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Protein

CD2 antigen cytoplasmic tail-binding protein 2

Gene

Cd2bp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-MMU-72163 mRNA Splicing - Major Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
CD2 antigen cytoplasmic tail-binding protein 2
Short name:
CD2 cytoplasmic domain-binding protein 2
Short name:
CD2 tail-binding protein 2
Gene namesi
Name:Cd2bp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1917483 Cd2bp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000894381 – 342CD2 antigen cytoplasmic tail-binding protein 2Add BLAST342

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki26Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei44N6-acetyllysineCombined sources1
Modified residuei46PhosphoserineBy similarity1
Modified residuei49PhosphoserineCombined sources1
Modified residuei117PhosphoserineBy similarity1
Modified residuei196PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9CWK3
MaxQBiQ9CWK3
PaxDbiQ9CWK3
PRIDEiQ9CWK3

PTM databases

iPTMnetiQ9CWK3
PhosphoSitePlusiQ9CWK3

Expressioni

Gene expression databases

BgeeiENSMUSG00000042502 Expressed in 271 organ(s), highest expression level in ear vesicle
CleanExiMM_CD2BP2
ExpressionAtlasiQ9CWK3 baseline and differential
GenevisibleiQ9CWK3 MM

Interactioni

Subunit structurei

Component of the U5 snRNP complex composed of the U5 snRNA and at least PRPF6, PRPF8, SNRNP200, EFTUD2, SNRNP40, DDX23, TXNL4A and CD2BP2. Interacts directly with TXNL4A and PRPF6. Interacts (via GYF domain) with CD2 (via Pro-rich sequence in the cytoplasmic domain). Interacts with PQBP1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi213930, 1 interactor
IntActiQ9CWK3, 1 interactor
MINTiQ9CWK3
STRINGi10090.ENSMUSP00000044790

Structurei

3D structure databases

ProteinModelPortaliQ9CWK3
SMRiQ9CWK3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini281 – 339GYFPROSITE-ProRule annotationAdd BLAST59

Phylogenomic databases

eggNOGiKOG2950 Eukaryota
ENOG4111KF5 LUCA
GeneTreeiENSGT00390000012483
HOVERGENiHBG056920
InParanoidiQ9CWK3
KOiK13099
OMAiDGHYHWN
OrthoDBiEOG091G0MVR
PhylomeDBiQ9CWK3
TreeFamiTF313042

Family and domain databases

CDDicd00072 GYF, 1 hit
Gene3Di3.30.1490.40, 1 hit
InterProiView protein in InterPro
IPR039905 CD2BP2/Lin1
IPR003169 GYF
IPR035445 GYF-like_dom_sf
PANTHERiPTHR13138 PTHR13138, 1 hit
PfamiView protein in Pfam
PF02213 GYF, 1 hit
SMARTiView protein in SMART
SM00444 GYF, 1 hit
SUPFAMiSSF55277 SSF55277, 1 hit
PROSITEiView protein in PROSITE
PS50829 GYF, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9CWK3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPKRKVTFQG VGDEDGEDEI SVPKKKLVDP VAAAGGPGSR FKGKHSLDSD
60 70 80 90 100
EEDDDEEGSS KYDILASEDV EGQEAATLPS EGGVRITPFN LQEEMEEGHF
110 120 130 140 150
DADGNYFLNQ DAQIRDSWLD NIDWVRIKER PPDKHQVSDS EEEDSLGQTP
160 170 180 190 200
MSAQALLEGL LELLLPRETV AGALRRLGAR GGGKGSNSKG TGRPNSPQRL
210 220 230 240 250
DRLSGLADQM VARGNLGVYQ ETRERLAMRL KGLGCRAQGS HDPTPPPSLD
260 270 280 290 300
MFAEEVAEGE LETPTPTQRE EAESAGDGLM DVMWEYKWEN TGDAELYGPF
310 320 330 340
TSAQMQTWVS EGYFPDGVYC RKLDPPGGQF YNSKRIDFEL YT
Length:342
Mass (Da):37,694
Last modified:June 1, 2001 - v1
Checksum:i6B00FBE777A19206
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0U1RNG1A0A0U1RNG1_MOUSE
CD2 antigen cytoplasmic tail-bindin...
Cd2bp2
162Annotation score:
A0A0U1RP07A0A0U1RP07_MOUSE
CD2 antigen cytoplasmic tail-bindin...
Cd2bp2
130Annotation score:
A0A0U1RPR4A0A0U1RPR4_MOUSE
CD2 antigen cytoplasmic tail-bindin...
Cd2bp2
48Annotation score:
A0A0U1RNN2A0A0U1RNN2_MOUSE
CD2 antigen cytoplasmic tail-bindin...
Cd2bp2
79Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC006920 mRNA Translation: AAH06920.1
AK010582 mRNA Translation: BAB27044.1
AK030393 mRNA Translation: BAC26940.1
AK031694 mRNA Translation: BAC27518.1
AK034689 mRNA Translation: BAC28798.1
AK167249 mRNA Translation: BAE39370.1
CCDSiCCDS21859.1
RefSeqiNP_001272834.1, NM_001285905.1
NP_001272835.1, NM_001285906.1
NP_001272836.1, NM_001285907.1
NP_081629.1, NM_027353.4
XP_006508260.1, XM_006508197.2
XP_006508261.1, XM_006508198.3
UniGeneiMm.28050

