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Protein

WD repeat-containing protein 73

Gene

Wdr73

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in the regulation of microtubule organization and dynamics.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 73
Gene namesi
Name:Wdr73
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1919218 Wdr73

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003072811 – 371WD repeat-containing protein 73Add BLAST371

Proteomic databases

EPDiQ9CWR1
PaxDbiQ9CWR1
PeptideAtlasiQ9CWR1
PRIDEiQ9CWR1

PTM databases

PhosphoSitePlusiQ9CWR1

Expressioni

Gene expression databases

BgeeiENSMUSG00000025722 Expressed in 229 organ(s), highest expression level in blastocyst
CleanExiMM_WDR73
ExpressionAtlasiQ9CWR1 baseline and differential
GenevisibleiQ9CWR1 MM

Interactioni

Protein-protein interaction databases

IntActiQ9CWR1, 1 interactor
MINTiQ9CWR1
STRINGi10090.ENSMUSP00000026816

Structurei

3D structure databases

ProteinModelPortaliQ9CWR1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati81 – 121WD 1Add BLAST41
Repeati273 – 313WD 2Add BLAST41
Repeati333 – 371WD 3Add BLAST39

Sequence similaritiesi

Belongs to the WD repeat WDR73 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0264 Eukaryota
ENOG410XNU9 LUCA
GeneTreeiENSGT00390000015701
HOGENOMiHOG000035111
HOVERGENiHBG108672
InParanoidiQ9CWR1
OMAiCKPRTLL
OrthoDBiEOG091G0UM4
TreeFamiTF331370

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR036322 WD40_repeat_dom_sf
SMARTiView protein in SMART
SM00320 WD40, 3 hits
SUPFAMiSSF50978 SSF50978, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9CWR1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MELAEDWLVE SLRLYQDFHA FDLSGATRVL EWIGEKGVFV AGYESLKKNE
60 70 80 90 100
ILHLILPLRL SVQENQGLHP ERDFKVRHGG FSDRSVFDLK HVPDTRLLVT
110 120 130 140 150
SGLPGCYIQM WQVREDNDVI EAVSTIDVQD KEESLWPRVS VFCSKAPGIL
160 170 180 190 200
HGARLSGLRT VDVESQKITY SSGTADSESL SCLQVLDANT FAFCGNSGRL
210 220 230 240 250
GLVDTRQKWA ALETVSPGSG CSGERWCAEV RNKGQGPGPC IASLGSDGQL
260 270 280 290 300
CLLDSRNLCH PVSSAQCPVF KPSPDPELLR VTWAPGLDNC LAISGFDGTV
310 320 330 340 350
QIYDVTSWDG KKTQAEPLFT HKGHIFLDGN DVDSAPLVTT HTWHPRKPRT
360 370
LLSAASDSSL HVWDWVDLQA S
Length:371
Mass (Da):40,856
Last modified:June 1, 2001 - v1
Checksum:i89059680200DA8B7
GO
Isoform 2 (identifier: Q9CWR1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     117-117: N → NAEPGKKHLSQGTAQFLSTTCNQ

Note: No experimental confirmation available.
Show »
Length:393
Mass (Da):43,185
Checksum:iD7B680E63F7A5E99
GO
Isoform 3 (identifier: Q9CWR1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     296-312: FDGTVQIYDVTSWDGKK → TVENVSLHCSLPEAVGA
     313-371: Missing.

Note: No experimental confirmation available.
Show »
Length:312
Mass (Da):34,037
Checksum:i9F3BDD014AA02DBD
GO
Isoform 4 (identifier: Q9CWR1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-109: Missing.
     296-312: FDGTVQIYDVTSWDGKK → TVENVSLHCSLPEAVGA

Note: No experimental confirmation available.
Show »
Length:262
Mass (Da):28,148
Checksum:i8D6BE557BFE87560
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6RXX6F6RXX6_MOUSE
WD repeat-containing protein 73
Wdr73
240Annotation score:

Sequence cautioni

The sequence AAH28870 differs from that shown. Reason: Frameshift at position 49.Curated
The sequence BAD90132 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti91H → R in BAE41211 (PubMed:16141072).Curated1
Sequence conflicti221C → S in BAD90132 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0286671 – 109Missing in isoform 4. 1 PublicationAdd BLAST109
Alternative sequenceiVSP_028668117N → NAEPGKKHLSQGTAQFLSTT CNQ in isoform 2. 1 Publication1
Alternative sequenceiVSP_028669296 – 312FDGTV…WDGKK → TVENVSLHCSLPEAVGA in isoform 3 and isoform 4. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_028670313 – 371Missing in isoform 3. 1 PublicationAdd BLAST59

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004708 mRNA Translation: BAC25093.1
AK010448 mRNA Translation: BAB26948.1
AK034740 mRNA Translation: BAC28814.1
AK049132 mRNA Translation: BAC33560.1
AK169527 mRNA Translation: BAE41211.1
AK220207 mRNA Translation: BAD90132.1 Different initiation.
BC028870 mRNA Translation: AAH28870.1 Frameshift.
BC087940 mRNA Translation: AAH87940.1
CCDSiCCDS52282.1 [Q9CWR1-1]
RefSeqiNP_082302.2, NM_028026.2 [Q9CWR1-1]
XP_006541269.1, XM_006541206.1
XP_006541270.1, XM_006541207.3
XP_006541271.1, XM_006541208.2
XP_006541272.1, XM_006541209.1
XP_011249206.1, XM_011250904.1
UniGeneiMm.274226

Genome annotation databases

EnsembliENSMUST00000026816; ENSMUSP00000026816; ENSMUSG00000025722 [Q9CWR1-1]
GeneIDi71968
KEGGimmu:71968
UCSCiuc009ibj.2 mouse [Q9CWR1-3]
uc009ibk.2 mouse [Q9CWR1-1]
uc033jae.1 mouse [Q9CWR1-4]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004708 mRNA Translation: BAC25093.1
AK010448 mRNA Translation: BAB26948.1
AK034740 mRNA Translation: BAC28814.1
AK049132 mRNA Translation: BAC33560.1
AK169527 mRNA Translation: BAE41211.1
AK220207 mRNA Translation: BAD90132.1 Different initiation.
BC028870 mRNA Translation: AAH28870.1 Frameshift.
BC087940 mRNA Translation: AAH87940.1
CCDSiCCDS52282.1 [Q9CWR1-1]
RefSeqiNP_082302.2, NM_028026.2 [Q9CWR1-1]
XP_006541269.1, XM_006541206.1
XP_006541270.1, XM_006541207.3
XP_006541271.1, XM_006541208.2
XP_006541272.1, XM_006541209.1
XP_011249206.1, XM_011250904.1
UniGeneiMm.274226

3D structure databases

ProteinModelPortaliQ9CWR1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9CWR1, 1 interactor
MINTiQ9CWR1
STRINGi10090.ENSMUSP00000026816

PTM databases

PhosphoSitePlusiQ9CWR1

Proteomic databases

EPDiQ9CWR1
PaxDbiQ9CWR1
PeptideAtlasiQ9CWR1
PRIDEiQ9CWR1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026816; ENSMUSP00000026816; ENSMUSG00000025722 [Q9CWR1-1]
GeneIDi71968
KEGGimmu:71968
UCSCiuc009ibj.2 mouse [Q9CWR1-3]
uc009ibk.2 mouse [Q9CWR1-1]
uc033jae.1 mouse [Q9CWR1-4]

Organism-specific databases

CTDi84942
MGIiMGI:1919218 Wdr73

Phylogenomic databases

eggNOGiKOG0264 Eukaryota
ENOG410XNU9 LUCA
GeneTreeiENSGT00390000015701
HOGENOMiHOG000035111
HOVERGENiHBG108672
InParanoidiQ9CWR1
OMAiCKPRTLL
OrthoDBiEOG091G0UM4
TreeFamiTF331370

Miscellaneous databases

PROiPR:Q9CWR1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025722 Expressed in 229 organ(s), highest expression level in blastocyst
CleanExiMM_WDR73
ExpressionAtlasiQ9CWR1 baseline and differential
GenevisibleiQ9CWR1 MM

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR036322 WD40_repeat_dom_sf
SMARTiView protein in SMART
SM00320 WD40, 3 hits
SUPFAMiSSF50978 SSF50978, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiWDR73_MOUSE
AccessioniPrimary (citable) accession number: Q9CWR1
Secondary accession number(s): Q05C70
, Q3TEN7, Q571I2, Q8BSB9, Q8CF62
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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