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Protein

Beta-catenin-like protein 1

Gene

Ctnnbl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May induce apoptosis (By similarity). Participates in AID/AICDA-mediated Ig class switching recombination (CSR).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis

Enzyme and pathway databases

ReactomeiR-MMU-72163 mRNA Splicing - Major Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-catenin-like protein 1
Alternative name(s):
Nuclear-associated protein
Short name:
NAP
Gene namesi
Name:Ctnnbl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1913892 Ctnnbl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000794911 – 563Beta-catenin-like protein 1Add BLAST563

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei91N6-acetyllysineBy similarity1
Modified residuei389PhosphoserineBy similarity1
Modified residuei545PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9CWL8
MaxQBiQ9CWL8
PaxDbiQ9CWL8
PeptideAtlasiQ9CWL8
PRIDEiQ9CWL8

PTM databases

iPTMnetiQ9CWL8
PhosphoSitePlusiQ9CWL8

Expressioni

Gene expression databases

BgeeiENSMUSG00000027649 Expressed in 269 organ(s), highest expression level in primary oocyte
CleanExiMM_CTNNBL1
GenevisibleiQ9CWL8 MM

Interactioni

Subunit structurei

Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8. Interacts directly with CWC15 and CDC5L in the complex. Interacts with AICDA; the interaction is important for the antibody diversification activity of AICDA. Interacts with PRPF31 (via its NLS). Interacts (via its N-terminal NLS) with KPNA1 and KPNA2 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211616, 12 interactors
IntActiQ9CWL8, 14 interactors
MINTiQ9CWL8
STRINGi10090.ENSMUSP00000029178

Structurei

3D structure databases

ProteinModelPortaliQ9CWL8
SMRiQ9CWL8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati79 – 129HEAT 1Add BLAST51
Repeati134 – 176HEAT 2Add BLAST43
Repeati178 – 228ARM 1Add BLAST51
Repeati229 – 273ARM 2Add BLAST45
Repeati274 – 323ARM 3Add BLAST50
Repeati325 – 363ARM 4Add BLAST39
Repeati364 – 417ARM 5Add BLAST54

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili476 – 540By similarityAdd BLAST65

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi16 – 33Nuclear localization signalBy similarityAdd BLAST18
Motifi130 – 140Nuclear export signal (NES)By similarityAdd BLAST11

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi22 – 25Poly-Glu4
Compositional biasi68 – 75Poly-Glu8

Domaini

The surface residues of the concave side of the superhelical ARM repeat region contribute to, but are not essential for NLS binding.By similarity

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG2734 Eukaryota
ENOG410XPFW LUCA
GeneTreeiENSGT00390000006931
HOGENOMiHOG000186529
HOVERGENiHBG051212
InParanoidiQ9CWL8
KOiK12864
OMAiASMLRNC
OrthoDBiEOG091G05SE
PhylomeDBiQ9CWL8
TreeFamiTF314294

