Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Prefoldin subunit 1

Gene

Pfdn1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • actin cytoskeleton organization Source: MGI
  • B cell activation Source: MGI
  • cerebellum development Source: MGI
  • telencephalon development Source: MGI

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Prefoldin subunit 1
Gene namesi
Name:Pfdn1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1914449 Pfdn1

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001248312 – 122Prefoldin subunit 1Add BLAST121

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9CWM4
MaxQBiQ9CWM4
PaxDbiQ9CWM4
PRIDEiQ9CWM4

2D gel databases

REPRODUCTION-2DPAGEiQ9CWM4

PTM databases

iPTMnetiQ9CWM4
PhosphoSitePlusiQ9CWM4

Expressioni

Gene expression databases

CleanExiMM_PFDN1

Interactioni

Subunit structurei

Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9CWM4, 2 interactors
MINTiQ9CWM4
STRINGi10090.ENSMUSP00000025204

Structurei

3D structure databases

ProteinModelPortaliQ9CWM4
SMRiQ9CWM4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the prefoldin subunit beta family.Curated

Phylogenomic databases

eggNOGiENOG410ISJS Eukaryota
ENOG4111Q46 LUCA
HOGENOMiHOG000005946
HOVERGENiHBG031813
InParanoidiQ9CWM4
PhylomeDBiQ9CWM4

Family and domain databases

Gene3Di1.10.287.370, 1 hit
InterProiView protein in InterPro
IPR002777 PFD_beta-like
IPR009053 Prefoldin
PfamiView protein in Pfam
PF01920 Prefoldin_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9CWM4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAASVDLELK KAFTELQAKV IDTQQKVKLA DIQIEQLNRT KKHAHLTDTE
60 70 80 90 100
IMTLVDETNM YEGVGRMFIL QSKEVIHNQL LEKQKIAKEK IKELEQKKSY
110 120
LERSVKEAED NIREMLMARR AQ
Length:122
Mass (Da):14,255
Last modified:June 1, 2001 - v1
Checksum:i923EEB94802C6664
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9CQF7Q9CQF7_MOUSE
Prefoldin 1
Pfdn1 mCG_121970
122Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010532 mRNA Translation: BAB27010.1
CCDSiCCDS29152.1
UniGeneiMm.30184

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010532 mRNA Translation: BAB27010.1
CCDSiCCDS29152.1
UniGeneiMm.30184

3D structure databases

ProteinModelPortaliQ9CWM4
SMRiQ9CWM4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9CWM4, 2 interactors
MINTiQ9CWM4
STRINGi10090.ENSMUSP00000025204

PTM databases

iPTMnetiQ9CWM4
PhosphoSitePlusiQ9CWM4

2D gel databases

REPRODUCTION-2DPAGEiQ9CWM4

Proteomic databases

EPDiQ9CWM4
MaxQBiQ9CWM4
PaxDbiQ9CWM4
PRIDEiQ9CWM4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1914449 Pfdn1

Phylogenomic databases

eggNOGiENOG410ISJS Eukaryota
ENOG4111Q46 LUCA
HOGENOMiHOG000005946
HOVERGENiHBG031813
InParanoidiQ9CWM4
PhylomeDBiQ9CWM4

Miscellaneous databases

PROiPR:Q9CWM4
SOURCEiSearch...

Gene expression databases

CleanExiMM_PFDN1

Family and domain databases

Gene3Di1.10.287.370, 1 hit
InterProiView protein in InterPro
IPR002777 PFD_beta-like
IPR009053 Prefoldin
PfamiView protein in Pfam
PF01920 Prefoldin_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPFD1_MOUSE
AccessioniPrimary (citable) accession number: Q9CWM4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 2002
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again