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Protein

Filamin-A-interacting protein 1

Gene

Filip1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

By acting through a filamin-A/F-actin axis, it controls the start of neocortical cell migration from the ventricular zone. May be able to induce the degradation of filamin-A.By similarity

GO - Biological processi

  • modification of postsynaptic structure Source: SynGO

Names & Taxonomyi

Protein namesi
Recommended name:
Filamin-A-interacting protein 1
Short name:
FILIP
Gene namesi
Name:Filip1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1917848 Filip1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002345411 – 1211Filamin-A-interacting protein 1Add BLAST1211

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei138PhosphoserineBy similarity1
Modified residuei979PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9CS72
PaxDbiQ9CS72
PeptideAtlasiQ9CS72
PRIDEiQ9CS72

PTM databases

iPTMnetiQ9CS72
PhosphoSitePlusiQ9CS72

Expressioni

Gene expression databases

CleanExiMM_FILIP1

Interactioni

Subunit structurei

Interacts with FLNA. Interacts with RHOD (in GTP-bound form).1 Publication

Protein-protein interaction databases

IntActiQ9CS72, 1 interactor
STRINGi10090.ENSMUSP00000091329

Structurei

3D structure databases

ProteinModelPortaliQ9CS72
SMRiQ9CS72
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili192 – 581Sequence analysisAdd BLAST390
Coiled coili624 – 778Sequence analysisAdd BLAST155

Sequence similaritiesi

Belongs to the FILIP1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFP9 Eukaryota
ENOG410ZUI9 LUCA
HOVERGENiHBG053840
InParanoidiQ9CS72
PhylomeDBiQ9CS72

Family and domain databases

InterProiView protein in InterPro
IPR019131 Cortactin-binding_p2_N
PfamiView protein in Pfam
PF09727 CortBP2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9CS72-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRSRNQGGES SSNGHVSCPK PSIISSDGGK GPSEDAKKNK ANRKGEDDVM
60 70 80 90 100
ASGTVKRHLK PSGESEKKTK KPLELSKEDL IQLLSIMEGE LQAREDVIHM
110 120 130 140 150
LKTEKTKPEV LEAHYGSAEP EKVLRVLHRD AILAQEKSIG EDVYEKPISE
160 170 180 190 200
LDRLEEKQKE TYRRMLEQLL LAEKCHRRTV YELENEKHKH TDYMNKSDDF
210 220 230 240 250
TNLLEQERER LKKLLEQEKA YQARKEKENA KRLNKLRDEL VKLKSFALML
260 270 280 290 300
VDERQMHIEQ LGLQSQKVQD LTQKLREEEE KLKAITYKSK EDRQKLLKLE
310 320 330 340 350
VDFEHKASRF SQEHEEMNAK LANQESHNRQ LRLKLVGLSQ RIEELEETNK
360 370 380 390 400
SLQKAEEELQ ELRDKIAKGE CGNSSLMAEV ESLRKRVLEM EGKDEEITKT
410 420 430 440 450
EAQCRELKKK LQEEEHHSKE LRLEVEKLQK RMSELEKLEE AFSRSKSECT
460 470 480 490 500
QLHLNLEKEK NLTKDLLNEL EVVKSRVKEL ECSESRLEKV ELSLKDDLTK
510 520 530 540 550
LKSFTVMLVD ERKNMMEKIK QEERKVDGLN KNFKVEQGKV MDVTEKLIEE
560 570 580 590 600
SKKLLKLKSE MEEKVYSLTK ERDELMGKLR SEEERSCELS CSVDLLKKRL
610 620 630 640 650
DGIEEVEREI NRGRLCKGSE FTCPEDNKIR ELTLEIERLK KRLQQLEVVE
660 670 680 690 700
GDLMKTEDEY DQLEQKFRTE QDKANFLSQQ LEEIKHQMAK NKAIEKGEAV
710 720 730 740 750
SQEAELRHRF RMEEAKSRDL QAEVQALKEK IHELMNKEDQ LSQLQVDYSV
760 770 780 790 800
LQQRFMEEET KNKNMGREVL NLTKELELSK RYSRALRPSG NGRRMVDVPV
810 820 830 840 850
ASTGVQTEAV CGDAAEEETP AVFIRKSFQE ENHIMSNLRQ VGLKKPMERS
860 870 880 890 900
SVLDRYPPAA NELTMRKSWI PWMRKRENGP SAPQEKGPRP NQGTGHPGEL
910 920 930 940 950
VLAPKQGQPL HIRVTPDHEN STATLEITSP TSEEFFSSTT VIPTLGNQKP
960 970 980 990 1000
RITIIPSPNV MSQKPKSADP TLGPERAMSP VTITTISREK SPEGGRGAFA
1010 1020 1030 1040 1050
DRPASPIQIM TVSTSAAPPE IAVSPDSQEV PMGRTILKVT PEKQTVPTPM
1060 1070 1080 1090 1100
RKYNANANII TTEDNKIHIH LGSQFKRSPG PAAAEGVSPV ITVRPVNVTA
1110 1120 1130 1140 1150
EKEVSTGTVL RSPRNHLSSR PGANKVTSTI TITPVTTSST RGTSGQDGSS
1160 1170 1180 1190 1200
QRPTPTRIPM SKGMKAGKPV VAAPGAGNLT KFQPRAETQS MKIELKKSAA
1210
SSTASLGGGK G
Length:1,211
Mass (Da):137,599
Last modified:May 16, 2006 - v2
Checksum:i47C07842F052FA1C
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q059P4Q059P4_MOUSE
Filamin-A-interacting protein 1
Filip1 mCG_18834
1,214Annotation score:
G3UZB6G3UZB6_MOUSE
Filamin-A-interacting protein 1
Filip1
225Annotation score:
A0A1L1SQQ4A0A1L1SQQ4_MOUSE
Filamin-A-interacting protein 1
Filip1
51Annotation score:

Sequence cautioni

The sequence BAB30888 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC140247 Genomic DNA No translation available.
AC127318 Genomic DNA No translation available.
AK017709 mRNA Translation: BAB30888.1 Different initiation.
UniGeneiMm.23049

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC140247 Genomic DNA No translation available.
AC127318 Genomic DNA No translation available.
AK017709 mRNA Translation: BAB30888.1 Different initiation.
UniGeneiMm.23049

3D structure databases

ProteinModelPortaliQ9CS72
SMRiQ9CS72
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9CS72, 1 interactor
STRINGi10090.ENSMUSP00000091329

PTM databases

iPTMnetiQ9CS72
PhosphoSitePlusiQ9CS72

Proteomic databases

MaxQBiQ9CS72
PaxDbiQ9CS72
PeptideAtlasiQ9CS72
PRIDEiQ9CS72

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1917848 Filip1

Phylogenomic databases

eggNOGiENOG410IFP9 Eukaryota
ENOG410ZUI9 LUCA
HOVERGENiHBG053840
InParanoidiQ9CS72
PhylomeDBiQ9CS72

Miscellaneous databases

ChiTaRSiFilip1 mouse
PROiPR:Q9CS72
SOURCEiSearch...

Gene expression databases

CleanExiMM_FILIP1

Family and domain databases

InterProiView protein in InterPro
IPR019131 Cortactin-binding_p2_N
PfamiView protein in Pfam
PF09727 CortBP2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFLIP1_MOUSE
AccessioniPrimary (citable) accession number: Q9CS72
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 16, 2006
Last modified: November 7, 2018
This is version 80 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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