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Protein

BRCA2 and CDKN1A-interacting protein

Gene

Bccip

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

During interphase, required for microtubule organizing and anchoring activities. During mitosis, required for the organization and stabilization of the spindle pole (PubMed:28394342). May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ) (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, DNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
BRCA2 and CDKN1A-interacting protein
Gene namesi
Name:Bccip
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1913415 Bccip

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002496881 – 316BRCA2 and CDKN1A-interacting proteinAdd BLAST316

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei44PhosphoserineBy similarity1
Modified residuei114PhosphoserineBy similarity1
Modified residuei283PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9CWI3
MaxQBiQ9CWI3
PaxDbiQ9CWI3
PeptideAtlasiQ9CWI3
PRIDEiQ9CWI3

PTM databases

iPTMnetiQ9CWI3
PhosphoSitePlusiQ9CWI3

Expressioni

Gene expression databases

BgeeiENSMUSG00000030983 Expressed in 274 organ(s), highest expression level in membranous labyrinth
CleanExiMM_BCCIP
GenevisibleiQ9CWI3 MM

Interactioni

Subunit structurei

Interacts with BRCA2, CDKN1A and MTDH/LYRIC. Interacts with DCTN1/p150-glued and ACTR1A/ARP1. Interacts with alpha-, beta- and gamma-tubulins. Interacts with TENT5C; the interaction has no effect on TENT5C poly(A) polymerase function (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9CWI3, 1 interactor
MINTiQ9CWI3
STRINGi10090.ENSMUSP00000033282

Structurei

3D structure databases

ProteinModelPortaliQ9CWI3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni61 – 169Interaction with BRCA2By similarityAdd BLAST109
Regioni163 – 261Interaction with CDKN1ABy similarityAdd BLAST99

Sequence similaritiesi

Belongs to the BCP1 family.Curated

Phylogenomic databases

eggNOGiKOG3034 Eukaryota
ENOG4111GYV LUCA
GeneTreeiENSGT00390000000696
HOGENOMiHOG000047210
HOVERGENiHBG054955
InParanoidiQ9CWI3
KOiK15262
OMAiGSVICQC
OrthoDBiEOG091G0IXA
PhylomeDBiQ9CWI3
TreeFamiTF320301

Family and domain databases

InterProiView protein in InterPro
IPR025602 BCP1_family
PANTHERiPTHR13261 PTHR13261, 1 hit
PfamiView protein in Pfam
PF13862 BCIP, 1 hit
PIRSFiPIRSF028983 BCP1, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CWI3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASKAKKRAV GNGIQRPLGA PGQREEEEEE EDEVEDEEED EDDSDEEEDE
60 70 80 90 100
VDEIVDEEVN IEFEAYSISD NDYGGIKKLL QQLFLKAPVN TAELTNLLMQ
110 120 130 140 150
QNHIGSVIKQ TDVSEDSDDE VDEDEIFGFI SLLNLTERKG TQCAEQIKEL
160 170 180 190 200
VLSFCEKTCE QSMVEQLDKL LNDTSKPVGL LLSERFINVP PQIALPMHQQ
210 220 230 240 250
LQKELSEARR TNKPCGKCCF YLLISKTFME AGKSSSRKRQ DSLQQGALMF
260 270 280 290 300
ANAEEEFFYE KAILKFSYSV QGESDTRLGG RWSFDDVPMT PLRTVMVIPD
310
DRMNEIMETL KDHLSV
Length:316
Mass (Da):35,942
Last modified:June 1, 2001 - v1
Checksum:i49E59C1AF93A149B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti83L → P in BAB22925 (PubMed:16141072).Curated1
Sequence conflicti301D → G in BAB22925 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003666 mRNA Translation: BAB22925.1
AK010684 mRNA Translation: BAB27116.1
BC048465 mRNA Translation: AAH48465.1
CCDSiCCDS21935.1
RefSeqiNP_079668.2, NM_025392.2
UniGeneiMm.389983

Genome annotation databases

EnsembliENSMUST00000033282; ENSMUSP00000033282; ENSMUSG00000030983
GeneIDi66165
KEGGimmu:66165
UCSCiuc009kdi.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003666 mRNA Translation: BAB22925.1
AK010684 mRNA Translation: BAB27116.1
BC048465 mRNA Translation: AAH48465.1
CCDSiCCDS21935.1
RefSeqiNP_079668.2, NM_025392.2
UniGeneiMm.389983

3D structure databases

ProteinModelPortaliQ9CWI3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9CWI3, 1 interactor
MINTiQ9CWI3
STRINGi10090.ENSMUSP00000033282

PTM databases

iPTMnetiQ9CWI3
PhosphoSitePlusiQ9CWI3

Proteomic databases

EPDiQ9CWI3
MaxQBiQ9CWI3
PaxDbiQ9CWI3
PeptideAtlasiQ9CWI3
PRIDEiQ9CWI3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033282; ENSMUSP00000033282; ENSMUSG00000030983
GeneIDi66165
KEGGimmu:66165
UCSCiuc009kdi.1 mouse

Organism-specific databases

CTDi56647
MGIiMGI:1913415 Bccip

Phylogenomic databases

eggNOGiKOG3034 Eukaryota
ENOG4111GYV LUCA
GeneTreeiENSGT00390000000696
HOGENOMiHOG000047210
HOVERGENiHBG054955
InParanoidiQ9CWI3
KOiK15262
OMAiGSVICQC
OrthoDBiEOG091G0IXA
PhylomeDBiQ9CWI3
TreeFamiTF320301

Miscellaneous databases

ChiTaRSiBccip mouse
PROiPR:Q9CWI3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030983 Expressed in 274 organ(s), highest expression level in membranous labyrinth
CleanExiMM_BCCIP
GenevisibleiQ9CWI3 MM

Family and domain databases

InterProiView protein in InterPro
IPR025602 BCP1_family
PANTHERiPTHR13261 PTHR13261, 1 hit
PfamiView protein in Pfam
PF13862 BCIP, 1 hit
PIRSFiPIRSF028983 BCP1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBCCIP_MOUSE
AccessioniPrimary (citable) accession number: Q9CWI3
Secondary accession number(s): Q9D1E0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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