UniProtKB - Q9CUX1 (P52K_MOUSE)
Protein
52 kDa repressor of the inhibitor of the protein kinase
Gene
Thap12
Organism
Mus musculus (Mouse)
Status
Functioni
Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR-inhibitory function of DNAJC3, resulting in restoration of kinase activity and suppression of cell growth.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 1 – 86 | THAP-typePROSITE-ProRule annotationAdd BLAST | 86 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- protein dimerization activity Source: InterPro
Keywordsi
Molecular function | DNA-binding |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: 52 kDa repressor of the inhibitor of the protein kinaseShort name: p52rIPK Alternative name(s): 58 kDa interferon-induced protein kinase-interacting protein Short name: p58IPK-interacting protein THAP domain-containing protein 0 THAP domain-containing protein 12By similarity |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1920231, Thap12 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000068635 | 1 – 758 | 52 kDa repressor of the inhibitor of the protein kinaseAdd BLAST | 758 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 563 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9CUX1 |
MaxQBi | Q9CUX1 |
PaxDbi | Q9CUX1 |
PeptideAtlasi | Q9CUX1 |
PRIDEi | Q9CUX1 |
ProteomicsDBi | 287754 |
PTM databases
iPTMneti | Q9CUX1 |
PhosphoSitePlusi | Q9CUX1 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000030753, Expressed in gastrocnemius and 310 other tissues |
Genevisiblei | Q9CUX1, MM |
Interactioni
Subunit structurei
Interacts with DNAJC3, probably sequestring it.
By similarityGO - Molecular functioni
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
BioGRIDi | 215689, 3 interactors |
STRINGi | 10090.ENSMUSP00000033009 |
Miscellaneous databases
RNActi | Q9CUX1, protein |
Family & Domainsi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 1 – 86 | THAP-typePROSITE-ProRule annotationAdd BLAST | 86 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | ENOG502QU3U, Eukaryota |
GeneTreei | ENSGT00530000063516 |
HOGENOMi | CLU_023409_0_0_1 |
InParanoidi | Q9CUX1 |
OMAi | FFPNVNA |
OrthoDBi | 537563at2759 |
PhylomeDBi | Q9CUX1 |
TreeFami | TF330114 |
Family and domain databases
Gene3Di | 3.30.40.180, 1 hit |
InterProi | View protein in InterPro IPR025398, DUF4371 IPR008906, HATC_C_dom IPR012337, RNaseH-like_sf IPR006612, THAP_Znf IPR038441, THAP_Znf_sf |
Pfami | View protein in Pfam PF05699, Dimer_Tnp_hAT, 1 hit PF14291, DUF4371, 1 hit PF05485, THAP, 1 hit |
SMARTi | View protein in SMART SM00692, DM3, 1 hit SM00980, THAP, 1 hit |
SUPFAMi | SSF53098, SSF53098, 1 hit |
PROSITEi | View protein in PROSITE PS50950, ZF_THAP, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q9CUX1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPNFCAAPNC TRKSTQSDLA FFRFPRDPAR CQKWVENCRR ADLEDKTPDQ
60 70 80 90 100
LNKHYRLCAK HFETSMICRT SPYRTVLRDN AIPTIFDLTS HLNNPHSRHR
110 120 130 140 150
KRIKELSEDE IRTLKQKKIE ETSEQEQETN TNAQNPSAEA VNQQDANVLP
160 170 180 190 200
LTLEEKENKE YLKSLFEILV LMGKQNIPLD GHEADEVPEG LFAPDNFQAL
210 220 230 240 250
LECRINSGEE VLRKRFEATA VNTLFCSKTQ QRHMLEICES CIREETLREV
260 270 280 290 300
RDSHFFSIIT DDVVDIAGEE HLPVLVRFVD DAHNLREEFV GFLPYEADAE
310 320 330 340 350
ILAVKFHTTI TEKWGLNMEY CRGQAYIVSS GFSSKMKVVA SRLLEKYPQA
360 370 380 390 400
VYTLCSSCAL NAWLAKSVPV IGVSVALGTI EEVCSFFHRS PQLLLELDSV
410 420 430 440 450
