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Protein

Nucleoside diphosphate-linked moiety X motif 17

Gene

Nudt17

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.By similarity

Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi142Magnesium or manganeseBy similarity1
Metal bindingi146Magnesium or manganeseBy similarity1

GO - Molecular functioni

  • hydrolase activity Source: GO_Central
  • metal ion binding Source: UniProtKB-KW
  • NADH pyrophosphatase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandMagnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoside diphosphate-linked moiety X motif 17 (EC:3.6.1.-)
Short name:
Nudix motif 17
Gene namesi
Name:Nudt17
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1925623 Nudt17

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000199541 – 296Nucleoside diphosphate-linked moiety X motif 17Add BLAST296

Proteomic databases

PRIDEiQ9CWD3

PTM databases

PhosphoSitePlusiQ9CWD3

Expressioni

Gene expression databases

BgeeiENSMUSG00000028100 Expressed in 107 organ(s), highest expression level in ear
ExpressionAtlasiQ9CWD3 baseline and differential
GenevisibleiQ9CWD3 MM

Structurei

3D structure databases

ProteinModelPortaliQ9CWD3
SMRiQ9CWD3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini90 – 236Nudix hydrolasePROSITE-ProRule annotationAdd BLAST147

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi127 – 148Nudix boxAdd BLAST22

Sequence similaritiesi

Belongs to the Nudix hydrolase family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000013847
HOVERGENiHBG056751
InParanoidiQ9CWD3
OMAiLPKYHHI
OrthoDBiEOG091G0G7N
PhylomeDBiQ9CWD3
TreeFamiTF313611

Family and domain databases

InterProiView protein in InterPro
IPR015797 NUDIX_hydrolase-like_dom_sf
IPR000086 NUDIX_hydrolase_dom
PfamiView protein in Pfam
PF00293 NUDIX, 1 hit
SUPFAMiSSF55811 SSF55811, 1 hit
PROSITEiView protein in PROSITE
PS51462 NUDIX, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9CWD3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAARLLLRL AGRLESVSFT QSVCGLLGAG QRPGPWHTHC SLERGQLVLS
60 70 80 90 100
SNPFPGASER LPIQRPLFCP FAALDQQPEV SKTEPLTNRG VDLGVAVILQ
110 120 130 140 150
SSDQTVLLTR RTCTLRISPN LWVPPGGHME PDEEILECGF RELWEECGLQ
160 170 180 190 200
LPKNQFSCVL LGLWESAYPP RLSWGFPKYH HLILYVLVIS QESQEQLQAR
210 220 230 240 250
IQVNPNEVNA FMWLGPDVAA AVVATEDGTR TPGLFSQDLP LSVCATELKD
260 270 280 290
DGGTQPLVLP MPTLMRTTPT TAEEDKERIG AGTKFALQLW LQHLGR
Length:296
Mass (Da):32,681
Last modified:June 1, 2001 - v1
Checksum:i09439EAD2F1CFBB3
GO
Isoform 2 (identifier: Q9CWD3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     125-134: PGGHMEPDEE → PDFLCPLENGVPGGRQQPFTLGPLLLQ

Show »
Length:313
Mass (Da):34,491
Checksum:i564864481B15080B
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JES0A0A0G2JES0_MOUSE
MCG14855, isoform CRA_a
Nudt17 mCG_14855
131Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_037799125 – 134PGGHMEPDEE → PDFLCPLENGVPGGRQQPFT LGPLLLQ in isoform 2. 1 Publication10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK019109 mRNA Translation: BAB31551.1
AK134929 mRNA Translation: BAE22341.1
AK141256 mRNA Translation: BAE24619.1
BC115559 mRNA Translation: AAI15560.1
CCDSiCCDS51008.1 [Q9CWD3-1]
CCDS51009.1 [Q9CWD3-2]
RefSeqiNP_001156397.1, NM_001162925.1 [Q9CWD3-2]
NP_084370.1, NM_030094.1 [Q9CWD3-1]
UniGeneiMm.423186

Genome annotation databases

EnsembliENSMUST00000029742; ENSMUSP00000029742; ENSMUSG00000028100 [Q9CWD3-2]
ENSMUST00000171249; ENSMUSP00000129851; ENSMUSG00000028100 [Q9CWD3-1]
GeneIDi78373
KEGGimmu:78373
UCSCiuc008qny.2 mouse [Q9CWD3-2]
uc008qnz.2 mouse [Q9CWD3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK019109 mRNA Translation: BAB31551.1
AK134929 mRNA Translation: BAE22341.1
AK141256 mRNA Translation: BAE24619.1
BC115559 mRNA Translation: AAI15560.1
CCDSiCCDS51008.1 [Q9CWD3-1]
CCDS51009.1 [Q9CWD3-2]
RefSeqiNP_001156397.1, NM_001162925.1 [Q9CWD3-2]
NP_084370.1, NM_030094.1 [Q9CWD3-1]
UniGeneiMm.423186

3D structure databases

ProteinModelPortaliQ9CWD3
SMRiQ9CWD3
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSitePlusiQ9CWD3

Proteomic databases

PRIDEiQ9CWD3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029742; ENSMUSP00000029742; ENSMUSG00000028100 [Q9CWD3-2]
ENSMUST00000171249; ENSMUSP00000129851; ENSMUSG00000028100 [Q9CWD3-1]
GeneIDi78373
KEGGimmu:78373
UCSCiuc008qny.2 mouse [Q9CWD3-2]
uc008qnz.2 mouse [Q9CWD3-1]

Organism-specific databases

CTDi200035
MGIiMGI:1925623 Nudt17

Phylogenomic databases

GeneTreeiENSGT00390000013847
HOVERGENiHBG056751
InParanoidiQ9CWD3
OMAiLPKYHHI
OrthoDBiEOG091G0G7N
PhylomeDBiQ9CWD3
TreeFamiTF313611

Miscellaneous databases

PROiPR:Q9CWD3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028100 Expressed in 107 organ(s), highest expression level in ear
ExpressionAtlasiQ9CWD3 baseline and differential
GenevisibleiQ9CWD3 MM

Family and domain databases

InterProiView protein in InterPro
IPR015797 NUDIX_hydrolase-like_dom_sf
IPR000086 NUDIX_hydrolase_dom
PfamiView protein in Pfam
PF00293 NUDIX, 1 hit
SUPFAMiSSF55811 SSF55811, 1 hit
PROSITEiView protein in PROSITE
PS51462 NUDIX, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNUD17_MOUSE
AccessioniPrimary (citable) accession number: Q9CWD3
Secondary accession number(s): Q14BX3, Q3URR9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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