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Protein

Mitochondrial fission regulator 1-like

Gene

Mtfr1l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • aerobic respiration Source: GO_Central
  • mitochondrial fission Source: GO_Central

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial fission regulator 1-like
Gene namesi
Name:Mtfr1l
Synonyms:Fam54b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1924074 Mtfr1l

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003415671 – 289Mitochondrial fission regulator 1-likeAdd BLAST289

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei27PhosphothreonineBy similarity1
Modified residuei38PhosphoserineCombined sources1
Modified residuei100PhosphoserineCombined sources1
Modified residuei107PhosphoserineBy similarity1
Modified residuei221PhosphoserineCombined sources1
Modified residuei222PhosphoserineCombined sources1
Modified residuei235PhosphoserineBy similarity1
Modified residuei258PhosphoserineBy similarity1
Modified residuei270PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9CWE0
PaxDbiQ9CWE0
PeptideAtlasiQ9CWE0
PRIDEiQ9CWE0

PTM databases

iPTMnetiQ9CWE0
PhosphoSitePlusiQ9CWE0
SwissPalmiQ9CWE0

Expressioni

Gene expression databases

BgeeiENSMUSG00000046671 Expressed in 287 organ(s), highest expression level in heart
ExpressionAtlasiQ9CWE0 baseline and differential
GenevisibleiQ9CWE0 MM

Interactioni

Protein-protein interaction databases

BioGridi218339, 1 interactor
IntActiQ9CWE0, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ9CWE0
SMRiQ9CWE0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MTFR1 family.Curated

Phylogenomic databases

eggNOGiENOG410IEAK Eukaryota
ENOG4111FGJ LUCA
GeneTreeiENSGT00530000063223
HOGENOMiHOG000081765
HOVERGENiHBG103166
InParanoidiQ9CWE0
OMAiDTRPLKH
OrthoDBiEOG091G0DDL
PhylomeDBiQ9CWE0
TreeFamiTF331404

Family and domain databases

InterProiView protein in InterPro
IPR007972 Mtfr1
PANTHERiPTHR14215 PTHR14215, 1 hit
PfamiView protein in Pfam
PF05308 Mito_fiss_reg, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9CWE0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEANVTIPIW QNKPHGAARS VVRRIGTNLP LKPCPRASFE TLPNISDLCL
60 70 80 90 100
KDVPPVPTLA DIAWIAADEE ETYARVRSDT RPLRHTWKPS PLIVMQRNAS
110 120 130 140 150
VPNLRGSEER LLALKKPALP ALSRTTELQD ELSHLRSQIA KIVAADAASA
160 170 180 190 200
SLTPDFFSSG SSNVSSPLPC FGSSLHSTTS FVISDITEET EVEVPELPTV
210 220 230 240 250
PLLCSASPEC CKPEHKTTCS SSEEDDCISL SKASSFADMM GILKDFHRIK
260 270 280
QSQDLSRSLL KEEDPAVLIS EVLRRKFALK EEDISRKGN
Length:289
Mass (Da):31,726
Last modified:June 1, 2001 - v1
Checksum:i3CA0B5A8F33699B5
GO
Isoform 2 (identifier: Q9CWE0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     94-289: VMQRNASVPN...KEEDISRKGN → EIFFFHGLSPSRKEK

Note: No experimental confirmation available.
Show »
Length:108
Mass (Da):12,225
Checksum:i10A9DE8CB4AE3CAB
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YW54D3YW54_MOUSE
Mitochondrial fission regulator 1-l...
Mtfr1l Fam54b
237Annotation score:
D3Z0X8D3Z0X8_MOUSE
Mitochondrial fission regulator 1-l...
Mtfr1l Fam54b
225Annotation score:
D6RCX5D6RCX5_MOUSE
Mitochondrial fission regulator 1-l...
Mtfr1l Fam54b
202Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti33P → L in BAE27152 (PubMed:16141072).Curated1
Sequence conflicti158S → Y in BAE27152 (PubMed:16141072).Curated1
Sequence conflicti188E → K in BAE27152 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03434094 – 289VMQRN…SRKGN → EIFFFHGLSPSRKEK in isoform 2. 1 PublicationAdd BLAST196

