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Protein

Integrator complex subunit 11

Gene

Ints11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates the snRNAs 3' cleavage. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex.By similarity

GO - Molecular functioni

GO - Biological processi

  • snRNA 3'-end processing Source: GO_Central
  • snRNA processing Source: BHF-UCL

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

ReactomeiR-MMU-6807505 RNA polymerase II transcribes snRNA genes

Names & Taxonomyi

Protein namesi
Recommended name:
Integrator complex subunit 11 (EC:3.1.27.-)
Short name:
Int11
Alternative name(s):
Cleavage and polyadenylation-specific factor 3-like protein
Short name:
CPSF3-like protein
Gene namesi
Name:Ints11
Synonyms:Cpsf3l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1919207 Ints11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002595641 – 600Integrator complex subunit 11Add BLAST600

Proteomic databases

EPDiQ9CWS4
MaxQBiQ9CWS4
PaxDbiQ9CWS4
PRIDEiQ9CWS4

PTM databases

iPTMnetiQ9CWS4
PhosphoSitePlusiQ9CWS4

Expressioni

Gene expression databases

BgeeiENSMUSG00000029034 Expressed in 267 organ(s), highest expression level in thymus
ExpressionAtlasiQ9CWS4 baseline and differential
GenevisibleiQ9CWS4 MM

Interactioni

Subunit structurei

Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12.By similarity

Protein-protein interaction databases

IntActiQ9CWS4, 1 interactor
MINTiQ9CWS4
STRINGi10090.ENSMUSP00000030901

Structurei

3D structure databases

ProteinModelPortaliQ9CWS4
SMRiQ9CWS4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi68 – 73HXHXDH motif6

Domaini

The HXHXDH motif is essential for the endoribonuclease activity of the CPSF complex.By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1137 Eukaryota
COG1236 LUCA
GeneTreeiENSGT00910000144162
HOGENOMiHOG000231294
HOVERGENiHBG080215
InParanoidiQ9CWS4
KOiK13148
OMAiYLDGMIW
OrthoDBiEOG091G03RH
PhylomeDBiQ9CWS4
TreeFamiTF105878

Family and domain databases

Gene3Di3.60.15.10, 1 hit
InterProiView protein in InterPro
IPR022712 Beta_Casp
IPR001279 Metallo-B-lactamas
IPR036866 RibonucZ/Hydroxyglut_hydro
IPR011108 RMMBL
PfamiView protein in Pfam
PF10996 Beta-Casp, 1 hit
PF16661 Lactamase_B_6, 1 hit
PF07521 RMMBL, 1 hit
SMARTiView protein in SMART
SM01027 Beta-Casp, 1 hit
SM00849 Lactamase_B, 1 hit
SUPFAMiSSF56281 SSF56281, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9CWS4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPEIRVTPLG AGQDVGRSCI LVSISGKNVM LDCGMHMGYN DDRRFPDFSY
60 70 80 90 100
ITQSGRLTDF LDCVIISHFH LDHCGALPYF SEMVGYDGPI YMTHPTQAIC
110 120 130 140 150
PILLEDYRKI AVDKKGEANF FTSQMIKDCM KKVVAVHLHQ TVQVDDELEI
160 170 180 190 200
KAYYAGHVLG AAMFQIKVGS ESVVYTGDYN MTPDRHLGAA WIDKCRPNLL
210 220 230 240 250
ITESTYATTI RDSKRCRERD FLKKVHETVE RGGKVLIPVF ALGRAQELCI
260 270 280 290 300
LLETFWERMN LKVPIYFSTG LTEKANHYYK LFITWTNQKI RKTFVQRNMF
310 320 330 340 350
EFKHIKAFDR TFADNPGPMV VFATPGMLHA GQSLQIFRKW AGNEKNMVIM
360 370 380 390 400
PGYCVQGTVG HKILSGQRKL EMEGRQMLEV KMQVEYMSFS AHADAKGIMQ
410 420 430 440 450
LVGQAEPESV LLVHGEAKKM EFLRQKIEQE FRVSCYMPAN GETVTLPTSP
460 470 480 490 500
SIPVGISLGL LKREMVQGLL PEAKKPRLLH GTLIMKDSNF RLVSSEQALK
510 520 530 540 550
ELGLAEHQLR FTCRVHLQDT RKEQETALRV YSHLKSTLKD HCVQHLPDGS
560 570 580 590 600
VTVESILIQA AAHSEDPGTK VLLVSWTYQD EELGSFLTTL LKNGLPQAPS
Length:600
Mass (Da):67,844
Last modified:June 1, 2001 - v1
Checksum:i1976D09E065BE2FA
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8Y5J3A8Y5J3_MOUSE
Integrator complex subunit 11
Ints11 Cpsf3l
578Annotation score:
D6RH69D6RH69_MOUSE
Integrator complex subunit 11
Ints11 Cpsf3l
94Annotation score:

