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Protein

Rho-related BTB domain-containing protein 3

Gene

Rhobtb3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Rab9-regulated ATPase required for endosome to Golgi transport. Involved in transport vesicle docking at the Golgi complex, possibly by participating in release M6PRBP1/TIP47 from vesicles to permit their efficient docking and fusion at the Golgi. Specifically binds Rab9, but not other Rab proteins. Has low intrinsic ATPase activity due to autoinhibition, which is relieved by Rab9 (By similarity).By similarity

GO - Molecular functioni

  • ATPase activity Source: UniProtKB
  • ATP binding Source: UniProtKB
  • GTPase activity Source: GO_Central
  • GTP binding Source: GO_Central
  • protein kinase binding Source: GO_Central
  • Rab GTPase binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-6811440 Retrograde transport at the Trans-Golgi-Network

Names & Taxonomyi

Protein namesi
Recommended name:
Rho-related BTB domain-containing protein 3 (EC:3.6.1.-)
Gene namesi
Name:Rhobtb3
Synonyms:Kiaa0878
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1920546 Rhobtb3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001989651 – 611Rho-related BTB domain-containing protein 3Add BLAST611

Proteomic databases

MaxQBiQ9CTN4
PaxDbiQ9CTN4
PRIDEiQ9CTN4

PTM databases

iPTMnetiQ9CTN4
PhosphoSitePlusiQ9CTN4

Expressioni

Gene expression databases

BgeeiENSMUSG00000021589 Expressed in 252 organ(s), highest expression level in pes
CleanExiMM_RHOBTB3
ExpressionAtlasiQ9CTN4 baseline and differential
GenevisibleiQ9CTN4 MM

Interactioni

Subunit structurei

Interacts with RAB9A and RAB9B (at lower level compared to RAB9A-binding). Interacts with M6PRBP1/TIP47 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi215902, 3 interactors
STRINGi10090.ENSMUSP00000022078

Structurei

3D structure databases

ProteinModelPortaliQ9CTN4
SMRiQ9CTN4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini254 – 356BTB 1PROSITE-ProRule annotationAdd BLAST103
Domaini420 – 487BTB 2PROSITE-ProRule annotationAdd BLAST68

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 175Rho-likeAdd BLAST175
Regioni420 – 611Interaction with Rab9By similarityAdd BLAST192

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0393 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00850000132411
HOGENOMiHOG000133048
HOVERGENiHBG079130
InParanoidiQ9CTN4
KOiK07869
OMAiHFIYSGA
OrthoDBiEOG091G034E
PhylomeDBiQ9CTN4
TreeFamiTF323347

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR027417 P-loop_NTPase
IPR031260 RhoBTB3
IPR011333 SKP1/BTB/POZ_sf
IPR001806 Small_GTPase
PANTHERiPTHR24072:SF139 PTHR24072:SF139, 1 hit
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF00071 Ras, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF54695 SSF54695, 2 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9CTN4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSIHIVALGN EGDTFHQDNR PSGLIRTYLG RSPLVSGDES SLLLNAASTV
60 70 80 90 100
ARPVFTEYQA SAFGNVKLVV HDCPVWDIFD SDWYTSRNLI GGADIIVIKY
110 120 130 140 150
NVNDKFSFHE VKDNYIPVIK RASNSVPVII AAVGTRQNEE LPCTCPLCTS
160 170 180 190 200
DRGSCVTTTE GIQLAKELGA TYLELHSLDD FYIGKYFGGV LEYFMIQALN
210 220 230 240 250
QKTSEKMKKR KMTSSFHGIR PPQLEQPEKM PVLKAEASHY HSDLNNLLLC
260 270 280 290 300
CQCVDVVFYH PEVTGVVEAH KIVLCSVSHV FMLLFNVKSP ADIQDSSIIR
310 320 330 340 350
TTQDLFAINR DAVLPGASQE APSNPPLPVI VKDALFCSCL SDILRFIYSG
360 370 380 390 400
AFQWEELEED VRRKLKDSGD VSDIIEKVKC ILKTPGKINC LRNCKTYQAR
410 420 430 440 450
KPLWFYNTSL KFFLNKPMLA DVVFEIQGAT VPAHRAILVA RCEVMAAMFN
460 470 480 490 500
GNYMEAKSVL IPVYGVSKET FLSFLEYLYT DSCCPAGIFQ AMCLLICAEM
510 520 530 540 550
YQVSRLQHIC ELFIITQLQS MPSRELASMN LDIVDLLKKA KFHHSDCLST
560 570 580 590 600
WLLHFIATNY LIFSQKPEFQ DLSVEERSFV EKHRWPSNMY LKQLAEYRKY
610
IHSRKCRCLV M
Length:611
Mass (Da):69,208
Last modified:October 13, 2009 - v3
Checksum:iF053962BD8CA1CDF
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8BV11Q8BV11_MOUSE
Rho-related BTB domain-containing p...
Rhobtb3 Hspg2
260Annotation score:
A0A1Y7VMM2A0A1Y7VMM2_MOUSE
Rho-related BTB domain-containing p...
Rhobtb3
100Annotation score:
A0A1Y7VJQ5A0A1Y7VJQ5_MOUSE
Rho-related BTB domain-containing p...
Rhobtb3
88Annotation score:

