)
Alternative name(s):
ES cell-associated transcript 8 protein
Tudor domain-containing protein 12
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tdrd12
Synonyms:Ecat8, Repro23
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1919231, Tdrd12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice are viable but show male sterility with chromosome synapsis failure. Male mice display atrophied testes, with seminiferous tubules that are narrow with large vacuolated spaces, devoid of late-stage germ cells. Retrotransposons are derepressed due to DNA demethylation.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003119691 – 1215Putative ATP-dependent RNA helicase TDRD12Add BLAST1215

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9CWU0

PRoteomics IDEntifications database

More...
PRIDEi
Q9CWU0

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9CWU0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9CWU0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Restricted to the gonads.2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed from embryonic to the adult stages in testis. Expressed in embryonic stem (ES) cells.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000030491, Expressed in oocyte and 69 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9CWU0, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of a mRNP complex containing PIWIL2, TDRD1 and piRNAs (PubMed:24067652).

Component of the PET complex, at least composed of EXD1, PIWIL2, TDRD12 and piRNAs (PubMed:26669262).

2 Publications

Protein-protein interaction databases

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9CWU0

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000032701

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9CWU0, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini56 – 118Tudor 1Add BLAST63
Domaini440 – 628Helicase ATP-bindingAdd BLAST189
Domaini809 – 909Tudor 2Add BLAST101
Domaini1073 – 1159CSPROSITE-ProRule annotationAdd BLAST87

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi567 – 570DEAH box4

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0331, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000166448

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9CWU0

KEGG Orthology (KO)

More...
KOi
K18409

Database of Orthologous Groups

More...
OrthoDBi
231240at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9CWU0

TreeFam database of animal gene trees

More...
TreeFami
TF332354

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.50.90, 2 hits
2.60.40.790, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007052, CS_dom
IPR011545, DEAD/DEAH_box_helicase_dom
IPR008978, HSP20-like_chaperone
IPR027417, P-loop_NTPase
IPR035437, SNase_OB-fold_sf
IPR002999, Tudor

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04969, CS, 1 hit
PF00270, DEAD, 1 hit
PF00567, TUDOR, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49764, SSF49764, 1 hit
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51203, CS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9CWU0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFEVLVLKIE DPGCFWVIIK GCSHFLEQEV DYQKLNTAMN DFYNSMCQDV
60 70 80 90 100
EMKPLMLEEG QVCVVYCQEL KCWCRALIKS IISSADHYLA ECFLVDFAKY
110 120 130 140 150
IPVKSKNIRV AVESFMQLPY RAKKFRLYGT KPVTLHIDFC EDNAEIVPAT
160 170 180 190 200
KWDSAAIQYF QNLLRATTQV EAKLCAVEED TFEVYLYATI KNEKVCVNDD
210 220 230 240 250
LVAKNFAYYV SPMGNKNLNP LEKPRQSLNS VTCSSKLSPS LTLWPMLLQG
260 270 280 290 300
KDYHRMENKA LNYKDSLTDS PKMMLEKQQQ SLPLKHTEKC TESSVYWPTK
310 320 330 340 350
RGITIYADPD VPSVSGSSQR PNEKPLRLTE KKDCDEKNGC VKLLQFLNPD
360 370 380 390 400
PLRADGTSDL HQLQKVKLGT LQPGVVLRNR IEPCLTLEKS PLSADLKKMA
410 420 430 440 450
LTCLNSDTED MKVAMEEMIP PEALQRNKFP GPSHTASYSW PPIARGCDMV
460 470 480 490 500
VISHCGNDPL LYLPPLLTIL QMGGCYKSLP SRNGPLAVIV CPGWKKAQFI
510 520 530 540 550
FELLGDYSMS SRPLHPVLLT IGLHKDEAKN MKLPRGCDVI VTTPHSLLRL
560 570 580 590 600
LTYRSLLFLR LCHLVLDEVH MLFFEANEQM FAILDNFKKN VEVEERESAP
610 620 630 640 650
HQIVAVGVHW NKHIDHLVRE FMKDPCVVIT ALEEAALYGS VQQVVHLCLE
660 670 680 690 700
CEKTSTLLQV LDFVPSQAQK TLIFTCSVAE TETVCKGSPA EQGDKKTKSV
710 720 730 740 750
LLLTERNASH AVGILRYLER ADAKIPSELY EFTAGVLEAK EDKKARRPLC
760 770 780 790 800
PYLKAFGFCK DKRICPDRHH INPEMDIPRK LSNKTLPVFG HIRVIPFYIS
810 820 830 840 850
NATNYFGRII DKHVDLYETL NAEMNEYFKE SSNKTSAEKV ENLGLYGLEE
860 870 880 890 900
KTLFQRVQVL EVSQKEDTWG LGSILVKLID EGRTKLITRD QLLLLPEKFH
910 920 930 940 950
TLPPQAVEFI VCRVKPADSE IEWNPKVTRY IHHKIVGKMH DAKVVLALGN
960 970 980 990 1000
TLWIDPMVHV TKLSNLKTSI IDYNVRAEIL SMGMGIDNSE HLEQLKKLYK
1010 1020 1030 1040 1050
EAKLPAFEDL PCQTSIPTTV EDTVCLQGTQ QGDGGTERGA GSQEDSDNQK
1060 1070 1080 1090 1100
PGVLSEDIGS ETISSAPQPH GRSFHPQIKW FQKDDVVILK IKIRNVKDYK
1110 1120 1130 1140 1150
CKFFTDRVIF SAWVGDKFYL ADLELQGDIR KDDCKCIIKD DEPLITLAKE
1160 1170 1180 1190 1200
KQECWCGLLK QRNPNVAFDF DHWEECEEDS PFSKVVNSKN LSCKVAALAE
1210
SSGSSSDTTD GSESE
Length:1,215
Mass (Da):137,627
Last modified:December 4, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4EF202AFB8B86D8D
GO
Isoform 2 (identifier: Q9CWU0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     399-407: MALTCLNSD → VNMFLKPDS
     408-1215: Missing.

