UniProtKB - Q9CRB9 (MIC19_MOUSE)
MICOS complex subunit Mic19
Chchd3
Functioni
GO - Molecular functioni
- molecular adaptor activity Source: UniProtKB
- phosphatase binding Source: UniProtKB
GO - Biological processi
- cristae formation Source: MGI
- inner mitochondrial membrane organization Source: MGI
- mitochondrial fusion Source: MGI
Keywordsi
Molecular function | Repressor |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: MICOS complex subunit Mic19Alternative name(s): Coiled-coil-helix-coiled-coil-helix domain-containing protein 3 |
Gene namesi | Name:Chchd3 Synonyms:Mic19 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1913325, Chchd3 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Mitochondrion
- Mitochondrion inner membrane 1 Publication; Lipid-anchor 1 Publication; Intermembrane side 1 Publication
- Mitochondrion By similarity
Other locations
- Cytoplasm By similarity
Mitochondrion
- MICOS complex Source: MGI
- mitochondrial inner membrane Source: UniProtKB
- mitochondrion Source: UniProtKB
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, Membrane, Mitochondrion, Mitochondrion inner membrane, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 2 | G → A: Loss of SAMM50-binding. Reduced affinity toward OPA1. No effect on IMMT-binding. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000129164 | 2 – 227 | MICOS complex subunit Mic19Add BLAST | 226 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Lipidationi | 2 | N-myristoyl glycine1 Publication | 1 | |
Modified residuei | 29 | PhosphoserineCombined sources | 1 | |
Modified residuei | 49 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 50 | PhosphoserineCombined sources | 1 | |
Modified residuei | 51 | PhosphoserineCombined sources | 1 | |
Modified residuei | 56 | PhosphoserineCombined sources | 1 | |
Modified residuei | 58 | PhosphoserineBy similarity | 1 | |
Modified residuei | 142 | N6-acetyllysineBy similarity | 1 | |
Disulfide bondi | 183 ↔ 214 | PROSITE-ProRule annotation | ||
Disulfide bondi | 193 ↔ 204 | PROSITE-ProRule annotation |
Keywords - PTMi
Acetylation, Disulfide bond, Lipoprotein, Myristate, PhosphoproteinProteomic databases
EPDi | Q9CRB9 |
jPOSTi | Q9CRB9 |
MaxQBi | Q9CRB9 |
PaxDbi | Q9CRB9 |
PeptideAtlasi | Q9CRB9 |
PRIDEi | Q9CRB9 |
TopDownProteomicsi | Q9CRB9 |
PTM databases
iPTMneti | Q9CRB9 |
PhosphoSitePlusi | Q9CRB9 |
SwissPalmi | Q9CRB9 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000053768, Expressed in diaphragm and 317 other tissues |
ExpressionAtlasi | Q9CRB9, baseline and differential |
Genevisiblei | Q9CRB9, MM |
Interactioni
Subunit structurei
Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MICOS10/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and MICOS13/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2 (together described as components of the mitochondrial outer membrane sorting assembly machinery (SAM) complex) and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9. The MICOS and SAM complexes together with DNAJC11 are part of a large protein complex spanning both membranes termed the mitochondrial intermembrane space bridging (MIB) complex (By similarity).
Interacts with HSPA1A/HSPA1B and OPA1, preferentially with the soluble OPA1 form.
