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Protein

rRNA-processing protein FCF1 homolog

Gene

Fcf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly.By similarity

GO - Biological processi

Keywordsi

Biological processRibosome biogenesis, rRNA processing

Enzyme and pathway databases

ReactomeiR-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
rRNA-processing protein FCF1 homolog
Gene namesi
Name:Fcf1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1920986 Fcf1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000899211 – 198rRNA-processing protein FCF1 homologAdd BLAST198

Proteomic databases

EPDiQ9CTH6
MaxQBiQ9CTH6
PaxDbiQ9CTH6
PRIDEiQ9CTH6

PTM databases

PhosphoSitePlusiQ9CTH6

Expressioni

Gene expression databases

BgeeiENSMUSG00000021243 Expressed in 20 organ(s), highest expression level in female gonad
ExpressionAtlasiQ9CTH6 baseline and differential
GenevisibleiQ9CTH6 MM

Interactioni

Protein-protein interaction databases

BioGridi216221, 1 interactor
STRINGi10090.ENSMUSP00000021669

Structurei

3D structure databases

ProteinModelPortaliQ9CTH6
SMRiQ9CTH6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini67 – 166PINcAdd BLAST100

Sequence similaritiesi

Belongs to the UTP23/FCF1 family. FCF1 subfamily.Curated

Phylogenomic databases

eggNOGiKOG3165 Eukaryota
COG1412 LUCA
GeneTreeiENSGT00550000074979
HOGENOMiHOG000183747
HOVERGENiHBG051022
InParanoidiQ9CTH6
KOiK14566
OMAiRVMQHKC
OrthoDBiEOG091G0KRZ
PhylomeDBiQ9CTH6
TreeFamiTF314992

Family and domain databases

CDDicd09864 PIN_Fcf1, 1 hit
InterProiView protein in InterPro
IPR006984 Fcf1/Utp23
IPR037503 Fcf1_PIN
IPR029060 PIN-like_dom_sf
IPR002716 PIN_dom
PANTHERiPTHR12416 PTHR12416, 1 hit
PfamiView protein in Pfam
PF04900 Fcf1, 1 hit
SMARTiView protein in SMART
SM00670 PINc, 1 hit
SUPFAMiSSF88723 SSF88723, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9CTH6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGKQKKTRKY ATMKRMLSLR DERLKEKDRL KPKKKEKKDP SALKEREVPQ
60 70 80 90 100
HPSCLFFQYN TQLGPPYHIL VDTNFINFSI KAKLDLVQSM MDCLYAKCIP
110 120 130 140 150
CITDCVMAEI EKLGQKFRVA LRIAKDPRFD RLPCTHKGTY ADDCLVQRVT
160 170 180 190
QHKCYIVATV DRDLKRRIRK IPGVPIMYLS NHRYNIERMP DDYGAPRF
Length:198
Mass (Da):23,341
Last modified:September 9, 2003 - v2
Checksum:iFBEC2ABABC12C109
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q186E9Q186_MOUSE
rRNA-processing protein FCF1 homolo...
Fcf1
186Annotation score:

Sequence cautioni

The sequence AAH33045 differs from that shown. Reason: Erroneous termination at position 165. Translated as Lys.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC033045 mRNA Translation: AAH33045.1 Different termination.
BC094619 mRNA No translation available.
AK003561 mRNA Translation: BAB22857.1
CCDSiCCDS49113.1
RefSeqiNP_082908.2, NM_028632.2
UniGeneiMm.341848

Genome annotation databases

EnsembliENSMUST00000021669; ENSMUSP00000021669; ENSMUSG00000021243
GeneIDi73736
KEGGimmu:73736
UCSCiuc007ogc.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC033045 mRNA Translation: AAH33045.1 Different termination.
BC094619 mRNA No translation available.
AK003561 mRNA Translation: BAB22857.1
CCDSiCCDS49113.1
RefSeqiNP_082908.2, NM_028632.2
UniGeneiMm.341848

3D structure databases

ProteinModelPortaliQ9CTH6
SMRiQ9CTH6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi216221, 1 interactor
STRINGi10090.ENSMUSP00000021669

PTM databases

PhosphoSitePlusiQ9CTH6

Proteomic databases

EPDiQ9CTH6
MaxQBiQ9CTH6
PaxDbiQ9CTH6
PRIDEiQ9CTH6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021669; ENSMUSP00000021669; ENSMUSG00000021243
GeneIDi73736
KEGGimmu:73736
UCSCiuc007ogc.2 mouse

Organism-specific databases

CTDi51077
MGIiMGI:1920986 Fcf1

Phylogenomic databases

eggNOGiKOG3165 Eukaryota
COG1412 LUCA
GeneTreeiENSGT00550000074979
HOGENOMiHOG000183747
HOVERGENiHBG051022
InParanoidiQ9CTH6
KOiK14566
OMAiRVMQHKC
OrthoDBiEOG091G0KRZ
PhylomeDBiQ9CTH6
TreeFamiTF314992

Enzyme and pathway databases

ReactomeiR-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

PROiPR:Q9CTH6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021243 Expressed in 20 organ(s), highest expression level in female gonad
ExpressionAtlasiQ9CTH6 baseline and differential
GenevisibleiQ9CTH6 MM

Family and domain databases

CDDicd09864 PIN_Fcf1, 1 hit
InterProiView protein in InterPro
IPR006984 Fcf1/Utp23
IPR037503 Fcf1_PIN
IPR029060 PIN-like_dom_sf
IPR002716 PIN_dom
PANTHERiPTHR12416 PTHR12416, 1 hit
PfamiView protein in Pfam
PF04900 Fcf1, 1 hit
SMARTiView protein in SMART
SM00670 PINc, 1 hit
SUPFAMiSSF88723 SSF88723, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFCF1_MOUSE
AccessioniPrimary (citable) accession number: Q9CTH6
Secondary accession number(s): Q505C6, Q8K261
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 9, 2003
Last sequence update: September 9, 2003
Last modified: November 7, 2018
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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