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Protein

Sorting nexin-10

Gene

Snx10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes. Plays a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. Required for the localization to the cilium of V-ATPase subunit ATP6V1D and ATP6V0D1, and RAB8A. Involved in osteoclast differentiation and therefore bone resorption.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei53Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei79Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei94Phosphatidylinositol 3-phosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCilium biogenesis/degradation, Protein transport, Transport
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-10
Gene namesi
Name:Snx10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1919232 Snx10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002138551 – 201Sorting nexin-10Add BLAST201

Proteomic databases

MaxQBiQ9CWT3
PaxDbiQ9CWT3
PRIDEiQ9CWT3

PTM databases

iPTMnetiQ9CWT3
PhosphoSitePlusiQ9CWT3

Expressioni

Tissue specificityi

Expressed in femur, calvariae and teeth.1 Publication

Developmental stagei

Strongly up-regulated during osteoclastogenesis. Expressed in calvariae and developping teeth as early as 16.5 dpc (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000038301 Expressed in 272 organ(s), highest expression level in brown adipose tissue
CleanExiMM_SNX10
ExpressionAtlasiQ9CWT3 baseline and differential
GenevisibleiQ9CWT3 MM

Interactioni

Subunit structurei

Interacts with ATP6V1D; may play a role in ciliogenesis.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044165

Structurei

3D structure databases

ProteinModelPortaliQ9CWT3
SMRiQ9CWT3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 127PXPROSITE-ProRule annotationAdd BLAST118

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni8 – 125Required for interaction with ATP6V1DBy similarityAdd BLAST118

Domaini

The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.By similarity

Sequence similaritiesi

Belongs to the sorting nexin family.Curated

Phylogenomic databases

eggNOGiKOG2527 Eukaryota
COG5391 LUCA
GeneTreeiENSGT00650000093174
HOGENOMiHOG000231108
HOVERGENiHBG054994
InParanoidiQ9CWT3
KOiK17924
OMAiQEFVSVW
OrthoDBiEOG091G0OCQ
PhylomeDBiQ9CWT3
TreeFamiTF332117

Family and domain databases

Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR001683 Phox
IPR036871 PX_dom_sf
IPR039358 Sorting_nexin-like
PANTHERiPTHR10555 PTHR10555, 1 hit
PfamiView protein in Pfam
PF00787 PX, 1 hit
SMARTiView protein in SMART
SM00312 PX, 1 hit
SUPFAMiSSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195 PX, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9CWT3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFPEQQKEEF VSVWVRDPRI QKEDFWHSYI DYEICIHTNS MCFTMKTSCV
60 70 80 90 100
RRRYREFVWL RQRLQSNALL VQLPELPSKN LFFNMNNRQH VDQRRQGLED
110 120 130 140 150
FLRKVLQNAL LLSDSSLHLF LQSHLNSEDI EACVSGQTKY SVEEAIHKFA
160 170 180 190 200
LMNRRFPEEE EEGKKDADVE YDSESSSSGL GHSSDDSSSH GCKTSPALQE

S
Length:201
Mass (Da):23,542
Last modified:June 1, 2001 - v1
Checksum:i34F853BE23D23D80
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YW62D3YW62_MOUSE
Sorting nexin-10
Snx10
177Annotation score:
D3Z4P6D3Z4P6_MOUSE
Sorting nexin-10
Snx10
96Annotation score:
S4R1A0S4R1A0_MOUSE
Sorting nexin-10
Snx10
44Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti168D → E in BAC25786 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010399 mRNA Translation: BAB26910.1
AK028163 mRNA Translation: BAC25786.1
BC010334 mRNA Translation: AAH10334.1
CCDSiCCDS20136.1
RefSeqiNP_001120820.1, NM_001127348.1
NP_001120821.1, NM_001127349.1
NP_082311.3, NM_028035.4
XP_006506716.1, XM_006506653.3
XP_017177242.1, XM_017321753.1
UniGeneiMm.294166

Genome annotation databases

EnsembliENSMUST00000049152; ENSMUSP00000044165; ENSMUSG00000038301
ENSMUST00000114439; ENSMUSP00000110082; ENSMUSG00000038301
ENSMUST00000179365; ENSMUSP00000136974; ENSMUSG00000038301
GeneIDi71982
KEGGimmu:71982
UCSCiuc009bxs.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010399 mRNA Translation: BAB26910.1
AK028163 mRNA Translation: BAC25786.1
BC010334 mRNA Translation: AAH10334.1
CCDSiCCDS20136.1
RefSeqiNP_001120820.1, NM_001127348.1
NP_001120821.1, NM_001127349.1
NP_082311.3, NM_028035.4
XP_006506716.1, XM_006506653.3
XP_017177242.1, XM_017321753.1
UniGeneiMm.294166

3D structure databases

ProteinModelPortaliQ9CWT3
SMRiQ9CWT3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044165

PTM databases

iPTMnetiQ9CWT3
PhosphoSitePlusiQ9CWT3

Proteomic databases

MaxQBiQ9CWT3
PaxDbiQ9CWT3
PRIDEiQ9CWT3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049152; ENSMUSP00000044165; ENSMUSG00000038301
ENSMUST00000114439; ENSMUSP00000110082; ENSMUSG00000038301
ENSMUST00000179365; ENSMUSP00000136974; ENSMUSG00000038301
GeneIDi71982
KEGGimmu:71982
UCSCiuc009bxs.2 mouse

Organism-specific databases

CTDi29887
MGIiMGI:1919232 Snx10

Phylogenomic databases

eggNOGiKOG2527 Eukaryota
COG5391 LUCA
GeneTreeiENSGT00650000093174
HOGENOMiHOG000231108
HOVERGENiHBG054994
InParanoidiQ9CWT3
KOiK17924
OMAiQEFVSVW
OrthoDBiEOG091G0OCQ
PhylomeDBiQ9CWT3
TreeFamiTF332117

Miscellaneous databases

ChiTaRSiSnx10 mouse
PROiPR:Q9CWT3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038301 Expressed in 272 organ(s), highest expression level in brown adipose tissue
CleanExiMM_SNX10
ExpressionAtlasiQ9CWT3 baseline and differential
GenevisibleiQ9CWT3 MM

Family and domain databases

Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR001683 Phox
IPR036871 PX_dom_sf
IPR039358 Sorting_nexin-like
PANTHERiPTHR10555 PTHR10555, 1 hit
PfamiView protein in Pfam
PF00787 PX, 1 hit
SMARTiView protein in SMART
SM00312 PX, 1 hit
SUPFAMiSSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195 PX, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSNX10_MOUSE
AccessioniPrimary (citable) accession number: Q9CWT3
Secondary accession number(s): Q8C1E0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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