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Protein

Zinc finger MYM-type protein 2

Gene

Zmym2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function as a transcription factor.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri351 – 385MYM-type 1Add BLAST35
Zinc fingeri397 – 437MYM-type 2Add BLAST41
Zinc fingeri444 – 479MYM-type 3Add BLAST36
Zinc fingeri490 – 518MYM-type 4Add BLAST29
Zinc fingeri558 – 596MYM-type 5Add BLAST39
Zinc fingeri604 – 651MYM-type 6Add BLAST48
Zinc fingeri659 – 693MYM-type 7Add BLAST35
Zinc fingeri700 – 739MYM-type 8Add BLAST40
Zinc fingeri746 – 780MYM-type 9Add BLAST35

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger MYM-type protein 2
Alternative name(s):
Zinc finger protein 198
Gene namesi
Name:Zmym2
Synonyms:Zfp198, Znf198
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1923257 Zmym2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001913831 – 1376Zinc finger MYM-type protein 2Add BLAST1376

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki48Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki88Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki98Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki104Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki147Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki253Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki297Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei305PhosphoserineBy similarity1
Cross-linki312Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki324Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki347Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki365Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki416Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki440Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki490Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki502Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki512Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki528Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki531Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki575Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki602Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki648Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki657Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki687Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki699Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki708Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki763Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki787Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki811Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki828Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei837PhosphoserineBy similarity1
Modified residuei1063PhosphoserineCombined sources1
Modified residuei1375PhosphothreonineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9CU65
MaxQBiQ9CU65
PaxDbiQ9CU65
PeptideAtlasiQ9CU65
PRIDEiQ9CU65

PTM databases

iPTMnetiQ9CU65
PhosphoSitePlusiQ9CU65

Expressioni

Gene expression databases

BgeeiENSMUSG00000021945 Expressed in 243 organ(s), highest expression level in pes
CleanExiMM_ZMYM2
ExpressionAtlasiQ9CU65 baseline and differential
GenevisibleiQ9CU65 MM

Interactioni

Subunit structurei

May be a component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST, PHF21A/BHC80, ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi217903, 12 interactors
DIPiDIP-29928N
IntActiQ9CU65, 3 interactors
MINTiQ9CU65
STRINGi10090.ENSMUSP00000022511

Structurei

3D structure databases

ProteinModelPortaliQ9CU65
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri351 – 385MYM-type 1Add BLAST35
Zinc fingeri397 – 437MYM-type 2Add BLAST41
Zinc fingeri444 – 479MYM-type 3Add BLAST36
Zinc fingeri490 – 518MYM-type 4Add BLAST29
Zinc fingeri558 – 596MYM-type 5Add BLAST39
Zinc fingeri604 – 651MYM-type 6Add BLAST48
Zinc fingeri659 – 693MYM-type 7Add BLAST35
Zinc fingeri700 – 739MYM-type 8Add BLAST40
Zinc fingeri746 – 780MYM-type 9Add BLAST35

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IE8I Eukaryota
ENOG410XQR6 LUCA
GeneTreeiENSGT00550000074408
HOGENOMiHOG000293258
HOVERGENiHBG057545
InParanoidiQ9CU65
OMAiAYGVNAW
OrthoDBiEOG091G00KQ
PhylomeDBiQ9CU65
TreeFamiTF336988

