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Protein

Zinc finger SWIM domain-containing protein 7

Gene

Zswim7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in early stages of the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri76 – 114SWIM-typePROSITE-ProRule annotationAdd BLAST39

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA recombination, DNA repair
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger SWIM domain-containing protein 7
Alternative name(s):
SWIM domain-containing and Srs2-interacting protein 1 homolog
Gene namesi
Name:Zswim7
Synonyms:Sws1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1916997 Zswim7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003074041 – 152Zinc finger SWIM domain-containing protein 7Add BLAST152

Proteomic databases

MaxQBiQ9CWQ2
PaxDbiQ9CWQ2
PRIDEiQ9CWQ2

PTM databases

PhosphoSitePlusiQ9CWQ2

Expressioni

Gene expression databases

BgeeiENSMUSG00000014243
GenevisibleiQ9CWQ2 MM

Interactioni

Subunit structurei

Interacts with RAD51D and XRCC3; involved in homologous recombination repair. Interacts with SWSAP1; they form a functional complex involved in homologous recombination repair and stabilize each other (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000072688

Family & Domainsi

Sequence similaritiesi

Belongs to the SWS1 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri76 – 114SWIM-typePROSITE-ProRule annotationAdd BLAST39

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IWUY Eukaryota
ENOG4112D11 LUCA
GeneTreeiENSGT00390000017523
HOGENOMiHOG000006441
HOVERGENiHBG105170
InParanoidiQ9CWQ2
OMAiLKFVFGS
OrthoDBiEOG091G0SHF
PhylomeDBiQ9CWQ2
TreeFamiTF339438

Family and domain databases

InterProiView protein in InterPro
IPR007527 Znf_SWIM
PfamiView protein in Pfam
PF04434 SWIM, 1 hit
PROSITEiView protein in PROSITE
PS50966 ZF_SWIM, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CWQ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVALPEVVE ELLSEMAAAV RDSARIPDEL LLSLEFVFGS SAIQALDLVD
60 70 80 90 100
RESVTLISSP SGRRVYQVLG SSGKTYTCLA SCHYCSCPAF SFSVLRKSDS
110 120 130 140 150
LLCKHLLAIY LSQLLRNCQQ LHVSDKQLTD LLMEDTRRIK GAAGTWTSKT

EA
Length:152
Mass (Da):16,658
Last modified:June 1, 2001 - v1
Checksum:iEAF097B3BDA0495D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010472 mRNA Translation: BAB26965.1
AL596110 Genomic DNA No translation available.
BC109343 mRNA Translation: AAI09344.1
CCDSiCCDS48816.1
RefSeqiNP_081474.1, NM_027198.1
UniGeneiMm.141150

Genome annotation databases

EnsembliENSMUST00000072916; ENSMUSP00000072688; ENSMUSG00000014243
GeneIDi69747
KEGGimmu:69747
UCSCiuc007jip.2 mouse

Similar proteinsi

Entry informationi

Entry nameiZSWM7_MOUSE
AccessioniPrimary (citable) accession number: Q9CWQ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: June 1, 2001
Last modified: January 31, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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