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR039678 CTNNBL1
IPR013180 CTNNBL1_N
PANTHERiPTHR14978 PTHR14978, 1 hit
PfamiView protein in Pfam
PF08216 CTNNBL, 1 hit
SMARTiView protein in SMART
SM01156 DUF1716, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CWL8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDVGELLSYQ PNRGTKRPRD DEEEELKTRR KQTGPRERGR YREEEATAAE
60 70 80 90 100
DTADDKKRLL QIIDRDGEEE EEEEEPLDES SVKKMILTFE KRSYKNQELR
110 120 130 140 150
IKFPDNPEKF MESELDLNDI IQEMHVVATM PDLYHLLVEL SAVQSLLGLL
160 170 180 190 200
GHDNTDVSIA VVDLLQELTD IDTLHESEEG AEVLIDALVD GQVAALLVQN
210 220 230 240 250
LERLDESVRE EADGVHNTLA IVENMAEFRP EMCTEAAQQG LLQWLLKRLK
260 270 280 290 300
AKMPFDANKL YCSEVLAILL QDNDENRELL GELDGIDVLL QQLSVFKRHN
310 320 330 340 350
PSTAEEQEMM ENLFDALCSC LMLSSNRERF LKGEGLQLMN LMLREKKVSR
360 370 380 390 400
SSALKVLDHA MIGPEGTDNC HKFVDILGLR TIFPLFMKSP RKIKKVGTTE
410 420 430 440 450
KEHEEHVCSI LASLLRNLRG QQRTRLLNKF TENDSEKVDR LMELHFKYLS
460 470 480 490 500
AMQVADKKIE GEKHDIVRRG EIIDNDMEDE FYLRRLDAGL FILQHICYIM
510 520 530 540 550
AEICNANVPQ IRQRVHQILN MRGSSIKIVR HIIKEYAENI GDGRSPEFRE
560
TEQKRILALL ENF
Length:563
Mass (Da):64,980
Last modified:June 1, 2001 - v1
Checksum:i89B67CF3A379C3D2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti121I → V in BAC32034 (PubMed:16141072).Curated1
Sequence conflicti148G → C in AAH50787 (PubMed:15489334).Curated1
Sequence conflicti399 – 400TE → QQ in AAK27389 (PubMed:12659813).Curated2
Sequence conflicti418L → M in BAC36902 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY009405 mRNA Translation: AAK27389.1
AK010547 mRNA Translation: BAB27020.1
AK044690 mRNA Translation: BAC32034.1
AK077616 mRNA Translation: BAC36902.1
AK145598 mRNA Translation: BAE26532.1
AK145719 mRNA Translation: BAE26609.1
BC050787 mRNA Translation: AAH50787.1
CCDSiCCDS16982.1
RefSeqiNP_079956.3, NM_025680.4
UniGeneiMm.45193

Genome annotation databases

EnsembliENSMUST00000029178; ENSMUSP00000029178; ENSMUSG00000027649
GeneIDi66642
KEGGimmu:66642
UCSCiuc008nph.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY009405 mRNA Translation: AAK27389.1
AK010547 mRNA Translation: BAB27020.1
AK044690 mRNA Translation: BAC32034.1
AK077616 mRNA Translation: BAC36902.1
AK145598 mRNA Translation: BAE26532.1
AK145719 mRNA Translation: BAE26609.1
BC050787 mRNA Translation: AAH50787.1
CCDSiCCDS16982.1
RefSeqiNP_079956.3, NM_025680.4
UniGeneiMm.45193

3D structure databases

ProteinModelPortaliQ9CWL8
SMRiQ9CWL8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211616, 12 interactors
IntActiQ9CWL8, 14 interactors
MINTiQ9CWL8
STRINGi10090.ENSMUSP00000029178

PTM databases

iPTMnetiQ9CWL8
PhosphoSitePlusiQ9CWL8

Proteomic databases

EPDiQ9CWL8
MaxQBiQ9CWL8
PaxDbiQ9CWL8
PeptideAtlasiQ9CWL8
PRIDEiQ9CWL8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029178; ENSMUSP00000029178; ENSMUSG00000027649
GeneIDi66642
KEGGimmu:66642
UCSCiuc008nph.2 mouse

Organism-specific databases

CTDi56259
MGIiMGI:1913892 Ctnnbl1

Phylogenomic databases

eggNOGiKOG2734 Eukaryota
ENOG410XPFW LUCA
GeneTreeiENSGT00390000006931
HOGENOMiHOG000186529
HOVERGENiHBG051212
InParanoidiQ9CWL8
KOiK12864
OMAiASMLRNC
OrthoDBiEOG091G05SE
PhylomeDBiQ9CWL8
TreeFamiTF314294

Enzyme and pathway databases

ReactomeiR-MMU-72163 mRNA Splicing - Major Pathway

Miscellaneous databases

PROiPR:Q9CWL8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027649 Expressed in 269 organ(s), highest expression level in primary oocyte
CleanExiMM_CTNNBL1
GenevisibleiQ9CWL8 MM

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR039678 CTNNBL1
IPR013180 CTNNBL1_N
PANTHERiPTHR14978 PTHR14978, 1 hit
PfamiView protein in Pfam
PF08216 CTNNBL, 1 hit
SMARTiView protein in SMART
SM01156 DUF1716, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCTBL1_MOUSE
AccessioniPrimary (citable) accession number: Q9CWL8
Secondary accession number(s): Q3UL41, Q80X64, Q8VHE3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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