Show »
Length:407
Mass (Da):46,519
Checksum:iAD953730FC817C6E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WQS9A0A087WQS9_MOUSE
Putative ATP-dependent RNA helicase...
Tdrd12
1,113Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A6YX17A0A0A6YX17_MOUSE
Putative ATP-dependent RNA helicase...
Tdrd12
1,216Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RNP6A0A0U1RNP6_MOUSE
Putative ATP-dependent RNA helicase...
Tdrd12
127Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3YZI6D3YZI6_MOUSE
Putative ATP-dependent RNA helicase...
Tdrd12
204Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RNL0A0A0U1RNL0_MOUSE
Putative ATP-dependent RNA helicase...
Tdrd12
354Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti318S → SY in AC151535 (PubMed:19468303).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_029677399 – 407MALTCLNSD → VNMFLKPDS in isoform 2. 2 Publications9
Alternative sequenceiVSP_029678408 – 1215Missing in isoform 2. 2 PublicationsAdd BLAST808

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB211061 mRNA Translation: BAD95488.1
AK010386 mRNA Translation: BAB26901.1
AC151535 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS21151.1 [Q9CWU0-2]

NCBI Reference Sequences

More...
RefSeqi
NP_082310.1, NM_028034.2 [Q9CWU0-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000032701; ENSMUSP00000032701; ENSMUSG00000030491 [Q9CWU0-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
71981

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:71981

UCSC genome browser

More...
UCSCi
uc012fij.1, mouse [Q9CWU0-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB211061 mRNA Translation: BAD95488.1
AK010386 mRNA Translation: BAB26901.1
AC151535 Genomic DNA No translation available.
CCDSiCCDS21151.1 [Q9CWU0-2]
RefSeqiNP_082310.1, NM_028034.2 [Q9CWU0-2]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

CORUMiQ9CWU0
STRINGi10090.ENSMUSP00000032701

PTM databases

iPTMnetiQ9CWU0
PhosphoSitePlusiQ9CWU0

Proteomic databases

PaxDbiQ9CWU0
PRIDEiQ9CWU0

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
47944, 41 antibodies

The DNASU plasmid repository

More...
DNASUi
71981

Genome annotation databases

EnsembliENSMUST00000032701; ENSMUSP00000032701; ENSMUSG00000030491 [Q9CWU0-2]
GeneIDi71981
KEGGimmu:71981
UCSCiuc012fij.1, mouse [Q9CWU0-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
91646
MGIiMGI:1919231, Tdrd12

Phylogenomic databases

eggNOGiKOG0331, Eukaryota
GeneTreeiENSGT00940000166448
InParanoidiQ9CWU0
KOiK18409
OrthoDBi231240at2759
PhylomeDBiQ9CWU0
TreeFamiTF332354

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
71981, 0 hits in 22 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Tdrd12, mouse

Protein Ontology

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PROi
PR:Q9CWU0
RNActiQ9CWU0, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000030491, Expressed in oocyte and 69 other tissues
GenevisibleiQ9CWU0, MM

Family and domain databases

Gene3Di2.40.50.90, 2 hits
2.60.40.790, 1 hit
InterProiView protein in InterPro
IPR007052, CS_dom
IPR011545, DEAD/DEAH_box_helicase_dom
IPR008978, HSP20-like_chaperone
IPR027417, P-loop_NTPase
IPR035437, SNase_OB-fold_sf
IPR002999, Tudor
PfamiView protein in Pfam
PF04969, CS, 1 hit
PF00270, DEAD, 1 hit
PF00567, TUDOR, 2 hits
SUPFAMiSSF49764, SSF49764, 1 hit
SSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51203, CS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTDR12_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9CWU0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 4, 2007
Last modified: August 12, 2020
This is version 130 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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