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Protein

Mitochondrial amidoxime-reducing component 1

Gene

Marc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

As a component of an N-hydroxylated prodrug-converting complex required to reduce N-hydroxylated prodrugs, such as benzamidoxime. Also able to reduce N(omega)-hydroxy-L-arginine (NOHA) and N(omega)-hydroxy-N(delta)-methyl-L-arginine (NHAM) into L-arginine and N(delta)-methyl-L-arginine, respectively (By similarity).By similarity

Cofactori

Mo-molybdopterinBy similarityNote: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandMolybdenum

Enzyme and pathway databases

ReactomeiR-MMU-211945 Phase I - Functionalization of compounds

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial amidoxime-reducing component 1 (EC:1.-.-.-)
Short name:
mARC1
Alternative name(s):
Molybdenum cofactor sulfurase C-terminal domain-containing protein 1
Short name:
MOSC domain-containing protein 1
Short name:
Moco sulfurase C-terminal domain-containing protein 1
Gene namesi
Name:Marc1
Synonyms:Mosc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1913362 Marc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 24Mitochondrial matrixBy similarityAdd BLAST23
Transmembranei25 – 44Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST20
Topological domaini45 – 340CytoplasmicBy similarityAdd BLAST296

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002733362 – 340Mitochondrial amidoxime-reducing component 1Add BLAST339

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

MaxQBiQ9CW42
PaxDbiQ9CW42
PRIDEiQ9CW42

PTM databases

iPTMnetiQ9CW42
PhosphoSitePlusiQ9CW42
SwissPalmiQ9CW42

Expressioni

Gene expression databases

BgeeiENSMUSG00000026621 Expressed in 65 organ(s), highest expression level in liver
CleanExiMM_MOSC1
ExpressionAtlasiQ9CW42 baseline and differential
GenevisibleiQ9CW42 MM

Interactioni

Subunit structurei

Component of a complex composed of cytochrome b5, NADH-cytochrome b5 reductase and MARC1.By similarity

Protein-protein interaction databases

IntActiQ9CW42, 2 interactors
MINTiQ9CW42
STRINGi10090.ENSMUSP00000106620

Structurei

3D structure databases

ProteinModelPortaliQ9CW42
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini191 – 338MOSCPROSITE-ProRule annotationAdd BLAST148

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2362 Eukaryota
COG3217 LUCA
GeneTreeiENSGT00530000063150
HOGENOMiHOG000180196
HOVERGENiHBG081982
InParanoidiQ9CW42

Family and domain databases

InterProiView protein in InterPro
IPR005302 MoCF_Sase_C
IPR005303 MOSC_N
IPR011037 Pyrv_Knase-like_insert_dom_sf
PfamiView protein in Pfam
PF03473 MOSC, 1 hit
PF03476 MOSC_N, 1 hit
SUPFAMiSSF50800 SSF50800, 1 hit
PROSITEiView protein in PROSITE
PS51340 MOSC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9CW42-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGAGSWALTL FGFSAFRVPG QPRSTWLGVA ALGLAAVALG TVAWRRARPR
60 70 80 90 100
RRRRLQQVGT VAQLWIYPIK SCKGLSVSEA ECTAMGLRYG HLRDRFWLVI
110 120 130 140 150
NEEGNMVTAR QEPRLVLISL TCEDDTLTLS AAYTKDLLLP ITPPATNPLL
160 170 180 190 200
QCRVHGLEIQ GRDCGEDAAQ WVSSFLKMQS CRLVHFEPHM RPRSSRQMKA
210 220 230 240 250
VFRTKDQVAY SDASPFLVLS EASLEDLNSR LERRVKATNF RPNIVISGCG
260 270 280 290 300
VYAEDSWNEV LIGDVELKRV MACTRCLLTT VDPDTGISDR KEPLETLKSY
310 320 330 340
RLCDPSEQAL YGKLPIFGQY FALENPGTIR VGDPVYLLGQ
Length:340
Mass (Da):37,979
Last modified:January 23, 2007 - v2
Checksum:i2EB4A29C10E7DC50
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YZZ3D3YZZ3_MOUSE
Mitochondrial amidoxime-reducing co...
Marc1 Mosc1
342Annotation score:
A0A087WPC2A0A087WPC2_MOUSE
Mitochondrial amidoxime-reducing co...
Marc1
235Annotation score:

Sequence cautioni

The sequence AAH28441 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB23724 differs from that shown. Reason: Frameshift at position 53.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti251V → I in AAH28441 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004989 mRNA Translation: BAB23724.1 Frameshift.
BC028441 mRNA Translation: AAH28441.1 Different initiation.
CCDSiCCDS69987.1
RefSeqiNP_001277202.1, NM_001290273.1
UniGeneiMm.272457

Genome annotation databases

EnsembliENSMUST00000048462; ENSMUSP00000035804; ENSMUSG00000026621
GeneIDi66112
KEGGimmu:66112
UCSCiuc007dyp.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004989 mRNA Translation: BAB23724.1 Frameshift.
BC028441 mRNA Translation: AAH28441.1 Different initiation.
CCDSiCCDS69987.1
RefSeqiNP_001277202.1, NM_001290273.1
UniGeneiMm.272457

3D structure databases

ProteinModelPortaliQ9CW42
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9CW42, 2 interactors
MINTiQ9CW42
STRINGi10090.ENSMUSP00000106620

PTM databases

iPTMnetiQ9CW42
PhosphoSitePlusiQ9CW42
SwissPalmiQ9CW42

Proteomic databases

MaxQBiQ9CW42
PaxDbiQ9CW42
PRIDEiQ9CW42

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048462; ENSMUSP00000035804; ENSMUSG00000026621
GeneIDi66112
KEGGimmu:66112
UCSCiuc007dyp.2 mouse

Organism-specific databases

CTDi64757
MGIiMGI:1913362 Marc1

Phylogenomic databases

eggNOGiKOG2362 Eukaryota
COG3217 LUCA
GeneTreeiENSGT00530000063150
HOGENOMiHOG000180196
HOVERGENiHBG081982
InParanoidiQ9CW42

Enzyme and pathway databases

ReactomeiR-MMU-211945 Phase I - Functionalization of compounds

Miscellaneous databases

PROiPR:Q9CW42
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026621 Expressed in 65 organ(s), highest expression level in liver
CleanExiMM_MOSC1
ExpressionAtlasiQ9CW42 baseline and differential
GenevisibleiQ9CW42 MM

Family and domain databases

InterProiView protein in InterPro
IPR005302 MoCF_Sase_C
IPR005303 MOSC_N
IPR011037 Pyrv_Knase-like_insert_dom_sf
PfamiView protein in Pfam
PF03473 MOSC, 1 hit
PF03476 MOSC_N, 1 hit
SUPFAMiSSF50800 SSF50800, 1 hit
PROSITEiView protein in PROSITE
PS51340 MOSC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMARC1_MOUSE
AccessioniPrimary (citable) accession number: Q9CW42
Secondary accession number(s): Q8R2L6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 100 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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