UniProtKB - Q9CS00 (CATIN_MOUSE)
Protein
Cactin
Gene
Cactin
Organism
Mus musculus (Mouse)
Status
Functioni
Involved in the regulation of innate immune response (By similarity). Acts as negative regulator of Toll-like receptor, interferon-regulatory factor (IRF) and canonical NF-kappa-B signaling pathways (By similarity). Contributes to the regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli (By similarity).By similarity
GO - Biological processi
- cellular response to interleukin-1 Source: UniProtKB
- cellular response to lipopolysaccharide Source: UniProtKB
- cellular response to tumor necrosis factor Source: UniProtKB
- innate immune response Source: UniProtKB-KW
- mRNA cis splicing, via spliceosome Source: GO_Central
- multicellular organism development Source: UniProtKB-KW
- negative regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
- negative regulation of innate immune response Source: GO_Central
- negative regulation of interferon-beta production Source: UniProtKB
- negative regulation of interleukin-8 production Source: UniProtKB
- negative regulation of lipopolysaccharide-mediated signaling pathway Source: UniProtKB
- negative regulation of NF-kappaB transcription factor activity Source: UniProtKB
- negative regulation of protein phosphorylation Source: UniProtKB
- negative regulation of toll-like receptor signaling pathway Source: UniProtKB
- negative regulation of tumor necrosis factor production Source: UniProtKB
- negative regulation of type I interferon-mediated signaling pathway Source: UniProtKB
- regulation of gene expression Source: GO_Central
Keywordsi
Molecular function | Developmental protein |
Biological process | Immunity, Innate immunity, mRNA processing, mRNA splicing |
Names & Taxonomyi
Protein namesi | Recommended name: Cactin |
Gene namesi | Name:Cactin |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1917562, Cactin |
Subcellular locationi
Cytosol
- cytosol Source: MGI
Nucleus
- catalytic step 2 spliceosome Source: MGI
- nuclear speck Source: MGI
- nucleoplasm Source: MGI
- nucleus Source: UniProtKB
- spliceosomal complex Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, Nucleus, SpliceosomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000231618 | 1 – 772 | CactinAdd BLAST | 772 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 148 | PhosphoserineCombined sources | 1 | |
Cross-linki | 491 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 498 | PhosphoserineBy similarity | 1 | |
Cross-linki | 506 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 573 | PhosphotyrosineBy similarity | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q9CS00 |
jPOSTi | Q9CS00 |
MaxQBi | Q9CS00 |
PaxDbi | Q9CS00 |
PRIDEi | Q9CS00 |
PTM databases
iPTMneti | Q9CS00 |
PhosphoSitePlusi | Q9CS00 |
Expressioni
Tissue specificityi
Expressed in cortex, hippocampus, cerebellum, heart, lung, kidney, liver, spleen and thymus.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000034889, Expressed in embryo and 259 other tissues |
Genevisiblei | Q9CS00, MM |
Interactioni
Subunit structurei
Interacts (via N-terminal domain) with NFKBIL1; the interaction occurs in a proinflammatory-independent manner (By similarity). Does not interact with RELA NF-kappa-B subunit (By similarity). Identified in the spliceosome C complex (By similarity).
By similarityProtein-protein interaction databases
BioGRIDi | 213980, 28 interactors |
IntActi | Q9CS00, 1 interactor |
MINTi | Q9CS00 |
STRINGi | 10090.ENSMUSP00000059533 |
Miscellaneous databases
RNActi | Q9CS00, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 157 – 207 | Sequence analysisAdd BLAST | 51 | |
Coiled coili | 247 – 299 | Sequence analysisAdd BLAST | 53 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 2 – 101 | Arg-richAdd BLAST | 100 |
Sequence similaritiesi
Belongs to the CACTIN family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG2370, Eukaryota |
GeneTreei | ENSGT00950000183102 |
