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Protein

52 kDa repressor of the inhibitor of the protein kinase

Gene

Thap12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR-inhibitory function of DNAJC3, resulting in restoration of kinase activity and suppression of cell growth.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1 – 86THAP-typePROSITE-ProRule annotationAdd BLAST86

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
52 kDa repressor of the inhibitor of the protein kinase
Short name:
p52rIPK
Alternative name(s):
58 kDa interferon-induced protein kinase-interacting protein
Short name:
p58IPK-interacting protein
THAP domain-containing protein 0
THAP domain-containing protein 12By similarity
Gene namesi
Name:Thap12By similarity
Synonyms:PrkrirImported, Thap0
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1920231 Thap12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000686351 – 75852 kDa repressor of the inhibitor of the protein kinaseAdd BLAST758

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei563PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9CUX1
MaxQBiQ9CUX1
PaxDbiQ9CUX1
PeptideAtlasiQ9CUX1
PRIDEiQ9CUX1

PTM databases

iPTMnetiQ9CUX1
PhosphoSitePlusiQ9CUX1

Expressioni

Gene expression databases

BgeeiENSMUSG00000030753 Expressed in 295 organ(s), highest expression level in skeletal muscle tissue
ExpressionAtlasiQ9CUX1 baseline and differential
GenevisibleiQ9CUX1 MM

Interactioni

Subunit structurei

Interacts with DNAJC3, probably sequestring it.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033009

Structurei

3D structure databases

ProteinModelPortaliQ9CUX1
SMRiQ9CUX1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1 – 86THAP-typePROSITE-ProRule annotationAdd BLAST86

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IHFF Eukaryota
ENOG4110ZMY LUCA
GeneTreeiENSGT00530000063516
HOGENOMiHOG000013127
HOVERGENiHBG007908
InParanoidiQ9CUX1
OMAiCKTSPYR
OrthoDBiEOG091G04DA
PhylomeDBiQ9CUX1
TreeFamiTF330114

Family and domain databases

Gene3Di3.30.40.180, 1 hit
InterProiView protein in InterPro
IPR025398 DUF4371
IPR008906 HATC_C_dom
IPR012337 RNaseH-like_sf
IPR026625 TFII-I-rel
IPR006612 THAP_Znf
IPR038441 THAP_Znf_sf
PANTHERiPTHR11697 PTHR11697, 1 hit
PfamiView protein in Pfam
PF05699 Dimer_Tnp_hAT, 1 hit
PF14291 DUF4371, 1 hit
PF05485 THAP, 1 hit
SMARTiView protein in SMART
SM00692 DM3, 1 hit
SM00980 THAP, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit
PROSITEiView protein in PROSITE
PS50950 ZF_THAP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9CUX1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPNFCAAPNC TRKSTQSDLA FFRFPRDPAR CQKWVENCRR ADLEDKTPDQ
60 70 80 90 100
LNKHYRLCAK HFETSMICRT SPYRTVLRDN AIPTIFDLTS HLNNPHSRHR
110 120 130 140 150
KRIKELSEDE IRTLKQKKIE ETSEQEQETN TNAQNPSAEA VNQQDANVLP
160 170 180 190 200
LTLEEKENKE YLKSLFEILV LMGKQNIPLD GHEADEVPEG LFAPDNFQAL
210 220 230 240 250
LECRINSGEE VLRKRFEATA VNTLFCSKTQ QRHMLEICES CIREETLREV
260 270 280 290 300
RDSHFFSIIT DDVVDIAGEE HLPVLVRFVD DAHNLREEFV GFLPYEADAE
310 320 330 340 350
ILAVKFHTTI TEKWGLNMEY CRGQAYIVSS GFSSKMKVVA SRLLEKYPQA
360 370 380 390 400
VYTLCSSCAL NAWLAKSVPV IGVSVALGTI EEVCSFFHRS PQLLLELDSV
410 420 430 440 450
ISVLFQNSEE RAKELKEICH SQWTGRHDAF EILVDLLQAL VLCLDGIINS
460 470 480 490 500
DTNVRWNNYI AGRAFVLCSA VTDFDFIVTI VVLKNVLSFT RAFGKNLQGQ
510 520 530 540 550
TSDVFFAASS LTAVLHSLNE VMENIEVYHE FWFEEATNLA TKLDIQMKLP
560 570 580 590 600
GKFRRAQQGN LESQLTSESY YKDTLSVPTV EHIIQELKDI FSEQHLKALK
610 620 630 640 650
CLSLVPSVMG QLKFNTSEEH HADMYRSDLP NPDTLSAELH CWRIKWKHRG
660 670 680 690 700
KDIELPSTIY EALHLPDIKF FPNVYALLKV LCILPVMKVE NERYENGRKR
710 720 730 740 750
LKAYLRNTLT DQRSSNLALL NINFDIKHDL DLMVDTYIKL YTNKSELPTI