Family and domain databases

InterProiView protein in InterPro
IPR021893 DUF3504
IPR026625 TFII-I-rel
IPR011017 TRASH_dom
IPR010507 Znf_MYM
PANTHERiPTHR11697 PTHR11697, 1 hit
PfamiView protein in Pfam
PF12012 DUF3504, 1 hit
PF06467 zf-FCS, 8 hits
SMARTiView protein in SMART
SM00746 TRASH, 9 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9CU65-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDTSSVGTLE LTDQTPVLLG STAMATSLTN VGNSFSGPPN PLVSRSSKFQ
60 70 80 90 100
NSSVEDDDDV VFIEPVQPPP SSAPLVADQR PITFTSSKNE ELQGNDPKIL
110 120 130 140 150
PSSKELAPQK GSVSETIVID DEEDMETNQG QEKSSSNFIE RRPSETKNRT
160 170 180 190 200
NDVDFSSSTF SRSKVNAGVS NSGITTEPDS EIQIANVTTL ETGVSSVSDG
210 220 230 240 250
QLESTDGRDM NLMITHVTSL HNTSLGDGSN GLQSSNFGVN IQTYTPSLTS
260 270 280 290 300
QTKAGVGPFN PGRMNVAGDV FQNGESAPHH NPDSWISQSA SFPRNQKQQG
310 320 330 340 350
VDSLSPVASL PKQIFQPSNQ QPTKPVKVTC ANCKKPLQKG QTAYQRKGSA
360 370 380 390 400
HLFCSTTCLS SFSHKPAPKK LCVMCKKDIT TMKGTIVAQV DSSESFQEFC
410 420 430 440 450
STSCLSLYED KQSPAKGALN KSRCTICGKL TEIRHEVSFK NMTHKLCSDH
460 470 480 490 500
CFNRYRMANG LIMNCCEQCG EYLPSKGAGN NVLVVDGQQK RFCCQSCVTE
510 520 530 540 550
YKQVGSHPSF LKEVRDHMQD SFLMQPEKYG KLTTCTGCRT QCRFFDMTQC
560 570 580 590 600
IGPNGYMEPY CSTACMNSHK TKYAKSQSLG IICHFCKRNS LPQYQATMPD
610 620 630 640 650
GKLYNFCNSS CVAKFQALSM QSSPNGQFVA PSDIQLKCNY CKNSFCSKPE
660 670 680 690 700
ILEWENKVHQ FCSKTCSDDY KKLHCIVTYC EYCQEEKTLH ETVNFSGVKR
710 720 730 740 750
PFCSEGCKLL YKQDFARRLG LRCVTCNYCS QLCKKGATKE LDGVVRDFCS
760 770 780 790 800
EDCCKKFQEW YYKAARCDCC KSQGTLKERV QWRGEMKHFC DQHCLLRFYC
810 820 830 840 850
QQNEPNMTTQ KGPENLHYDQ GCQTSRTKMT GSAPPPSPTP NKEMKNKAIL
860 870 880 890 900
CKPLTMTKAT YCKPHMQTKS CQTDENWKTE YVPVPIPVPV YVPVPMHMYS
910 920 930 940 950
QNIPVPTTVP VPVPVPVFLP APLDSSEKIP ATVEDLKSKV SSDPLDSELL
960 970 980 990 1000
TMTDMMTEEE GKAEASNINS VIIETDIIGS DLTKNSDPDI QSNMPDVPYE
1010 1020 1030 1040 1050
PDLDIEIDFP RAAEELDMEN EFLLPPVFGE EYEEQPRPRS KKKGTKRKAV
1060 1070 1080 1090 1100
SGYQSHDDSS DNSECSFPFK YTYGVNAWKH WVKTRQLDED LLVLDELKSS
1110 1120 1130 1140 1150
KSVKLKEDLL SHTTAELNYG LAHFVNEIRR PNGENYAPDS IYYLCLGIQE
1160 1170 1180 1190 1200
YLCGSNRKDN IFIDPGYQMF EQELNKILRS WQPSILPDGS IFSRVEEDYL
1210 1220 1230 1240 1250
WRIKQLGSHS PVALLNTLFY FNTKYFGLKT VEQHLRLSFG TVFRHWKKNP
1260 1270 1280 1290 1300
LTMENKACLR YQVSSLCGTD NEDKIATGKR KHEDDEPVFE QVENTANPSR
1310 1320 1330 1340 1350
CPVKMFECYL SKSPQNLNQR MDVFYLQPEC SSSTDSPVWY TSTSLDRNTL
1360 1370
ENMLVRVLLV KDIYDKDNYE LDEDTD
Length:1,376
Mass (Da):154,642
Last modified:January 9, 2007 - v3
Checksum:i1D4955422F0646B4
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A286YCD5A0A286YCD5_MOUSE
Zinc finger MYM-type protein 2
Zmym2
290Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017929 mRNA Translation: BAB31008.1
AK135499 mRNA Translation: BAE22556.1
AK137708 mRNA Translation: BAE23471.1
AK137720 mRNA Translation: BAE23475.1
BC043450 mRNA Translation: AAH43450.1
BC141403 mRNA Translation: AAI41404.1
CCDSiCCDS49506.1
RefSeqiNP_083774.2, NM_029498.3
XP_006519728.1, XM_006519665.3
XP_017171710.1, XM_017316221.1
UniGeneiMm.31417
Mm.486624