HOGENOMi | CLU_011759_0_0_1 |
InParanoidi | Q9CS00 |
OMAi | CLIRFMA |
OrthoDBi | 1252926at2759 |
PhylomeDBi | Q9CS00 |
TreeFami | TF300906 |
Family and domain databases
InterProi | View protein in InterPro IPR019134, Cactin_C IPR018816, Cactin_central |
Pfami | View protein in Pfam PF10312, Cactin_mid, 1 hit PF09732, CactinC_cactus, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9CS00-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRGAGRQMGR DSRSRSRSVG RRGRKQRSRS RGRSRSRSRS RSRSRSRSRS
60 70 80 90 100
RSRSHGRSSR RRREHERRRE RKRRSRGRRS DSEGEQRQKS RRRSQSLRPP
110 120 130 140 150
RWHSQNQSSC SDSGEERAQG SWARKGHRRS WSPGSSASSL DSPRRSRSPG
160 170 180 190 200
TATLALSQQQ SLQERLRLRE ERKQQEELLK AFETPEEKRA RRLAKKEAKE
210 220 230 240 250
RKKREKMGWG EEYMGYTNTD NPFGDNNLLG TFIWNKALEK KGISHLEEKE
260 270 280 290 300
LKERNKRIQE DNRLELQKVK QLRLEREREK AMREQELELL QREKEAEHFK
310 320 330 340 350
TWEEQEDSFH LRQAKLRSKI RIRDGRAKPI DLLAKYISAE DDDLAVEMHE
360 370 380 390 400
PYTFLNGLTV ADMEDLLEDI QVYMELEQGK NVDFWRDMTT ITEDEIAKLR
410 420 430 440 450
KLEASGKGPG ERREGVNASV SSDVQSVFKG KTYNQLQVIF QGIEGKIRAG
460 470 480 490 500
GPNLDMGYWE SLLQQLRAHM ARARLRERHQ DVLRQKLFKL KQEQGVESEP
510 520 530 540 550
LFPILKSEPS AAHSPEPEER PPSPGTSVDP VEPVEPEEAT APGEAEGEAE
560 570 580 590 600
GEAVLMEEDL IQQSLADYDA GRYSPRLLTA HELPLDAHVL EPHEDLQRLQ
610 620 630 640 650
LSRQQLQATG DASESAEDIF FRRAREGMGQ DEAQFSVEMP LGGRAYLWAD
660 670 680 690 700
KYRPRKPRFF NRVHTGFEWN KYNQTHYDFD NPPPKIVQGY KFNIFYPDLI
710 720 730 740 750
RKRATPEYFL EACADNRDFA ILRFHAGPPY EDIAFKIVSR EWEYSHRHGF
760 770
RCQFANGIFQ LWFHFKRYRY RR
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A1W2P6J2 | A0A1W2P6J2_MOUSE | Cactin | Cactin | 222 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC155937 Genomic DNA No translation available. AK010963 mRNA Translation: BAB27295.1 |
CCDSi | CCDS35995.1 |
RefSeqi | NP_081657.1, NM_027381.2 |
Genome annotation databases
Ensembli | ENSMUST00000050867; ENSMUSP00000059533; ENSMUSG00000034889 |
GeneIDi | 70312 |
KEGGi | mmu:70312 |
UCSCi | uc007ghf.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC155937 Genomic DNA No translation available. AK010963 mRNA Translation: BAB27295.1 |
CCDSi | CCDS35995.1 |
RefSeqi | NP_081657.1, NM_027381.2 |
3D structure databases
SMRi | Q9CS00 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 213980, 28 interactors |
IntActi | Q9CS00, 1 interactor |
MINTi | Q9CS00 |
STRINGi | 10090.ENSMUSP00000059533 |
PTM databases
iPTMneti | Q9CS00 |
PhosphoSitePlusi | Q9CS00 |
Proteomic databases
EPDi | Q9CS00 |
jPOSTi | Q9CS00 |
MaxQBi | Q9CS00 |
PaxDbi | Q9CS00 |
PRIDEi | Q9CS00 |
Protocols and materials databases
Antibodypediai | 52584, 82 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000050867; ENSMUSP00000059533; ENSMUSG00000034889 |
GeneIDi | 70312 |
KEGGi | mmu:70312 |
UCSCi | uc007ghf.2, mouse |
Organism-specific databases
CTDi | 58509 |
MGIi | MGI:1917562, Cactin |
Phylogenomic databases
eggNOGi | KOG2370, Eukaryota |
GeneTreei | ENSGT00950000183102 |
HOGENOMi | CLU_011759_0_0_1 |
InParanoidi | Q9CS00 |
OMAi | CLIRFMA |
OrthoDBi | 1252926at2759 |
PhylomeDBi | Q9CS00 |
TreeFami | TF300906 |
Miscellaneous databases
BioGRID-ORCSi | 70312, 5 hits in 18 CRISPR screens |
ChiTaRSi | Cactin, mouse |
PROi | PR:Q9CS00 |
RNActi | Q9CS00, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000034889, Expressed in embryo and 259 other tissues |
Genevisiblei | Q9CS00, MM |
Family and domain databases
InterProi | View protein in InterPro IPR019134, Cactin_C IPR018816, Cactin_central |
Pfami | View protein in Pfam PF10312, Cactin_mid, 1 hit PF09732, CactinC_cactus, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CATIN_MOUSE | |
Accessioni | Q9CS00Primary (citable) accession number: Q9CS00 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 4, 2006 |
Last sequence update: | April 4, 2006 | |
Last modified: | February 10, 2021 | |
This is version 116 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families