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Protein

Partitioning defective 3 homolog B

Gene

Pard3b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Putative adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions (By similarity).By similarity

GO - Molecular functioni

  • phosphatidylinositol binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
Partitioning defective 3 homolog B
Alternative name(s):
Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 protein homolog
PAR3-beta
Partitioning defective 3-like protein
Short name:
PAR3-L protein
Gene namesi
Name:Pard3b
Synonyms:Als2cr19, Par3l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1919301 Pard3b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001850731 – 1203Partitioning defective 3 homolog BAdd BLAST1203

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei100PhosphoserineBy similarity1
Modified residuei346PhosphoserineCombined sources1
Modified residuei352PhosphoserineCombined sources1
Modified residuei368PhosphoserineBy similarity1
Modified residuei635PhosphoserineCombined sources1
Modified residuei710PhosphoserineCombined sources1
Modified residuei728PhosphoserineCombined sources1
Modified residuei730PhosphoserineCombined sources1
Modified residuei746PhosphoserineCombined sources1
Modified residuei749PhosphoserineCombined sources1
Modified residuei801PhosphoserineBy similarity1
Modified residuei810PhosphothreonineCombined sources1
Modified residuei1088PhosphoserineCombined sources1
Modified residuei1182PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9CSB4
PRIDEiQ9CSB4

PTM databases

iPTMnetiQ9CSB4
PhosphoSitePlusiQ9CSB4

Expressioni

Gene expression databases

BgeeiENSMUSG00000052062 Expressed in 206 organ(s), highest expression level in blood
ExpressionAtlasiQ9CSB4 baseline and differential
GenevisibleiQ9CSB4 MM

Interactioni

Subunit structurei

Interacts with PARD6B. Interacts with INSC/inscuteable (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Stk11Q9WTK72EBI-16107395,EBI-8627450

Protein-protein interaction databases

DIPiDIP-60855N
IntActiQ9CSB4, 1 interactor
STRINGi10090.ENSMUSP00000074837

Structurei

Secondary structure

11203
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9CSB4
SMRiQ9CSB4
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9CSB4

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini201 – 289PDZ 1PROSITE-ProRule annotationAdd BLAST89
Domaini383 – 468PDZ 2PROSITE-ProRule annotationAdd BLAST86
Domaini496 – 585PDZ 3PROSITE-ProRule annotationAdd BLAST90

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1109 – 1162Pro-richAdd BLAST54

Sequence similaritiesi

Belongs to the PAR3 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410ITA1 Eukaryota
ENOG410ZRQX LUCA
GeneTreeiENSGT00760000119017
HOGENOMiHOG000232109
HOVERGENiHBG053508
InParanoidiQ9CSB4
OrthoDBiEOG091G04AU
PhylomeDBiQ9CSB4
TreeFamiTF323729

