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Protein

Exportin-T

Gene

Xpot

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the tRNA from the export receptor. XPOT then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity).By similarity

GO - Molecular functioni

  • Ran GTPase binding Source: GO_Central
  • tRNA binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionRNA-binding, tRNA-binding
Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Exportin-T
Alternative name(s):
Exportin(tRNA)
tRNA exportin
Gene namesi
Name:Xpot
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1920442 Xpot

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002047171 – 963Exportin-TAdd BLAST963

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei635N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9CRT8
MaxQBiQ9CRT8
PaxDbiQ9CRT8
PeptideAtlasiQ9CRT8
PRIDEiQ9CRT8

PTM databases

iPTMnetiQ9CRT8
PhosphoSitePlusiQ9CRT8
SwissPalmiQ9CRT8

Expressioni

Gene expression databases

BgeeiENSMUSG00000034667 Expressed in 286 organ(s), highest expression level in urothelium
ExpressionAtlasiQ9CRT8 baseline and differential
GenevisibleiQ9CRT8 MM

Interactioni

Subunit structurei

Found in a complex with XPOT, Ran and tRNA. Probably found in a complex with nucleoporins. Interacts with Ran and tRNA in a GTP-dependent manner (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9CRT8, 5 interactors
MINTiQ9CRT8
STRINGi10090.ENSMUSP00000043488

Structurei

3D structure databases

ProteinModelPortaliQ9CRT8
SMRiQ9CRT8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the exportin family.Curated

Phylogenomic databases

eggNOGiKOG2021 Eukaryota
ENOG410XZDZ LUCA
GeneTreeiENSGT00390000007890
HOGENOMiHOG000007104
HOVERGENiHBG094163
InParanoidiQ9CRT8
OrthoDBiEOG091G04A1
PhylomeDBiQ9CRT8
TreeFamiTF314001

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR013598 Exportin-1/Importin-b-like
IPR001494 Importin-beta_N
IPR040017 XPOT
PANTHERiPTHR15952 PTHR15952, 1 hit
PfamiView protein in Pfam
PF03810 IBN_N, 1 hit
PF08389 Xpo1, 1 hit
SMARTiView protein in SMART
SM00913 IBN_N, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9CRT8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDEQALLGLN PNADSDFRQR ALAYFEQLKI SPDAWQVCAE ALAQKTYSDD
60 70 80 90 100
HVKFFCFQVL EHQVKYKYSE LSTAQQQLIR ETLLSWLQAQ MQNPQPEKTF
110 120 130 140 150
IRNKAAQVFA LLFVTEYLTK WPKFFFDILS VVDLNPRGVD LYLRILMAID
160 170 180 190 200
SELVDRDVVH TSEASGLENT LIKDTMREQC IPNLVESWYQ ILHNYQYTNS
210 220 230 240 250
EVLCQCLEVV GAYVSWIDLS LIANDRFINM LLGHMSVEVL REEACDCLFE
260 270 280 290 300
IVNKGMDPVD KMKLVESLCQ VLQTAGFFSI DQEEDLDFVA RFSKLVNGMG
310 320 330 340 350
QSLIVSWTKL IKNGAVKNAQ EALEAIETKV PLMLQLLVHE DDDISSNIIG
360 370 380 390 400
FCYDYLHILK QLPVLSDQQK ANVEAIMLAV MKKLTYDEEY NFENEGEDEA
410 420 430 440 450
MFVEYRKQLK LLLDRLAQVS PELVLASVRR VFSATLQNWQ TTRFMEVEVA
460 470 480 490 500
VRLLYMLAEA LPVSHGAHFS GDVSKASALQ DMMRTLVTSG VSSYQHTSVT
510 520 530 540 550
LEFFETVVRY EKFFTVEPQH IPCVLMAFLD HRGLWHSSAK VRSRTAYLFS
560 570 580 590 600
RFVKSLNKQM NPYIEEILNR IQDLLALSPP ENGYQSLLSS DDQLFIYETA
610 620 630 640 650
GALIVNSEYP AENKQALMKD LLTPLMERFK VLLEKLMMAQ DEERQASLAD
660 670 680 690 700
SLNHAVGFAS RTSKAFSNKQ TVKQCGCSQV YLDCLQTFLP ALSCPLQKDV
710 720 730 740 750
LRSGVRTFLH RMIICLEEEV LPFIPSASEH MLKDCEAKDL QEFIPLINQI
760 770 780 790 800
TAKFKMQVSP FLQQMFMPLL HAIFEVLLRP AEDNDQSAAL EKQMLRRSYF
810 820 830 840 850
AFLQTVTGSG MSEVIANQGA ENVEQVLVTI IQGAVDYPDP IAQKTCFIIL
860 870 880 890 900
SKLVELWGGK DGPVGFADFV YKHIVPACFL APLKQTFDLA DAQTVLALSE
910 920 930 940 950
CAVTLKTIHL KRGPECVQYL QQEYLPSLQV APEIIQEFCQ ALQQPDAKVF
960
KNYLKVFFQR AKP
Length:963
Mass (Da):109,734
Last modified:January 9, 2007 - v3
Checksum:iEE600F41FBF3A9C8
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2P7Q6A0A1W2P7Q6_MOUSE
Exportin-T
Xpot
962Annotation score:
A0A1W2P7V1A0A1W2P7V1_MOUSE
Exportin-T
Xpot
206Annotation score:
A0A1W2P6G8A0A1W2P6G8_MOUSE
Exportin-T
Xpot
51Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti726S → T in BAB29220 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124992 Genomic DNA No translation available.
BC094337 mRNA Translation: AAH94337.1
AK014235 mRNA Translation: BAB29220.1
UniGeneiMm.25042