By similarity1 PublicationGO - Molecular functioni
- phosphatase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 211197, 31 interactors |
IntActi | Q9CRB9, 15 interactors |
MINTi | Q9CRB9 |
STRINGi | 10090.ENSMUSP00000070149 |
Miscellaneous databases
RNActi | Q9CRB9, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 180 – 222 | CHCHPROSITE-ProRule annotationAdd BLAST | 43 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 183 – 193 | Cx9C motif 1PROSITE-ProRule annotationAdd BLAST | 11 | |
Motifi | 204 – 214 | Cx9C motif 2PROSITE-ProRule annotationAdd BLAST | 11 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG4083, Eukaryota |
GeneTreei | ENSGT00390000000903 |
HOGENOMi | CLU_049040_2_1_1 |
InParanoidi | Q9CRB9 |
OMAi | ANQYMRC |
OrthoDBi | 1509756at2759 |
PhylomeDBi | Q9CRB9 |
TreeFami | TF326279 |
Family and domain databases
PROSITEi | View protein in PROSITE PS51808, CHCH, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MGGTASTRRV TFEADENENI TVVKGIRLSE NVIDRMKESS PSGSKSQRYS
60 70 80 90 100
SVYGASVSDE DLKRRVAEEL ALEQAKKESE HQRRLKQARD LERERAAANE
110 120 130 140 150
QLTRAVLRER ISSEEERMKA KHLARQLEEK DRVMRKQDAF YKEQLARLEE
160 170 180 190 200
RSSEFYKVTT EEYQKAAEEV EAKFKRYEYH PVCADLQTKI LQCYRQNTQQ
210 220
TLSCSALASQ YMHCVNHAKQ SMLEKGG
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9D9P1 | Q9D9P1_MOUSE | MICOS complex subunit Mic19 | Chchd3 | 175 | Annotation score: | ||
D3Z0L4 | D3Z0L4_MOUSE | MICOS complex subunit Mic19 | Chchd3 | 192 | Annotation score: | ||
S4R238 | S4R238_MOUSE | MICOS complex subunit Mic19 | Chchd3 | 84 | Annotation score: | ||
F6QFL0 | F6QFL0_MOUSE | MICOS complex subunit Mic19 | Chchd3 | 89 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK002263 mRNA Translation: BAB21974.1 AK003519 mRNA Translation: BAB22832.1 BC021941 mRNA Translation: AAH21941.1 |
CCDSi | CCDS19986.1 |
RefSeqi | NP_079612.1, NM_025336.1 |
Genome annotation databases
Ensembli | ENSMUST00000066379; ENSMUSP00000070149; ENSMUSG00000053768 |
GeneIDi | 66075 |
KEGGi | mmu:66075 |
UCSCi | uc009bgo.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK002263 mRNA Translation: BAB21974.1 AK003519 mRNA Translation: BAB22832.1 BC021941 mRNA Translation: AAH21941.1 |
CCDSi | CCDS19986.1 |
RefSeqi | NP_079612.1, NM_025336.1 |
3D structure databases
SMRi | Q9CRB9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 211197, 31 interactors |
IntActi | Q9CRB9, 15 interactors |
MINTi | Q9CRB9 |
STRINGi | 10090.ENSMUSP00000070149 |
PTM databases
iPTMneti | Q9CRB9 |
PhosphoSitePlusi | Q9CRB9 |
SwissPalmi | Q9CRB9 |
Proteomic databases
EPDi | Q9CRB9 |
jPOSTi | Q9CRB9 |
MaxQBi | Q9CRB9 |
PaxDbi | Q9CRB9 |
PeptideAtlasi | Q9CRB9 |
PRIDEi | Q9CRB9 |
TopDownProteomicsi | Q9CRB9 |
Protocols and materials databases
Antibodypediai | 32162, 285 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000066379; ENSMUSP00000070149; ENSMUSG00000053768 |
GeneIDi | 66075 |
KEGGi | mmu:66075 |
UCSCi | uc009bgo.1, mouse |
Organism-specific databases
CTDi | 54927 |
MGIi | MGI:1913325, Chchd3 |
Phylogenomic databases
eggNOGi | KOG4083, Eukaryota |
GeneTreei | ENSGT00390000000903 |
HOGENOMi | CLU_049040_2_1_1 |
InParanoidi | Q9CRB9 |
OMAi | ANQYMRC |
OrthoDBi | 1509756at2759 |
PhylomeDBi | Q9CRB9 |
TreeFami | TF326279 |
Miscellaneous databases
BioGRID-ORCSi | 66075, 1 hit in 17 CRISPR screens |
ChiTaRSi | Chchd3, mouse |
PROi | PR:Q9CRB9 |
RNActi | Q9CRB9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000053768, Expressed in diaphragm and 317 other tissues |
ExpressionAtlasi | Q9CRB9, baseline and differential |
Genevisiblei | Q9CRB9, MM |
Family and domain databases
PROSITEi | View protein in PROSITE PS51808, CHCH, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MIC19_MOUSE | |
Accessioni | Q9CRB9Primary (citable) accession number: Q9CRB9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 12, 2005 |
Last sequence update: | June 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 132 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families