NSETIENT
Length:758
Mass (Da):87,021
Last modified:January 16, 2004 - v2
Checksum:i0BEDA3FAF680CE1F
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RH75D6RH75_MOUSE
52 kDa repressor of the inhibitor o...
Thap12 Prkrir, mCG_122622
120Annotation score:
D6RI43D6RI43_MOUSE
52 kDa repressor of the inhibitor o...
Thap12 Prkrir, mCG_122622
79Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC049103 mRNA Translation: AAH49103.1
AK013663 mRNA Translation: BAB28945.1
CCDSiCCDS21474.1
RefSeqiNP_082686.1, NM_028410.1
XP_011240217.1, XM_011241915.2
UniGeneiMm.4428

Genome annotation databases

EnsembliENSMUST00000033009; ENSMUSP00000033009; ENSMUSG00000030753
GeneIDi72981
KEGGimmu:72981
UCSCiuc009ikt.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC049103 mRNA Translation: AAH49103.1
AK013663 mRNA Translation: BAB28945.1
CCDSiCCDS21474.1
RefSeqiNP_082686.1, NM_028410.1
XP_011240217.1, XM_011241915.2
UniGeneiMm.4428

3D structure databases

ProteinModelPortaliQ9CUX1
SMRiQ9CUX1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033009

PTM databases

iPTMnetiQ9CUX1
PhosphoSitePlusiQ9CUX1

Proteomic databases

EPDiQ9CUX1
MaxQBiQ9CUX1
PaxDbiQ9CUX1
PeptideAtlasiQ9CUX1
PRIDEiQ9CUX1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033009; ENSMUSP00000033009; ENSMUSG00000030753
GeneIDi72981
KEGGimmu:72981
UCSCiuc009ikt.1 mouse

Organism-specific databases

CTDi5612
MGIiMGI:1920231 Thap12

Phylogenomic databases

eggNOGiENOG410IHFF Eukaryota
ENOG4110ZMY LUCA
GeneTreeiENSGT00530000063516
HOGENOMiHOG000013127
HOVERGENiHBG007908
InParanoidiQ9CUX1
OMAiCKTSPYR
OrthoDBiEOG091G04DA
PhylomeDBiQ9CUX1
TreeFamiTF330114

Miscellaneous databases

ChiTaRSiPrkrir mouse
PROiPR:Q9CUX1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030753 Expressed in 295 organ(s), highest expression level in skeletal muscle tissue
ExpressionAtlasiQ9CUX1 baseline and differential
GenevisibleiQ9CUX1 MM

Family and domain databases

Gene3Di3.30.40.180, 1 hit
InterProiView protein in InterPro
IPR025398 DUF4371
IPR008906 HATC_C_dom
IPR012337 RNaseH-like_sf
IPR026625 TFII-I-rel
IPR006612 THAP_Znf
IPR038441 THAP_Znf_sf
PANTHERiPTHR11697 PTHR11697, 1 hit
PfamiView protein in Pfam
PF05699 Dimer_Tnp_hAT, 1 hit
PF14291 DUF4371, 1 hit
PF05485 THAP, 1 hit
SMARTiView protein in SMART
SM00692 DM3, 1 hit
SM00980 THAP, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit
PROSITEiView protein in PROSITE
PS50950 ZF_THAP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiP52K_MOUSE
AccessioniPrimary (citable) accession number: Q9CUX1
Secondary accession number(s): Q80Y58
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: January 16, 2004
Last modified: November 7, 2018
This is version 109 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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