Family and domain databases

InterProiView protein in InterPro
IPR021922 Par3/HAL_N
IPR001478 PDZ
IPR036034 PDZ_sf
PfamiView protein in Pfam
PF12053 DUF3534, 1 hit
PF00595 PDZ, 2 hits
SMARTiView protein in SMART
SM00228 PDZ, 3 hits
SUPFAMiSSF50156 SSF50156, 3 hits
PROSITEiView protein in PROSITE
PS50106 PDZ, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9CSB4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKVTVCFGRT GIVVPCKDGQ LRVRELTQQA LQRYLKTRDQ DPGYWVKIHH
60 70 80 90 100
LEYTDGGILD PDDVLADVVE DKDKLIAVFD EQEPLQKTES PGGNPADRQS
110 120 130 140 150
PDAFETEVAA QLAAFKPVGG EIVVTPSALK LGTPLLVRRS SDPAPGPHAD
160 170 180 190 200
AQPSTASLSG QSLKPVVLDS TQNVENKEAM NGEQAGLLSL HRPKDELSDM
210 220 230 240 250
TRAVEISGEG DPLGIHVVPF FSSLSGRILG LFIRGIEENS RCKQEGLFQE
260 270 280 290 300
NECIVKINNV ELLDKTFAQA QDVFRQAMKS PSVILHVLLP QNREQYEKSV
310 320 330 340 350
IGPLNIFGNN DGASRTKAAP PARGKPGLKA VHLTRASSPE GEEPASPQQS
360 370 380 390 400
KSPRVPRLGR KPSSPSLSPL MGFGSKKNAK KIKIDLKKGP EGLGFTVVTR
410 420 430 440 450
DSSIHGPGPI FVKNILPKGA AVKDGRLQSG DRILEVNGRD VTGRTQEELV
460 470 480 490 500
AMLRSTKQGE TVSLVIARQE GSFLPRELKG EPDCYALSLE SSEQLTLEIP
510 520 530 540 550
LNDSGSAGLG VSLKGNKSRE TGTDLGIFIK SIIHGGAAFK DGRLRMNDQL
560 570 580 590 600
IAVNGETLLG KSNHEAMETL RRSMSMEGNI RGMIQLVILR RPERPLEELS
610 620 630 640 650
ECGALSRPGF ENCQEALSTS RRNDSSILYP FGTYSPQDKR KDLLLPSDGW
660 670 680 690 700
AENEVPPSPP PHPALEWGLE DFSHSSGVDS TGYFPDQHVN FRTVTPVRQP
710 720 730 740 750
ELINLKASKS MDLVPDEGKV QSLADRRSDS PGKDFGPTLG LKKSSSLESL
760 770 780 790 800
QTAVAEVRKN DLPFHRPRPH MVRGRGCNES FRAAIDKSYD GPEEADADGL
810 820 830 840 850
SDKSSRSGHT ALNCESAPQG NPELDNVENK AKNIKKTKEK EKKKGKGKLK
860 870 880 890 900
VKEKKLKEEH EDAERKMKRK GFGAMLRFGK KKDDKVGKAE QKGAQKSGHP
910 920 930 940 950
EEEELERMKE ERERIGAKHQ ELREKQARGL VDYATAVTGP VHDMDDDEMD
960 970 980 990 1000
PNYARVNHFR EPCASANVFR SPSPLRAGPL AYPRDGRPLS PDHLEGLYAK
1010 1020 1030 1040 1050
VNKPYHPPAL ADSGRPMAGT TDRIQKLRKE YYQARREGFL LYEDENTRAR
1060 1070 1080 1090 1100
PSDHDLRWVS GKGPDGSTHN LRFEGMERQY ASLPRGGSAD PVDYLTASPR
1110 1120 1130 1140 1150
GRYNDRELPY YPGPHPVHAP RGSYPRPPDL RATDLRYPQY YPPPPAHQHK
1160 1170 1180 1190 1200
GPFRQDVPPS PPQHQRVPVY QEMGRAGPRG SSPDQYPYRN QDPRQKNPMT

AAV
Length:1,203
Mass (Da):132,780
Last modified:December 12, 2006 - v2
Checksum:i7A9D63ED45BD3109
GO
Isoform 2 (identifier: Q9CSB4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     169-213: DSTQNVENKE...VEISGEGDPL → RTLIGNSSSG...TENKIKTFKD

Note: Sequence incomplete. No experimental confirmation available.
Show »
Length:1,203
Mass (Da):133,086
Checksum:iAE3A8004B99D4CAB
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5SV54Q5SV54_MOUSE
Ortholog of human amyotrophic later...
Pard3b Als2cr19, RP23-20G7.1, RP23-20G7.1-003
1,104Annotation score:
Q5SV55Q5SV55_MOUSE
Ortholog of human amyotrophic later...
Pard3b Als2cr19, RP23-20G7.1, RP23-20G7.1-002
1,141Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_022017169 – 213DSTQN…EGDPL → RTLIGNSSSGEFSALFWLLW ALHSCAWINTHSKHITENKI KTFKD in isoform 2. 1 PublicationAdd BLAST45

