UniProtKB - Q9CRC9 (GNPI2_MOUSE)
Protein
Glucosamine-6-phosphate isomerase 2
Gene
Gnpda2
Organism
Mus musculus (Mouse)
Status
Functioni
Catalytic activityi
- EC:3.5.99.6
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 72 | Proton acceptor; for enolization stepBy similarity | 1 | |
Active sitei | 141 | For ring-opening stepBy similarity | 1 | |
Active sitei | 143 | Proton acceptor; for ring-opening stepBy similarity | 1 | |
Active sitei | 148 | For ring-opening stepBy similarity | 1 |
GO - Molecular functioni
- glucosamine-6-phosphate deaminase activity Source: MGI
- identical protein binding Source: GO_Central
GO - Biological processi
- carbohydrate metabolic process Source: UniProtKB-KW
- glucosamine catabolic process Source: GO_Central
- N-acetylglucosamine catabolic process Source: GO_Central
- N-acetylneuraminate catabolic process Source: GO_Central
- UDP-N-acetylglucosamine biosynthetic process Source: GO_Central
Keywordsi
Molecular function | Hydrolase |
Biological process | Carbohydrate metabolism |
Enzyme and pathway databases
Reactomei | R-MMU-70171, Glycolysis |
Names & Taxonomyi
Protein namesi | Recommended name: Glucosamine-6-phosphate isomerase 2 (EC:3.5.99.6)Alternative name(s): Glucosamine-6-phosphate deaminase 2 Short name: GNPDA 2 Short name: GlcN6P deaminase 2 |
Gene namesi | Name:Gnpda2 Synonyms:Kiaa4008 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1915230, Gnpda2 |
Subcellular locationi
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000343206 | 1 – 276 | Glucosamine-6-phosphate isomerase 2Add BLAST | 276 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 161 | PhosphothreonineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9CRC9 |
jPOSTi | Q9CRC9 |
PaxDbi | Q9CRC9 |
PeptideAtlasi | Q9CRC9 |
PRIDEi | Q9CRC9 |
2D gel databases
REPRODUCTION-2DPAGEi | Q3TH02 Q9CRC9 |
PTM databases
iPTMneti | Q9CRC9 |
PhosphoSitePlusi | Q9CRC9 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000029209, Expressed in spermatid and 284 other tissues |
Genevisiblei | Q9CRC9, MM |
Interactioni
Subunit structurei
Homohexamer.
By similarityGO - Molecular functioni
- identical protein binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000031117 |
Miscellaneous databases
RNActi | Q9CRC9, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 103 – 131 | Sequence analysisAdd BLAST | 29 |
Sequence similaritiesi
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG3148, Eukaryota |
GeneTreei | ENSGT00390000014316 |
HOGENOMi | CLU_049611_0_1_1 |
InParanoidi | Q9CRC9 |
OrthoDBi | 1425290at2759 |
TreeFami | TF300841 |
Family and domain databases
CDDi | cd01399, GlcN6P_deaminase, 1 hit |
HAMAPi | MF_01241, GlcN6P_deamin, 1 hit |
InterProi | View protein in InterPro IPR006148, Glc/Gal-6P_isomerase IPR004547, Glucosamine6P_isomerase IPR018321, Glucosamine6P_isomerase_CS IPR037171, NagB/RpiA_transferase-like |
PANTHERi | PTHR11280, PTHR11280, 1 hit |
Pfami | View protein in Pfam PF01182, Glucosamine_iso, 1 hit |
SUPFAMi | SSF100950, SSF100950, 1 hit |
TIGRFAMsi | TIGR00502, nagB, 1 hit |
PROSITEi | View protein in PROSITE PS01161, GLC_GALNAC_ISOMERASE, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9CRC9-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MRLVILDNYD LASEWAAKYI CNRIIKFKPG QDRYFSLGLP TGSTPLGCYK
60 70 80 90 100
KLIEYHKSGN LSFKYVKTFN MDEYVGLPRN HPESYHSYMW NNFFKHIDID
110 120 130 140 150
PNNAHILDGN AADLQAECDA FEEKIKEAGG IDLFVGGIGP DGHIAFNEPG
160 170 180 190 200
SSLVSRTRLK TLAMDTILAN AKYFDGDLSK VPTMALTVGV GTVMDAREVM
210 220 230 240 250
ILITGAHKAF ALYKAMEEGV NHMWTVSAFQ QHPRTIFVCD EDATLELRVK
260 270
TVKYFKGLMH VHNKLVDPLY SMKEGN
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD3YWR1 | D3YWR1_MOUSE | Glucosamine-6-phosphate isomerase | Gnpda2 | 270 | Annotation score: | ||