Sequence cautioni

The sequence AAH05664 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAC98044 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti588N → H in BAB24689 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129234 mRNA Translation: BAC98044.1 Different initiation.
AK020938 mRNA No translation available.
AK006650 mRNA Translation: BAB24689.1
AK139158 mRNA Translation: BAE23906.1
CH466563 Genomic DNA Translation: EDL37111.1
BC005664 mRNA Translation: AAH05664.1 Sequence problems.
BC050836 mRNA Translation: AAH50836.1
CCDSiCCDS26652.1
RefSeqiNP_082769.1, NM_028493.2
UniGeneiMm.276200

Genome annotation databases

EnsembliENSMUST00000022078; ENSMUSP00000022078; ENSMUSG00000021589
GeneIDi73296
KEGGimmu:73296
UCSCiuc007rfy.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129234 mRNA Translation: BAC98044.1 Different initiation.
AK020938 mRNA No translation available.
AK006650 mRNA Translation: BAB24689.1
AK139158 mRNA Translation: BAE23906.1
CH466563 Genomic DNA Translation: EDL37111.1
BC005664 mRNA Translation: AAH05664.1 Sequence problems.
BC050836 mRNA Translation: AAH50836.1
CCDSiCCDS26652.1
RefSeqiNP_082769.1, NM_028493.2
UniGeneiMm.276200

3D structure databases

ProteinModelPortaliQ9CTN4
SMRiQ9CTN4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi215902, 3 interactors
STRINGi10090.ENSMUSP00000022078

PTM databases

iPTMnetiQ9CTN4
PhosphoSitePlusiQ9CTN4

Proteomic databases

MaxQBiQ9CTN4
PaxDbiQ9CTN4
PRIDEiQ9CTN4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022078; ENSMUSP00000022078; ENSMUSG00000021589
GeneIDi73296
KEGGimmu:73296
UCSCiuc007rfy.1 mouse

Organism-specific databases

CTDi22836
MGIiMGI:1920546 Rhobtb3
RougeiSearch...

Phylogenomic databases

eggNOGiKOG0393 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00850000132411
HOGENOMiHOG000133048
HOVERGENiHBG079130
InParanoidiQ9CTN4
KOiK07869
OMAiHFIYSGA
OrthoDBiEOG091G034E
PhylomeDBiQ9CTN4
TreeFamiTF323347

Enzyme and pathway databases

ReactomeiR-MMU-6811440 Retrograde transport at the Trans-Golgi-Network

Miscellaneous databases

ChiTaRSiRhobtb3 mouse
PROiPR:Q9CTN4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021589 Expressed in 252 organ(s), highest expression level in pes
CleanExiMM_RHOBTB3
ExpressionAtlasiQ9CTN4 baseline and differential
GenevisibleiQ9CTN4 MM

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR027417 P-loop_NTPase
IPR031260 RhoBTB3
IPR011333 SKP1/BTB/POZ_sf
IPR001806 Small_GTPase
PANTHERiPTHR24072:SF139 PTHR24072:SF139, 1 hit
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF00071 Ras, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF54695 SSF54695, 2 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiRHBT3_MOUSE
AccessioniPrimary (citable) accession number: Q9CTN4
Secondary accession number(s): Q05DP2
, Q3UTS4, Q80X55, Q9CVT0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: October 13, 2009
Last modified: November 7, 2018
This is version 124 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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