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Protein

Actin-related protein 2/3 complex subunit 2

Gene

Arpc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the mother actin filament. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

ReactomeiR-MMU-2029482 Regulation of actin dynamics for phagocytic cup formation
R-MMU-3928662 EPHB-mediated forward signaling
R-MMU-5663213 RHO GTPases Activate WASPs and WAVEs
R-MMU-8856828 Clathrin-mediated endocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2/3 complex subunit 2
Alternative name(s):
Arp2/3 complex 34 kDa subunit
Short name:
p34-ARC
Gene namesi
Name:Arpc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1923959 Arpc2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Cytoskeleton, Nucleus, Synapse, Synaptosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001240341 – 300Actin-related protein 2/3 complex subunit 2Add BLAST300

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei275N6-acetyllysineBy similarity1
Modified residuei295N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9CVB6
MaxQBiQ9CVB6
PaxDbiQ9CVB6
PeptideAtlasiQ9CVB6
PRIDEiQ9CVB6

PTM databases

iPTMnetiQ9CVB6
PhosphoSitePlusiQ9CVB6
SwissPalmiQ9CVB6

Expressioni

Tissue specificityi

Expressed in hippocampal neurons (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000006304 Expressed in 292 organ(s), highest expression level in ear
CleanExiMM_ARPC2
ExpressionAtlasiQ9CVB6 baseline and differential
GenevisibleiQ9CVB6 MM

Interactioni

Subunit structurei

Component of the Arp2/3 complex composed of ACTR2/ARP2, ACTR3/ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC (By similarity). Interacts with SHANK3; the interaction probably mediates the association of SHANK3 with the Arp2/3 complex (PubMed:24153177).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi218272, 3 interactors
IntActiQ9CVB6, 8 interactors
MINTiQ9CVB6
STRINGi10090.ENSMUSP00000006467

Structurei

3D structure databases

ProteinModelPortaliQ9CVB6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ARPC2 family.Curated

Phylogenomic databases

eggNOGiKOG2826 Eukaryota
ENOG410YKF6 LUCA
GeneTreeiENSGT00390000016794
HOVERGENiHBG050580
InParanoidiQ9CVB6
KOiK05758
OMAiEETMYVE
OrthoDBiEOG091G0BUH
TreeFamiTF315006

Family and domain databases

Gene3Di3.30.1460.20, 2 hits
InterProiView protein in InterPro
IPR007188 ARPC2
IPR034666 ARPC2/4
PANTHERiPTHR12058 PTHR12058, 1 hit
PfamiView protein in Pfam
PF04045 P34-Arc, 1 hit
SUPFAMiSSF69645 SSF69645, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9CVB6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MILLEVNNRI IEETLALKFE NAAAGNKPEA VEVTFADFDG VLYHISNPNG
60 70 80 90 100
DKTKVMVSIS LKFYKELQAH GADELLKRVY GSFLVNPEPG YNVSLLYDLE
110 120 130 140 150
NLPASKDSIV HQAGMLKRNC FASVFEKYFQ FQEEGKEGEN RAVIHYRDDE
160 170 180 190 200
TMYVESKKDR VTVVFSTVFK DDDDVVIGKV FMQEFKEGRR ASHTAPQVLF
210 220 230 240 250
SHREPPLELK DTDAAVGDNI GYITFVLFPR HTNATARDNT INLIHTFRDY
260 270 280 290 300
LHYHIKCSKA YIHTRMRAKT SDFLKVLNRA RPDAEKKEMK TITGKTFSSR
Length:300
Mass (Da):34,357
Last modified:July 25, 2006 - v3
Checksum:i6A5D8500D641DB60
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YXG6D3YXG6_MOUSE
Arp2/3 complex 34 kDa subunit
Arpc2 mCG_114810
284Annotation score:
A0A087WRT2A0A087WRT2_MOUSE
Actin-related protein 2/3 complex s...
Arpc2
26Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008777 mRNA Translation: BAB25889.2
AK152356 mRNA Translation: BAE31148.1
BC115750 mRNA Translation: AAI15751.1
CCDSiCCDS35612.1
RefSeqiNP_083987.1, NM_029711.1
XP_006496380.1, XM_006496317.2
UniGeneiMm.337038

Genome annotation databases

EnsembliENSMUST00000006467; ENSMUSP00000006467; ENSMUSG00000006304
ENSMUST00000113820; ENSMUSP00000109451; ENSMUSG00000006304
GeneIDi76709
KEGGimmu:76709
UCSCiuc007bln.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008777 mRNA Translation: BAB25889.2
AK152356 mRNA Translation: BAE31148.1
BC115750 mRNA Translation: AAI15751.1
CCDSiCCDS35612.1
RefSeqiNP_083987.1, NM_029711.1
XP_006496380.1, XM_006496317.2
UniGeneiMm.337038

3D structure databases

ProteinModelPortaliQ9CVB6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi218272, 3 interactors
IntActiQ9CVB6, 8 interactors
MINTiQ9CVB6
STRINGi10090.ENSMUSP00000006467

PTM databases

iPTMnetiQ9CVB6
PhosphoSitePlusiQ9CVB6
SwissPalmiQ9CVB6

Proteomic databases

EPDiQ9CVB6
MaxQBiQ9CVB6
PaxDbiQ9CVB6
PeptideAtlasiQ9CVB6
PRIDEiQ9CVB6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000006467; ENSMUSP00000006467; ENSMUSG00000006304
ENSMUST00000113820; ENSMUSP00000109451; ENSMUSG00000006304
GeneIDi76709
KEGGimmu:76709
UCSCiuc007bln.1 mouse

Organism-specific databases

CTDi10109
MGIiMGI:1923959 Arpc2

Phylogenomic databases

eggNOGiKOG2826 Eukaryota
ENOG410YKF6 LUCA
GeneTreeiENSGT00390000016794
HOVERGENiHBG050580
InParanoidiQ9CVB6
KOiK05758
OMAiEETMYVE
OrthoDBiEOG091G0BUH
TreeFamiTF315006

Enzyme and pathway databases

ReactomeiR-MMU-2029482 Regulation of actin dynamics for phagocytic cup formation
R-MMU-3928662 EPHB-mediated forward signaling
R-MMU-5663213 RHO GTPases Activate WASPs and WAVEs
R-MMU-8856828 Clathrin-mediated endocytosis

Miscellaneous databases

ChiTaRSiArpc2 mouse
PROiPR:Q9CVB6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000006304 Expressed in 292 organ(s), highest expression level in ear
CleanExiMM_ARPC2
ExpressionAtlasiQ9CVB6 baseline and differential
GenevisibleiQ9CVB6 MM

Family and domain databases

Gene3Di3.30.1460.20, 2 hits
InterProiView protein in InterPro
IPR007188 ARPC2
IPR034666 ARPC2/4
PANTHERiPTHR12058 PTHR12058, 1 hit
PfamiView protein in Pfam
PF04045 P34-Arc, 1 hit
SUPFAMiSSF69645 SSF69645, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiARPC2_MOUSE
AccessioniPrimary (citable) accession number: Q9CVB6
Secondary accession number(s): Q3U870
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: July 25, 2006
Last modified: November 7, 2018
This is version 128 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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