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Protein

Protein SIX6OS1

Gene

Six6os1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Meiotic protein that localizes to the central element of the synaptonemal complex and is required for chromosome synapsis during meiotic recombination (PubMed:27796301). Required for the appropriate processing of intermediate recombination nodules before crossover formation (PubMed:27796301).1 Publication

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDNA recombination, Meiosis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SIX6OS1
Alternative name(s):
Six6 opposite strand transcript 1 homolog
Gene namesi
Name:Six6os1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1923051 4930447C04Rik

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome

Pathology & Biotechi

Disruption phenotypei

Mice develop normally but males and females are sterile due to defects in chromosome synapsis at meiotic prophase I (PubMed:27796301). Spermatogenesis proceeds normally up to prophase I until a massive apoptosis of spermatocytes takes place at stage IV (PubMed:27796301). Ovaries of female mice at 4 months of age display a lack of oocytes (PubMed:27796301).1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000898891 – 574Protein SIX6OS1Add BLAST574

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei427PhosphothreonineCombined sources1
Modified residuei430PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9CTN5
PRIDEiQ9CTN5

PTM databases

iPTMnetiQ9CTN5
PhosphoSitePlusiQ9CTN5

Expressioni

Tissue specificityi

Most abundantly expressed in testis (PubMed:27796301). Also expressed in retina and skeletal muscle (PubMed:15703187).2 Publications

Gene expression databases

BgeeiENSMUSG00000021098 Expressed in 126 organ(s), highest expression level in female gonad
CleanExiMM_SIX6OS1
ExpressionAtlasiQ9CTN5 baseline and differential
GenevisibleiQ9CTN5 MM

Interactioni

Subunit structurei

Interacts with SYCE1 (PubMed:27796301).1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035376

Structurei

3D structure databases

ProteinModelPortaliQ9CTN5
SMRiQ9CTN5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi556 – 565Poly-Ser10

Phylogenomic databases

eggNOGiENOG410IJEE Eukaryota
ENOG410Y2YA LUCA
GeneTreeiENSGT00390000010439
HOGENOMiHOG000154240
HOVERGENiHBG082423
InParanoidiQ9CTN5
PhylomeDBiQ9CTN5
TreeFamiTF337593

Family and domain databases

InterProiView protein in InterPro
IPR031380 SIX6OS1
PANTHERiPTHR35449 PTHR35449, 1 hit
PfamiView protein in Pfam
PF15676 S6OS1, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9CTN5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNDNLFVSLD RLLLEFVFQY EQDISIKEDT IQRINKCLES IKENKANVSK
60 70 80 90 100
LREAINKVDE DIAFHYKHSK EIKDSCSNWK PTCDVFHKHE DYIKDQLTAY
110 120 130 140 150
QETNEKDKKM YHDYICQYED VLKQYQLKYS ETRFSCKYYE KKKEHEEIKN
160 170 180 190 200
RVLACTEQLQ LNETILMKFL VPAPFPSLTK WTLYVVNLRY RTQDILKRAN
210 220 230 240 250
NFTKRSFELE KEADDMEIEI NSLNKMARLF ESKTFSEALD EKNKNTEKRK
260 270 280 290 300
EFEERIFEKD EQVSNRSSQN SQLLLPCESQ KFVRNMNSSE ARVTDKKEES
310 320 330 340 350
SANQSKFVRS DVRQKENNPQ IFNDSGMDSN SKSSHIPAVK SSQGFMQFRL
360 370 380 390 400
NQPNYNQRIE KEHIDAECGD KETVRQVRES KCSTQALYIE HFGKSIENNS
410 420 430 440 450
VEEERDENFP QTPETPSFLR TPEALKTPES MEKMQFPKSP FFEITKNATS
460 470 480 490 500
EGHKQKDSPG FSFLMSYTSR SPGLNLFDSS VSDSEISSDQ FNEHYSAVNL
510 520 530 540 550
NPSSSQQGIG NLFGKSEGED AFTFSFSSDS SHTFGAGKDD FSFPFSFEQD
560 570
PSTMTSSSSK DFSSSQNKTQ FMFF
Note: No experimental confirmation available.
Length:574
Mass (Da):66,867
Last modified:April 11, 2003 - v2
Checksum:i4BAE05EAF4A3DB43
GO
Isoform 2 (identifier: Q9CTN5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     186-203: VNLRYRTQDILKRANNFT → YPQQISLIIFLDKYNLRF
     204-574: Missing.