D6RCJ1 | D6RCJ1_MOUSE | Glucosamine-6-phosphate isomerase 2 | Gnpda2 | 48 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 101 | P → T in BAE40396 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_034581 | 137 – 138 | Missing in isoform 2. 1 Publication | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK015527 mRNA Translation: BAB29883.1 AK016785 mRNA Translation: BAB30428.1 AK017588 mRNA Translation: BAB30824.1 AK141408 mRNA Translation: BAE24675.1 AK166601 mRNA Translation: BAE38886.1 AK168516 mRNA Translation: BAE40396.1 AK171299 mRNA Translation: BAE42378.1 BC004084 mRNA Translation: AAH04084.1 |
CCDSi | CCDS19324.1 [Q9CRC9-1] CCDS84888.1 [Q9CRC9-2] |
RefSeqi | NP_001033104.1, NM_001038015.1 [Q9CRC9-1] NP_001334292.1, NM_001347363.1 [Q9CRC9-2] |
Genome annotation databases
Ensembli | ENSMUST00000031117; ENSMUSP00000031117; ENSMUSG00000029209 [Q9CRC9-1] ENSMUST00000139632; ENSMUSP00000121014; ENSMUSG00000029209 [Q9CRC9-1] ENSMUST00000166298; ENSMUSP00000128233; ENSMUSG00000029209 [Q9CRC9-2] ENSMUST00000173927; ENSMUSP00000133490; ENSMUSG00000029209 [Q9CRC9-2] |
GeneIDi | 67980 |
KEGGi | mmu:67980 |
UCSCi | uc008xqq.1, mouse [Q9CRC9-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK015527 mRNA Translation: BAB29883.1 AK016785 mRNA Translation: BAB30428.1 AK017588 mRNA Translation: BAB30824.1 AK141408 mRNA Translation: BAE24675.1 AK166601 mRNA Translation: BAE38886.1 AK168516 mRNA Translation: BAE40396.1 AK171299 mRNA Translation: BAE42378.1 BC004084 mRNA Translation: AAH04084.1 |
CCDSi | CCDS19324.1 [Q9CRC9-1] CCDS84888.1 [Q9CRC9-2] |
RefSeqi | NP_001033104.1, NM_001038015.1 [Q9CRC9-1] NP_001334292.1, NM_001347363.1 [Q9CRC9-2] |
3D structure databases
SMRi | Q9CRC9 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000031117 |
PTM databases
iPTMneti | Q9CRC9 |
PhosphoSitePlusi | Q9CRC9 |
2D gel databases
REPRODUCTION-2DPAGEi | Q3TH02 Q9CRC9 |
Proteomic databases
EPDi | Q9CRC9 |
jPOSTi | Q9CRC9 |
PaxDbi | Q9CRC9 |
PeptideAtlasi | Q9CRC9 |
PRIDEi | Q9CRC9 |
Protocols and materials databases
Antibodypediai | 23728, 121 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000031117; ENSMUSP00000031117; ENSMUSG00000029209 [Q9CRC9-1] ENSMUST00000139632; ENSMUSP00000121014; ENSMUSG00000029209 [Q9CRC9-1] ENSMUST00000166298; ENSMUSP00000128233; ENSMUSG00000029209 [Q9CRC9-2] ENSMUST00000173927; ENSMUSP00000133490; ENSMUSG00000029209 [Q9CRC9-2] |
GeneIDi | 67980 |
KEGGi | mmu:67980 |
UCSCi | uc008xqq.1, mouse [Q9CRC9-1] |
Organism-specific databases
CTDi | 132789 |
MGIi | MGI:1915230, Gnpda2 |
Rougei | Search... |
Phylogenomic databases
eggNOGi | KOG3148, Eukaryota |
GeneTreei | ENSGT00390000014316 |
HOGENOMi | CLU_049611_0_1_1 |
InParanoidi | Q9CRC9 |
OrthoDBi | 1425290at2759 |
TreeFami | TF300841 |
Enzyme and pathway databases
Reactomei | R-MMU-70171, Glycolysis |
Miscellaneous databases
BioGRID-ORCSi | 67980, 0 hits in 17 CRISPR screens |
ChiTaRSi | Gnpda2, mouse |
PROi | PR:Q9CRC9 |
RNActi | Q9CRC9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000029209, Expressed in spermatid and 284 other tissues |
Genevisiblei | Q9CRC9, MM |
Family and domain databases
CDDi | cd01399, GlcN6P_deaminase, 1 hit |
HAMAPi | MF_01241, GlcN6P_deamin, 1 hit |
InterProi | View protein in InterPro IPR006148, Glc/Gal-6P_isomerase IPR004547, Glucosamine6P_isomerase IPR018321, Glucosamine6P_isomerase_CS IPR037171, NagB/RpiA_transferase-like |
PANTHERi | PTHR11280, PTHR11280, 1 hit |
Pfami | View protein in Pfam PF01182, Glucosamine_iso, 1 hit |
SUPFAMi | SSF100950, SSF100950, 1 hit |
TIGRFAMsi | TIGR00502, nagB, 1 hit |
PROSITEi | View protein in PROSITE PS01161, GLC_GALNAC_ISOMERASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GNPI2_MOUSE | |
Accessioni | Q9CRC9Primary (citable) accession number: Q9CRC9 Secondary accession number(s): Q3TH02, Q9D457 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 2008 |
Last sequence update: | June 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 139 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families