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645727
, AL662815, AL645669, AL645544, AL662920 Genomic DNA Translation: CAI24504.1
AL645669
, AL662920, AL662815, AL645727, AL645544 Genomic DNA Translation: CAI24824.1
AL645544
, AL645669, AL645727, AL662815, AL662920 Genomic DNA Translation: CAI25199.1
AL662815
, AL645544, AL645669, AL645727, AL662920 Genomic DNA Translation: CAI25349.1
AL662920
, AL645544, AL645669, AL645727, AL662815 Genomic DNA Translation: CAI26112.1
AK013352 mRNA Translation: BAB28805.1
CCDSiCCDS48276.1 [Q9CSB4-1]
RefSeqiNP_001074519.2, NM_001081050.2 [Q9CSB4-1]
UniGeneiMm.35153
Mm.441881

Genome annotation databases

EnsembliENSMUST00000075374; ENSMUSP00000074837; ENSMUSG00000052062 [Q9CSB4-1]
GeneIDi72823
KEGGimmu:72823
UCSCiuc007bfe.2 mouse [Q9CSB4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645727
, AL662815, AL645669, AL645544, AL662920 Genomic DNA Translation: CAI24504.1
AL645669
, AL662920, AL662815, AL645727, AL645544 Genomic DNA Translation: CAI24824.1
AL645544
, AL645669, AL645727, AL662815, AL662920 Genomic DNA Translation: CAI25199.1
AL662815
, AL645544, AL645669, AL645727, AL662920 Genomic DNA Translation: CAI25349.1
AL662920
, AL645544, AL645669, AL645727, AL662815 Genomic DNA Translation: CAI26112.1
AK013352 mRNA Translation: BAB28805.1
CCDSiCCDS48276.1 [Q9CSB4-1]
RefSeqiNP_001074519.2, NM_001081050.2 [Q9CSB4-1]
UniGeneiMm.35153
Mm.441881

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WG6NMR-A478-591[»]
ProteinModelPortaliQ9CSB4
SMRiQ9CSB4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60855N
IntActiQ9CSB4, 1 interactor
STRINGi10090.ENSMUSP00000074837

PTM databases

iPTMnetiQ9CSB4
PhosphoSitePlusiQ9CSB4

Proteomic databases

PaxDbiQ9CSB4
PRIDEiQ9CSB4

Protocols and materials databases

DNASUi72823
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000075374; ENSMUSP00000074837; ENSMUSG00000052062 [Q9CSB4-1]
GeneIDi72823
KEGGimmu:72823
UCSCiuc007bfe.2 mouse [Q9CSB4-1]

Organism-specific databases

CTDi117583
MGIiMGI:1919301 Pard3b

Phylogenomic databases

eggNOGiENOG410ITA1 Eukaryota
ENOG410ZRQX LUCA
GeneTreeiENSGT00760000119017
HOGENOMiHOG000232109
HOVERGENiHBG053508
InParanoidiQ9CSB4
OrthoDBiEOG091G04AU
PhylomeDBiQ9CSB4
TreeFamiTF323729

Miscellaneous databases

ChiTaRSiPard3b mouse
EvolutionaryTraceiQ9CSB4
PROiPR:Q9CSB4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000052062 Expressed in 206 organ(s), highest expression level in blood
ExpressionAtlasiQ9CSB4 baseline and differential
GenevisibleiQ9CSB4 MM

Family and domain databases

InterProiView protein in InterPro
IPR021922 Par3/HAL_N
IPR001478 PDZ
IPR036034 PDZ_sf
PfamiView protein in Pfam
PF12053 DUF3534, 1 hit
PF00595 PDZ, 2 hits
SMARTiView protein in SMART
SM00228 PDZ, 3 hits
SUPFAMiSSF50156 SSF50156, 3 hits
PROSITEiView protein in PROSITE
PS50106 PDZ, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPAR3L_MOUSE
AccessioniPrimary (citable) accession number: Q9CSB4
Secondary accession number(s): Q5SV53
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: December 12, 2006
Last modified: November 7, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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