Sequence cautioni

The sequence AAH08240 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti136V → D in AAH11155 (PubMed:15489334).Curated1
Sequence conflicti297R → G in BAE31460 (PubMed:16141072).Curated1
Sequence conflicti542C → R in BAE39661 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010425 mRNA Translation: BAB26928.1
AK090206 mRNA Translation: BAC41135.1
AK150436 mRNA Translation: BAE29558.1
AK152740 mRNA Translation: BAE31460.1
AK167607 mRNA Translation: BAE39661.1
AK172533 mRNA Translation: BAE43054.1
BC008240 mRNA Translation: AAH08240.1 Different initiation.
BC011155 mRNA Translation: AAH11155.1
CCDSiCCDS19048.1
RefSeqiNP_082296.1, NM_028020.3
XP_006539258.1, XM_006539195.2
UniGeneiMm.475640

Genome annotation databases

EnsembliENSMUST00000030901; ENSMUSP00000030901; ENSMUSG00000029034
GeneIDi71957
KEGGimmu:71957
UCSCiuc008wfh.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010425 mRNA Translation: BAB26928.1
AK090206 mRNA Translation: BAC41135.1
AK150436 mRNA Translation: BAE29558.1
AK152740 mRNA Translation: BAE31460.1
AK167607 mRNA Translation: BAE39661.1
AK172533 mRNA Translation: BAE43054.1
BC008240 mRNA Translation: AAH08240.1 Different initiation.
BC011155 mRNA Translation: AAH11155.1
CCDSiCCDS19048.1
RefSeqiNP_082296.1, NM_028020.3
XP_006539258.1, XM_006539195.2
UniGeneiMm.475640

3D structure databases

ProteinModelPortaliQ9CWS4
SMRiQ9CWS4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9CWS4, 1 interactor
MINTiQ9CWS4
STRINGi10090.ENSMUSP00000030901

PTM databases

iPTMnetiQ9CWS4
PhosphoSitePlusiQ9CWS4

Proteomic databases

EPDiQ9CWS4
MaxQBiQ9CWS4
PaxDbiQ9CWS4
PRIDEiQ9CWS4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030901; ENSMUSP00000030901; ENSMUSG00000029034
GeneIDi71957
KEGGimmu:71957
UCSCiuc008wfh.1 mouse

Organism-specific databases

CTDi54973
MGIiMGI:1919207 Ints11

Phylogenomic databases

eggNOGiKOG1137 Eukaryota
COG1236 LUCA
GeneTreeiENSGT00910000144162
HOGENOMiHOG000231294
HOVERGENiHBG080215
InParanoidiQ9CWS4
KOiK13148
OMAiYLDGMIW
OrthoDBiEOG091G03RH
PhylomeDBiQ9CWS4
TreeFamiTF105878

Enzyme and pathway databases

ReactomeiR-MMU-6807505 RNA polymerase II transcribes snRNA genes

Miscellaneous databases

PROiPR:Q9CWS4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029034 Expressed in 267 organ(s), highest expression level in thymus
ExpressionAtlasiQ9CWS4 baseline and differential
GenevisibleiQ9CWS4 MM

Family and domain databases

Gene3Di3.60.15.10, 1 hit
InterProiView protein in InterPro
IPR022712 Beta_Casp
IPR001279 Metallo-B-lactamas
IPR036866 RibonucZ/Hydroxyglut_hydro
IPR011108 RMMBL
PfamiView protein in Pfam
PF10996 Beta-Casp, 1 hit
PF16661 Lactamase_B_6, 1 hit
PF07521 RMMBL, 1 hit
SMARTiView protein in SMART
SM01027 Beta-Casp, 1 hit
SM00849 Lactamase_B, 1 hit
SUPFAMiSSF56281 SSF56281, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiINT11_MOUSE
AccessioniPrimary (citable) accession number: Q9CWS4
Secondary accession number(s): Q3TJ34
, Q3U7B0, Q91X99, Q922F0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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