Genome annotation databases

EnsembliENSMUST00000035771; ENSMUSP00000044790; ENSMUSG00000042502
ENSMUST00000166791; ENSMUSP00000132963; ENSMUSG00000042502
ENSMUST00000205316; ENSMUSP00000145888; ENSMUSG00000042502
ENSMUST00000206026; ENSMUSP00000146167; ENSMUSG00000042502
GeneIDi70233
KEGGimmu:70233
UCSCiuc009juj.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC006920 mRNA Translation: AAH06920.1
AK010582 mRNA Translation: BAB27044.1
AK030393 mRNA Translation: BAC26940.1
AK031694 mRNA Translation: BAC27518.1
AK034689 mRNA Translation: BAC28798.1
AK167249 mRNA Translation: BAE39370.1
CCDSiCCDS21859.1
RefSeqiNP_001272834.1, NM_001285905.1
NP_001272835.1, NM_001285906.1
NP_001272836.1, NM_001285907.1
NP_081629.1, NM_027353.4
XP_006508260.1, XM_006508197.2
XP_006508261.1, XM_006508198.3
UniGeneiMm.28050

3D structure databases

ProteinModelPortaliQ9CWK3
SMRiQ9CWK3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi213930, 1 interactor
IntActiQ9CWK3, 1 interactor
MINTiQ9CWK3
STRINGi10090.ENSMUSP00000044790

PTM databases

iPTMnetiQ9CWK3
PhosphoSitePlusiQ9CWK3

Proteomic databases

EPDiQ9CWK3
MaxQBiQ9CWK3
PaxDbiQ9CWK3
PRIDEiQ9CWK3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035771; ENSMUSP00000044790; ENSMUSG00000042502
ENSMUST00000166791; ENSMUSP00000132963; ENSMUSG00000042502
ENSMUST00000205316; ENSMUSP00000145888; ENSMUSG00000042502
ENSMUST00000206026; ENSMUSP00000146167; ENSMUSG00000042502
GeneIDi70233
KEGGimmu:70233
UCSCiuc009juj.2 mouse

Organism-specific databases

CTDi10421
MGIiMGI:1917483 Cd2bp2

Phylogenomic databases

eggNOGiKOG2950 Eukaryota
ENOG4111KF5 LUCA
GeneTreeiENSGT00390000012483
HOVERGENiHBG056920
InParanoidiQ9CWK3
KOiK13099
OMAiDGHYHWN
OrthoDBiEOG091G0MVR
PhylomeDBiQ9CWK3
TreeFamiTF313042

Enzyme and pathway databases

ReactomeiR-MMU-72163 mRNA Splicing - Major Pathway

Miscellaneous databases

PROiPR:Q9CWK3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042502 Expressed in 271 organ(s), highest expression level in ear vesicle
CleanExiMM_CD2BP2
ExpressionAtlasiQ9CWK3 baseline and differential
GenevisibleiQ9CWK3 MM

Family and domain databases

CDDicd00072 GYF, 1 hit
Gene3Di3.30.1490.40, 1 hit
InterProiView protein in InterPro
IPR039905 CD2BP2/Lin1
IPR003169 GYF
IPR035445 GYF-like_dom_sf
PANTHERiPTHR13138 PTHR13138, 1 hit
PfamiView protein in Pfam
PF02213 GYF, 1 hit
SMARTiView protein in SMART
SM00444 GYF, 1 hit
SUPFAMiSSF55277 SSF55277, 1 hit
PROSITEiView protein in PROSITE
PS50829 GYF, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCD2B2_MOUSE
AccessioniPrimary (citable) accession number: Q9CWK3
Secondary accession number(s): Q3TJX5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2003
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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