Genome annotation databases

EnsembliENSMUST00000022511; ENSMUSP00000022511; ENSMUSG00000021945
GeneIDi76007
KEGGimmu:76007
UCSCiuc007ucs.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017929 mRNA Translation: BAB31008.1
AK135499 mRNA Translation: BAE22556.1
AK137708 mRNA Translation: BAE23471.1
AK137720 mRNA Translation: BAE23475.1
BC043450 mRNA Translation: AAH43450.1
BC141403 mRNA Translation: AAI41404.1
CCDSiCCDS49506.1
RefSeqiNP_083774.2, NM_029498.3
XP_006519728.1, XM_006519665.3
XP_017171710.1, XM_017316221.1
UniGeneiMm.31417
Mm.486624

3D structure databases

ProteinModelPortaliQ9CU65
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi217903, 12 interactors
DIPiDIP-29928N
IntActiQ9CU65, 3 interactors
MINTiQ9CU65
STRINGi10090.ENSMUSP00000022511

PTM databases

iPTMnetiQ9CU65
PhosphoSitePlusiQ9CU65

Proteomic databases

EPDiQ9CU65
MaxQBiQ9CU65
PaxDbiQ9CU65
PeptideAtlasiQ9CU65
PRIDEiQ9CU65

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022511; ENSMUSP00000022511; ENSMUSG00000021945
GeneIDi76007
KEGGimmu:76007
UCSCiuc007ucs.1 mouse

Organism-specific databases

CTDi7750
MGIiMGI:1923257 Zmym2

Phylogenomic databases

eggNOGiENOG410IE8I Eukaryota
ENOG410XQR6 LUCA
GeneTreeiENSGT00550000074408
HOGENOMiHOG000293258
HOVERGENiHBG057545
InParanoidiQ9CU65
OMAiAYGVNAW
OrthoDBiEOG091G00KQ
PhylomeDBiQ9CU65
TreeFamiTF336988

Miscellaneous databases

ChiTaRSiZmym2 mouse
PROiPR:Q9CU65
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021945 Expressed in 243 organ(s), highest expression level in pes
CleanExiMM_ZMYM2
ExpressionAtlasiQ9CU65 baseline and differential
GenevisibleiQ9CU65 MM

Family and domain databases

InterProiView protein in InterPro
IPR021893 DUF3504
IPR026625 TFII-I-rel
IPR011017 TRASH_dom
IPR010507 Znf_MYM
PANTHERiPTHR11697 PTHR11697, 1 hit
PfamiView protein in Pfam
PF12012 DUF3504, 1 hit
PF06467 zf-FCS, 8 hits
SMARTiView protein in SMART
SM00746 TRASH, 9 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZMYM2_MOUSE
AccessioniPrimary (citable) accession number: Q9CU65
Secondary accession number(s): B2RUS2
, Q3UUZ8, Q3UXK7, Q80XP0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: January 9, 2007
Last modified: November 7, 2018
This is version 134 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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