Note: No experimental confirmation available.
Show »
Length:203
Mass (Da):24,613
Checksum:i6A2E1BA13F1A4330
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WHJ9F8WHJ9_MOUSE
RIKEN cDNA 4930447C04 gene
4930447C04Rik
575Annotation score:
D3YUI5D3YUI5_MOUSE
RIKEN cDNA 4930447C04 gene
4930447C04Rik
107Annotation score:
D3YZ78D3YZ78_MOUSE
RIKEN cDNA 4930447C04 gene
4930447C04Rik
143Annotation score:
F7BAS9F7BAS9_MOUSE
RIKEN cDNA 4930447C04 gene
4930447C04Rik
71Annotation score:
D3Z202D3Z202_MOUSE
RIKEN cDNA 4930447C04 gene
4930447C04Rik
88Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_007121186 – 203VNLRY…ANNFT → YPQQISLIIFLDKYNLRF in isoform 2. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_007122204 – 574Missing in isoform 2. 1 PublicationAdd BLAST371

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014811 mRNA Translation: BAB29563.1
AK015397 mRNA Translation: BAB29829.1
AK020932 mRNA Translation: BAB32260.1
CCDSiCCDS25971.1 [Q9CTN5-1]
RefSeqiNP_083720.1, NM_029444.2 [Q9CTN5-1]
UniGeneiMm.242892

Genome annotation databases

EnsembliENSMUST00000044000; ENSMUSP00000035376; ENSMUSG00000021098 [Q9CTN5-1]
ENSMUST00000131033; ENSMUSP00000119777; ENSMUSG00000021098 [Q9CTN5-2]
GeneIDi75801
KEGGimmu:75801
UCSCiuc007nvv.1 mouse [Q9CTN5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014811 mRNA Translation: BAB29563.1
AK015397 mRNA Translation: BAB29829.1
AK020932 mRNA Translation: BAB32260.1
CCDSiCCDS25971.1 [Q9CTN5-1]
RefSeqiNP_083720.1, NM_029444.2 [Q9CTN5-1]
UniGeneiMm.242892

3D structure databases

ProteinModelPortaliQ9CTN5
SMRiQ9CTN5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035376

PTM databases

iPTMnetiQ9CTN5
PhosphoSitePlusiQ9CTN5

Proteomic databases

PaxDbiQ9CTN5
PRIDEiQ9CTN5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044000; ENSMUSP00000035376; ENSMUSG00000021098 [Q9CTN5-1]
ENSMUST00000131033; ENSMUSP00000119777; ENSMUSG00000021098 [Q9CTN5-2]
GeneIDi75801
KEGGimmu:75801
UCSCiuc007nvv.1 mouse [Q9CTN5-1]

Organism-specific databases

MGIiMGI:1923051 4930447C04Rik

Phylogenomic databases

eggNOGiENOG410IJEE Eukaryota
ENOG410Y2YA LUCA
GeneTreeiENSGT00390000010439
HOGENOMiHOG000154240
HOVERGENiHBG082423
InParanoidiQ9CTN5
PhylomeDBiQ9CTN5
TreeFamiTF337593

Miscellaneous databases

ChiTaRSi4930447C04Rik mouse
PROiPR:Q9CTN5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021098 Expressed in 126 organ(s), highest expression level in female gonad
CleanExiMM_SIX6OS1
ExpressionAtlasiQ9CTN5 baseline and differential
GenevisibleiQ9CTN5 MM

Family and domain databases

InterProiView protein in InterPro
IPR031380 SIX6OS1
PANTHERiPTHR35449 PTHR35449, 1 hit
PfamiView protein in Pfam
PF15676 S6OS1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS6OS1_MOUSE
AccessioniPrimary (citable) accession number: Q9CTN5
Secondary accession number(s): Q9D5F5, Q9D5Y9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: April 11, 2003
Last modified: September 12, 2018
This is version 100 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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