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010825 mRNA Translation: BAB27207.1
AK089141 mRNA Translation: BAC40763.1
AK145362 mRNA Translation: BAE26389.1
AK146416 mRNA Translation: BAE27152.1
AK164004 mRNA Translation: BAE37584.1
AK169047 mRNA Translation: BAE40835.1
AK171703 mRNA Translation: BAE42619.1
BC026808 mRNA Translation: AAH26808.1
CCDSiCCDS18775.1 [Q9CWE0-1]
RefSeqiNP_001243041.1, NM_001256112.1 [Q9CWE0-1]
NP_084035.1, NM_029759.4 [Q9CWE0-1]
XP_006539319.1, XM_006539256.1 [Q9CWE0-1]
XP_006539320.1, XM_006539257.2
XP_006539321.1, XM_006539258.2 [Q9CWE0-1]
UniGeneiMm.30153

Genome annotation databases

EnsembliENSMUST00000102550; ENSMUSP00000099609; ENSMUSG00000046671 [Q9CWE0-1]
ENSMUST00000116279; ENSMUSP00000111983; ENSMUSG00000046671 [Q9CWE0-1]
GeneIDi76824
KEGGimmu:76824
UCSCiuc008vfi.2 mouse [Q9CWE0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010825 mRNA Translation: BAB27207.1
AK089141 mRNA Translation: BAC40763.1
AK145362 mRNA Translation: BAE26389.1
AK146416 mRNA Translation: BAE27152.1
AK164004 mRNA Translation: BAE37584.1
AK169047 mRNA Translation: BAE40835.1
AK171703 mRNA Translation: BAE42619.1
BC026808 mRNA Translation: AAH26808.1
CCDSiCCDS18775.1 [Q9CWE0-1]
RefSeqiNP_001243041.1, NM_001256112.1 [Q9CWE0-1]
NP_084035.1, NM_029759.4 [Q9CWE0-1]
XP_006539319.1, XM_006539256.1 [Q9CWE0-1]
XP_006539320.1, XM_006539257.2
XP_006539321.1, XM_006539258.2 [Q9CWE0-1]
UniGeneiMm.30153

3D structure databases

ProteinModelPortaliQ9CWE0
SMRiQ9CWE0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi218339, 1 interactor
IntActiQ9CWE0, 1 interactor

PTM databases

iPTMnetiQ9CWE0
PhosphoSitePlusiQ9CWE0
SwissPalmiQ9CWE0

Proteomic databases

EPDiQ9CWE0
PaxDbiQ9CWE0
PeptideAtlasiQ9CWE0
PRIDEiQ9CWE0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102550; ENSMUSP00000099609; ENSMUSG00000046671 [Q9CWE0-1]
ENSMUST00000116279; ENSMUSP00000111983; ENSMUSG00000046671 [Q9CWE0-1]
GeneIDi76824
KEGGimmu:76824
UCSCiuc008vfi.2 mouse [Q9CWE0-1]

Organism-specific databases

CTDi56181
MGIiMGI:1924074 Mtfr1l

Phylogenomic databases

eggNOGiENOG410IEAK Eukaryota
ENOG4111FGJ LUCA
GeneTreeiENSGT00530000063223
HOGENOMiHOG000081765
HOVERGENiHBG103166
InParanoidiQ9CWE0
OMAiDTRPLKH
OrthoDBiEOG091G0DDL
PhylomeDBiQ9CWE0
TreeFamiTF331404

Miscellaneous databases

PROiPR:Q9CWE0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000046671 Expressed in 287 organ(s), highest expression level in heart
ExpressionAtlasiQ9CWE0 baseline and differential
GenevisibleiQ9CWE0 MM

Family and domain databases

InterProiView protein in InterPro
IPR007972 Mtfr1
PANTHERiPTHR14215 PTHR14215, 1 hit
PfamiView protein in Pfam
PF05308 Mito_fiss_reg, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMFR1L_MOUSE
AccessioniPrimary (citable) accession number: Q9CWE0
Secondary accession number(s): Q3UJK3, Q8BTP7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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