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Protein

Biogenesis of lysosome-related organelles complex 1 subunit 2

Gene

Bloc1s2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes (By similarity). In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (PubMed:16760431, PubMed:21998198). The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension (PubMed:19546860). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (By similarity).By similarity3 Publications

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Biogenesis of lysosome-related organelles complex 1 subunit 2
Short name:
BLOC-1 subunit 2
Gene namesi
Name:Bloc1s2
Synonyms:Blos2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1920939 Bloc1s2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002345452 – 143Biogenesis of lysosome-related organelles complex 1 subunit 2Add BLAST142

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9CWG9
MaxQBiQ9CWG9
PaxDbiQ9CWG9
PeptideAtlasiQ9CWG9
PRIDEiQ9CWG9

PTM databases

iPTMnetiQ9CWG9
PhosphoSitePlusiQ9CWG9

Expressioni

Gene expression databases

BgeeiENSMUSG00000057506 Expressed in 19 organ(s), highest expression level in spleen
GenevisibleiQ9CWG9 MM

Interactioni

Subunit structurei

Component of the biogenesis of lysosome-related organelles complex 1 (BLOC-1) composed of BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. Octamer composed of one copy each BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. Interacts directly with BLOC1S1, BLOC1S3, BLOC1S4, BLOC1S5 and SNAPIN (PubMed:15102850). The BLOC-1 complex associates with the AP-3 protein complex and membrane protein cargos (PubMed:21998198). Component of the BLOC-one-related complex (BORC) which is composed of BLOC1S1, BLOC1S2, BORCS5, BORCS6, BORCS7, BORCS8, KXD1 and SNAPIN (By similarity). Interacts with gamma-tubulin (By similarity). Interacts with IFT57 (PubMed:18188704).By similarity3 Publications

GO - Molecular functioni

Protein-protein interaction databases

ComplexPortaliCPX-1913 BLOC-1 complex
CORUMiQ9CWG9
STRINGi10090.ENSMUSP00000078042

Structurei

3D structure databases

ProteinModelPortaliQ9CWG9
SMRiQ9CWG9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili80 – 128Sequence analysisAdd BLAST49

Sequence similaritiesi

Belongs to the BLOC1S2 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4559 Eukaryota
ENOG4111XFP LUCA
GeneTreeiENSGT00390000005889
HOGENOMiHOG000111279
HOVERGENiHBG079627
InParanoidiQ9CWG9
KOiK16750
OMAiKYKDMRQ
OrthoDBiEOG091G0V5M
PhylomeDBiQ9CWG9
TreeFamiTF313861

Family and domain databases

InterProiView protein in InterPro
IPR019269 BLOC1_su2
PfamiView protein in Pfam
PF10046 BLOC1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CWG9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAAEGVPA TRREEQPPRD DAAVETAEEA KEPAEADINE LCRDMFSKMA
60 70 80 90 100
TYLTGELTAT SEDYKLLENM NKLTSLKYLE MKDIAINISR NLKDLNQKYA
110 120 130 140
ELQPYLDQIN MIEEQVAALE QAAYKLDAYS KKLEAKYKKL EKR
Length:143
Mass (Da):16,300
Last modified:June 1, 2001 - v1
Checksum:i4E1ED89D9F1E7A4C
GO

Sequence cautioni

The sequence AAH65806 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010745 mRNA Translation: BAB27155.1
AL928960 Genomic DNA No translation available.
BC065806 mRNA Translation: AAH65806.1 Different initiation.
CCDSiCCDS50445.1
RefSeqiNP_082883.1, NM_028607.1
UniGeneiMm.124685

Genome annotation databases

EnsembliENSMUST00000079033; ENSMUSP00000078042; ENSMUSG00000057506
GeneIDi73689
KEGGimmu:73689
UCSCiuc008hpl.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010745 mRNA Translation: BAB27155.1
AL928960 Genomic DNA No translation available.
BC065806 mRNA Translation: AAH65806.1 Different initiation.
CCDSiCCDS50445.1
RefSeqiNP_082883.1, NM_028607.1
UniGeneiMm.124685

3D structure databases

ProteinModelPortaliQ9CWG9
SMRiQ9CWG9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-1913 BLOC-1 complex
CORUMiQ9CWG9
STRINGi10090.ENSMUSP00000078042

PTM databases

iPTMnetiQ9CWG9
PhosphoSitePlusiQ9CWG9

Proteomic databases

EPDiQ9CWG9
MaxQBiQ9CWG9
PaxDbiQ9CWG9
PeptideAtlasiQ9CWG9
PRIDEiQ9CWG9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000079033; ENSMUSP00000078042; ENSMUSG00000057506
GeneIDi73689
KEGGimmu:73689
UCSCiuc008hpl.2 mouse

Organism-specific databases

CTDi282991
MGIiMGI:1920939 Bloc1s2

Phylogenomic databases

eggNOGiKOG4559 Eukaryota
ENOG4111XFP LUCA
GeneTreeiENSGT00390000005889
HOGENOMiHOG000111279
HOVERGENiHBG079627
InParanoidiQ9CWG9
KOiK16750
OMAiKYKDMRQ
OrthoDBiEOG091G0V5M
PhylomeDBiQ9CWG9
TreeFamiTF313861

Miscellaneous databases

PROiPR:Q9CWG9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000057506 Expressed in 19 organ(s), highest expression level in spleen
GenevisibleiQ9CWG9 MM

Family and domain databases

InterProiView protein in InterPro
IPR019269 BLOC1_su2
PfamiView protein in Pfam
PF10046 BLOC1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBL1S2_MOUSE
AccessioniPrimary (citable) accession number: Q9CWG9
Secondary accession number(s): A2ATZ7, Q6P062
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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