Genome annotation databases

EnsembliENSMUST00000039810; ENSMUSP00000043488; ENSMUSG00000034667
UCSCiuc007hfv.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124992 Genomic DNA No translation available.
BC094337 mRNA Translation: AAH94337.1
AK014235 mRNA Translation: BAB29220.1
UniGeneiMm.25042

3D structure databases

ProteinModelPortaliQ9CRT8
SMRiQ9CRT8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9CRT8, 5 interactors
MINTiQ9CRT8
STRINGi10090.ENSMUSP00000043488

PTM databases

iPTMnetiQ9CRT8
PhosphoSitePlusiQ9CRT8
SwissPalmiQ9CRT8

Proteomic databases

EPDiQ9CRT8
MaxQBiQ9CRT8
PaxDbiQ9CRT8
PeptideAtlasiQ9CRT8
PRIDEiQ9CRT8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039810; ENSMUSP00000043488; ENSMUSG00000034667
UCSCiuc007hfv.1 mouse

Organism-specific databases

MGIiMGI:1920442 Xpot

Phylogenomic databases

eggNOGiKOG2021 Eukaryota
ENOG410XZDZ LUCA
GeneTreeiENSGT00390000007890
HOGENOMiHOG000007104
HOVERGENiHBG094163
InParanoidiQ9CRT8
OrthoDBiEOG091G04A1
PhylomeDBiQ9CRT8
TreeFamiTF314001

Miscellaneous databases

PROiPR:Q9CRT8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034667 Expressed in 286 organ(s), highest expression level in urothelium
ExpressionAtlasiQ9CRT8 baseline and differential
GenevisibleiQ9CRT8 MM

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR013598 Exportin-1/Importin-b-like
IPR001494 Importin-beta_N
IPR040017 XPOT
PANTHERiPTHR15952 PTHR15952, 1 hit
PfamiView protein in Pfam
PF03810 IBN_N, 1 hit
PF08389 Xpo1, 1 hit
SMARTiView protein in SMART
SM00913 IBN_N, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiXPOT_MOUSE
AccessioniPrimary (citable) accession number: Q9CRT8
Secondary accession number(s): Q52KI1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: January 9, 2007
Last modified: November 7, 2018
This is version 115 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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