ISVLFQNSEE RAKELKEICH SQWTGRHDAF EILVDLLQAL VLCLDGIINS
460 470 480 490 500
DTNVRWNNYI AGRAFVLCSA VTDFDFIVTI VVLKNVLSFT RAFGKNLQGQ
510 520 530 540 550
TSDVFFAASS LTAVLHSLNE VMENIEVYHE FWFEEATNLA TKLDIQMKLP
560 570 580 590 600
GKFRRAQQGN LESQLTSESY YKDTLSVPTV EHIIQELKDI FSEQHLKALK
610 620 630 640 650
CLSLVPSVMG QLKFNTSEEH HADMYRSDLP NPDTLSAELH CWRIKWKHRG
660 670 680 690 700
KDIELPSTIY EALHLPDIKF FPNVYALLKV LCILPVMKVE NERYENGRKR
710 720 730 740 750
LKAYLRNTLT DQRSSNLALL NINFDIKHDL DLMVDTYIKL YTNKSELPTI
NSETIENT
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD6RI43 | D6RI43_MOUSE | 52 kDa repressor of the inhibitor o... | Thap12 Prkrir | 79 | Annotation score: | ||
D6RH75 | D6RH75_MOUSE | 52 kDa repressor of the inhibitor o... | Thap12 Prkrir | 120 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC049103 mRNA Translation: AAH49103.1 AK013663 mRNA Translation: BAB28945.1 |
CCDSi | CCDS21474.1 |
RefSeqi | NP_082686.1, NM_028410.1 XP_011240217.1, XM_011241915.2 |
Genome annotation databases
Ensembli | ENSMUST00000033009; ENSMUSP00000033009; ENSMUSG00000030753 |
GeneIDi | 72981 |
KEGGi | mmu:72981 |
UCSCi | uc009ikt.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC049103 mRNA Translation: AAH49103.1 AK013663 mRNA Translation: BAB28945.1 |
CCDSi | CCDS21474.1 |
RefSeqi | NP_082686.1, NM_028410.1 XP_011240217.1, XM_011241915.2 |
3D structure databases
SMRi | Q9CUX1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 215689, 3 interactors |
STRINGi | 10090.ENSMUSP00000033009 |
PTM databases
iPTMneti | Q9CUX1 |
PhosphoSitePlusi | Q9CUX1 |
Proteomic databases
EPDi | Q9CUX1 |
MaxQBi | Q9CUX1 |
PaxDbi | Q9CUX1 |
PeptideAtlasi | Q9CUX1 |
PRIDEi | Q9CUX1 |
ProteomicsDBi | 287754 |
Protocols and materials databases
Antibodypediai | 2160, 158 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000033009; ENSMUSP00000033009; ENSMUSG00000030753 |
GeneIDi | 72981 |
KEGGi | mmu:72981 |
UCSCi | uc009ikt.1, mouse |
Organism-specific databases
CTDi | 5612 |
MGIi | MGI:1920231, Thap12 |
Phylogenomic databases
eggNOGi | ENOG502QU3U, Eukaryota |
GeneTreei | ENSGT00530000063516 |
HOGENOMi | CLU_023409_0_0_1 |
InParanoidi | Q9CUX1 |
OMAi | FFPNVNA |
OrthoDBi | 537563at2759 |
PhylomeDBi | Q9CUX1 |
TreeFami | TF330114 |
Miscellaneous databases
BioGRID-ORCSi | 72981, 26 hits in 53 CRISPR screens |
ChiTaRSi | Prkrir, mouse |
PROi | PR:Q9CUX1 |
RNActi | Q9CUX1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000030753, Expressed in gastrocnemius and 310 other tissues |
Genevisiblei | Q9CUX1, MM |
Family and domain databases
Gene3Di | 3.30.40.180, 1 hit |
InterProi | View protein in InterPro IPR025398, DUF4371 IPR008906, HATC_C_dom IPR012337, RNaseH-like_sf IPR006612, THAP_Znf IPR038441, THAP_Znf_sf |
Pfami | View protein in Pfam PF05699, Dimer_Tnp_hAT, 1 hit PF14291, DUF4371, 1 hit PF05485, THAP, 1 hit |
SMARTi | View protein in SMART SM00692, DM3, 1 hit SM00980, THAP, 1 hit |
SUPFAMi | SSF53098, SSF53098, 1 hit |
PROSITEi | View protein in PROSITE PS50950, ZF_THAP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | P52K_MOUSE | |
Accessioni | Q9CUX1Primary (citable) accession number: Q9CUX1 Secondary accession number(s): Q80Y58 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 11, 2003 |
Last sequence update: | January 16, 2004 | |
Last modified: | April 7, 2021 | |
This is version 119 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot